- Conditions
- Keratoconus
- Interventions
- Laser Custom Corneal Collagen Cross-Linking
- Procedure
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2027
- U.S. locations
- 1
- States / cities
- Portland, Oregon
Search Results
Search by objective public record fields.
Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Showing 1–24
of 56
matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Interventions
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Combination Product
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 2,228 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2020
- U.S. locations
- 9
- States / cities
- Scottsdale, Arizona • San Francisco, California • Littleton, Colorado + 6 more
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Interventions
- Epi-ON corneal cross-linking (CXL)
- Combination Product
- Lead sponsor
- Woolfson Eye Institute
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 225 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 12
- States / cities
- Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more
- Conditions
- Hyperopia, Hyperopic Astigmatism
- Interventions
- riboflavin ophthalmic solution, 0% dextran, UVA Irradiation (30 mW/cm2 for 2 minutes continuous UVA), UVA Irradiation (30 mW/cm2 for 3 minutes pulsed UVA with an on/off cycle of 2 seconds UVA on/1 second UVA off), Laser-assisted in situ keratomileusis
- Drug · Device · Procedure
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 2 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2016
- U.S. locations
- 5
- States / cities
- San Diego, California • Waltham, Massachusetts • Teaneck, New Jersey + 2 more
- Conditions
- Corneal Transplant Failure
- Interventions
- Corneal Donor Tissue with Cross Linking, Corneal Donor Tissue without Cross Linking
- Procedure
- Lead sponsor
- Massachusetts Eye and Ear Infirmary
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 96 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2031
- U.S. locations
- 12
- States / cities
- Irvine, California • Los Angeles, California • San Francisco, California + 9 more
- Conditions
- Keratoconus
- Interventions
- Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment
- Combination Product
- Lead sponsor
- Epion Therapeutics
- Industry
- Eligibility
- 8 Years to 45 Years
- Enrollment
- 398 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 12
- States / cities
- Scottsdale, Arizona • Tucson, Arizona • Murrieta, California + 9 more
- Conditions
- Keratoconus
- Interventions
- Riboflavin-5-phosphate, Sham cross-linking
- Drug
- Lead sponsor
- University at Buffalo
- Other
- Eligibility
- 16 Years to 35 Years
- Enrollment
- 150 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2008 – 2011
- U.S. locations
- 2
- States / cities
- Amherst, New York • Buffalo, New York
- Conditions
- Corneal Thinning, Keratoconus
- Interventions
- Pulsed or continuous lighting
- Combination Product
- Lead sponsor
- Vishal Jhanji
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2031
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Cornea Associates of Texas
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer, Fungal Ulcer
- Interventions
- Corneal Cross-linking, Anti Fungal Drug
- Procedure · Drug
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 147 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Keratoconus
- Interventions
- riboflavin solution, placebo solution, KXL System
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 230 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2016
- U.S. locations
- 8
- States / cities
- San Diego, California • Indianapolis, Indiana • Overland Park, Kansas + 5 more
- Conditions
- Keratoconus
- Interventions
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Drug
- Lead sponsor
- Maanasa Indaram, MD
- Other
- Eligibility
- 13 Years to 64 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 3
- States / cities
- San Francisco, California
- Conditions
- Progressive Keratoconus, Corneal Ectasia
- Interventions
- Corneal collagen, Sham comparator
- Procedure
- Lead sponsor
- Emory University
- Other
- Eligibility
- 14 Years and older
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2010
- U.S. locations
- 1
- States / cities
- Atlanta, Georgia
- Conditions
- Progressive Keratoconus
- Interventions
- NXL Energy 1, NXL Energy 2, NXL Energy 3, Sham Treatment
- Combination Product
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 150 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2026
- U.S. locations
- 3
- States / cities
- Dothan, Alabama • Teaneck, New Jersey • Westerville, Ohio
- Conditions
- Keratoconus, Post-Refractive Ectasia
- Interventions
- Riboflavin, UVX light
- Drug · Device
- Lead sponsor
- Price Vision Group
- Industry
- Eligibility
- 10 Years and older
- Enrollment
- 510 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2017
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
- Conditions
- Corneal Ectasia Disorders Including Keratoconus
- Interventions
- CXL
- Drug
- Lead sponsor
- Rush Eye Associates
- Other
- Eligibility
- 10 Years to 70 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2024
- U.S. locations
- 1
- States / cities
- Amarillo, Texas
- Conditions
- Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
- Interventions
- PXL 330 Platinum device/Riboflavin
- Combination Product
- Lead sponsor
- Eye Specialists of Indiana
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
- Conditions
- Ectasia
- Interventions
- riboflavin ophthalmic solution, UVA Irradiation
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 14 Years and older
- Enrollment
- 130 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2011
- U.S. locations
- 10
- States / cities
- La Jolla, California • San Diego, California • Miami, Florida + 7 more
- Conditions
- Fruste Keratoconus, Risk of Ectasia
- Interventions
- Corneal Cross-Linking, Riboflavin
- Device · Drug
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 22 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2014
- U.S. locations
- 8
- States / cities
- Scottsdale, Arizona • San Diego, California • Miami, Florida + 5 more
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- KXL System (15 mW/cm2), KXL System (30 mW/cm2), KXL System (45 mW/cm2), riboflavin ophthalmic solution
- Device · Drug
- Lead sponsor
- American-European Congress of Ophthalmic Surgery
- Network
- Eligibility
- 12 Years and older
- Enrollment
- 1,721 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2016
- U.S. locations
- 82
- States / cities
- Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 71 more
- Conditions
- Keratoconus, Ectasia, Degeneration
- Interventions
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Drug
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 3,493 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2017
- U.S. locations
- 16
- States / cities
- Scottsdale, Arizona • Laguna Hills, California • San Diego, California + 13 more
- Conditions
- Unstable Corneas
- Interventions
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam, UV Pulsed Beam
- Drug · Device
- Lead sponsor
- Crowd Health Research, LTD
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Started 2014
- U.S. locations
- 16
- States / cities
- Santa Rosa, California • Denver, Colorado • Jacksonville, Florida + 13 more
- Conditions
- Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Colorado Eye Consultants/Cornea Consultants of Colorado
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2023
- U.S. locations
- 3
- States / cities
- Littleton, Colorado • Highland Park, Illinois • Brecksville, Ohio
- Conditions
- Keratoconus
- Interventions
- CATS Tonometer
- Device
- Lead sponsor
- Intuor Technologies, Inc.
- Industry
- Eligibility
- 18 Years to 101 Years
- Enrollment
- 18 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019
- U.S. locations
- 1
- States / cities
- Tucson, Arizona