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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Contrast-enhanced mammogram Clear all
Completed Not applicable Interventional

Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings

NCT03929783
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Contrast Enhanced Digital Mammography
Procedure
Lead sponsor
Thomas Jefferson University
Other
Eligibility
30 Years to 80 Years · Female only
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 10, 2026, 3:22 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Abbreviated Breast MRI and Digital Tomosynthesis Mammography in Screening Women With Dense Breasts

NCT02933489
View directory record Official record
Conditions
Asymptomatic
Interventions
Contrast-enhanced Magnetic Resonance Imaging, Digital Tomosynthesis Mammography, Quality-of-Life Assessment, Questionnaire Administration
Diagnostic Test · Other
Lead sponsor
ECOG-ACRIN Cancer Research Group
Network
Eligibility
40 Years to 75 Years · Female only
Enrollment
1,516 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
67
States / cities
Gilbert, Arizona • Pasadena, California • Denver, Colorado + 54 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Active, not recruiting No phase listed Observational

MRI Background Parenchymal Enhancement as a Risk Factor for Breast Cancer: The IMAGINg and Epidemiology (IMAGINE) Study

NCT02301767
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years to 69 Years · Female only
Enrollment
2,187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2026
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Commack, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Not listed No phase listed Observational

Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis

NCT05369546
View directory record Official record
Conditions
Breast Cancer
Interventions
q3CB
Diagnostic Test
Lead sponsor
University of Hawaii
Other
Eligibility
20 Years to 85 Years · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Tampa, Florida • Hilo, Hawaii • Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional

Comparison of MRI and CEDM to Evaluate Treatment Response Before Surgery

NCT03070340
View directory record Official record
Conditions
Breast Cancer
Interventions
Breast Magnetic Resonance Imaging (MRI), Contrast Enhanced Mammography (CEDM)
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
Female only
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
5
States / cities
Basking Ridge, New Jersey • Montvale, New Jersey • Commack, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Screening Contrast-Enhanced Mammography as an Alternative to MRI

NCT04764292
View directory record Official record
Conditions
Breast Cancer
Interventions
Contrast-enhanced mammography, Iodinated Contrast Media (ICM)
Device · Drug
Lead sponsor
Wendie Berg
Other
Eligibility
30 Years to 75 Years · Female only
Enrollment
615 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
3
States / cities
Cranberry Township, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional Results available

Contrast Enhanced Spectral Mammography vs. MRI for Breast Cancer Screening

NCT03482557
View directory record Official record
Conditions
Breast Cancer
Interventions
CESM, MRI
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
30 Years to 110 Years · Female only
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Sep 10, 2026, 3:22 AM EDT
Completed No phase listed Observational

Diagnostic Procedures in Women With Locally Advanced Breast Cancer Who Are Receiving Chemotherapy Before Breast Cancer Surgery

NCT00033397
View directory record Official record
Conditions
Breast Cancer
Interventions
biopsy, magnetic resonance imaging, radiomammography, ultrasound imaging, gadopentetate dimeglumine, chemotherapy
Procedure · Radiation · Drug
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2012
U.S. locations
5
States / cities
San Francisco, California • Chicago, Illinois • Minneapolis, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2017 · Synced Sep 10, 2026, 3:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

NCT05625659
View directory record Official record
Conditions
Breast Cancer
Interventions
Dual-Energy Contrast-Enhanced Spectral Mammography (CESM)
Diagnostic Test
Lead sponsor
American College of Radiology
Other
Eligibility
45 Years to 74 Years · Female only
Enrollment
2,032 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
12
States / cities
Birmingham, Alabama • Boca Raton, Florida • The Villages, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Terminated No phase listed Observational

Can Contrast-Enhanced Spectral Mammography Improve the Accuracy of a Diagnosis

NCT03929822
View directory record Official record
Conditions
Breast Screening
Interventions
Contrast-Enhanced Spectral Mammography
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
30 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 10, 2026, 3:22 AM EDT
Recruiting Early Phase 1 Interventional

Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer

NCT06220214
View directory record Official record
Conditions
Breast Cancer, Locally Advanced Breast Cancer, Neoadjuvant Chemotherapy, HER2-positive Breast Cancer, Triple Negative Breast Cancer, TNBC, Triple Negative Breast Cancer
Interventions
CEDM, CEDBT, Omnipaque 350mgI/mL Solution for Injection
Diagnostic Test · Drug
Lead sponsor
Alison Stopeck
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Terminated Phase 4 Interventional Results available

Performance of Contrast-Enhanced Spectral Mammography to Assess Neoadjuvant Chemotherapy Response (CEDM)

NCT04625517
View directory record Official record
Conditions
Breast Cancer
Interventions
Digital Mammography, Low Osmolar Contrast Material, 300-399 Mg/Ml Iodine Concentration, Per Ml
Procedure · Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Sep 10, 2026, 3:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Diagnostic Utility of MRI in Female Patients With Nipple Discharge: A Prospective Trial

NCT02818946
View directory record Official record
Conditions
Disorder of Nipple, Breast Neoplasms
Interventions
MRI
Device
Lead sponsor
Duke University
Other
Eligibility
22 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Sep 10, 2026, 3:22 AM EDT
Active, not recruiting Not applicable Interventional

Prospective Case Collection Study of Contrast-Enhanced Mammography Imaging Acquired on a New Investigational Device

NCT06636539
View directory record Official record
Conditions
Breast Screening
Interventions
CEM Software in New Mammography Device
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
35 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Houston, Texas • Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Screening CEDM in Intermediate and High-Risk Patient Populations

NCT03859492
View directory record Official record
Conditions
Breast Cancer
Interventions
Contrast Enhanced Digital Mammography
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
35 Years and older · Female only
Enrollment
461 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 10, 2026, 3:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening

NCT04904757
View directory record Official record
Conditions
Mammographic Breast Density, Mammography
Interventions
Contrast-enhanced spectral mammography (CESM)
Device
Lead sponsor
University of Virginia
Other
Eligibility
40 Years to 69 Years · Female only
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Sep 10, 2026, 3:22 AM EDT
Completed No phase listed Observational

Comparison of Whole Breast Screening Ultrasound and Contrast Enhanced Mammography for Supplemental Breast Cancer Screening

NCT02310698
View directory record Official record
Conditions
Breast Cancer Screening
Interventions
contrast enhanced digital mammography (CEDM), whole breast screening ultrasound (WBUS)
Device
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
30 Years and older · Female only
Enrollment
487 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 10, 2026, 3:22 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study

NCT05206331
View directory record Official record
Conditions
Breast Cancer
Interventions
contrast enhanced mammography, Iodinated Contrast Media (ICM)
Device · Drug
Lead sponsor
Margarita Louise Zuley
Other
Eligibility
30 Years and older · Female only
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional Results available

Contrast-Enhanced Mammography for Breast Cancer Staging in Patients Referred for a Second Opinion

NCT05036083
View directory record Official record
Conditions
Breast Carcinoma, Invasive Breast Carcinoma
Interventions
Contrast-Enhanced Mammography, Digital Tomosynthesis Mammography, Electronic Health Record Review, Iodinated Contrast Agent
Procedure · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Phase 4 Interventional

Dotarem vs Gadobutrol Contrast for Breast MRI

NCT03730051
View directory record Official record
Conditions
Breast Diseases
Interventions
Gadoterate meglumine, Gadobutrol
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 10, 2026, 3:22 AM EDT
Completed No phase listed Observational

Dual-energy Contrast-enhanced (2D and 3D Mammography Versus Contrast-enhanced MRI)- A Pilot Study

NCT01433640
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Hologic, Inc.
Industry
Eligibility
25 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Early Phase 1 Interventional

Comparison of Three Methods for Early Detection of Breast Cancer

NCT03954015
View directory record Official record
Conditions
Proliferative Breast Disease
Interventions
Contrast Enhanced imaging, Lumason
Diagnostic Test · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2022 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography

NCT02995980
View directory record Official record
Conditions
Breast Cancer
Interventions
Dual-Energy Contrast-Enhanced (DECE) mammography, digital mammography
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Sep 10, 2026, 3:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Prospective, Multi-site Clinical Study to Collect User Feedback Using Affirm® Contrast Biopsy

NCT04671329
View directory record Official record
Conditions
Breast Cancer
Interventions
Affirm Contrast Biopsy procedure
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
40 Years and older · Female only
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Phoenix, Arizona • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 10, 2026, 3:22 AM EDT