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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:23 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–117 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Creatine Supplementation Clear all

Conditions: Local Anesthetic Complication, Local Anesthetic Drug Adverse Reaction
Interventions: Not listed
Lead sponsor: Benaroya Research Institute; Other
Eligibility: Not listed
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Constipation
Interventions: MOVANTIK™ (naloxegol), Sugar Pill; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Dual Diagnosis, Substance Use
Interventions: Creatine monohydrate; Drug
Lead sponsor: Perry Renshaw; Other
Eligibility: 13 Years to 55 Years · Female only
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Fatigue
Interventions: Creatine Monohydrate, Control; Dietary Supplement
Lead sponsor: Ward Dobbs; Other
Eligibility: 18 Years to 55 Years · Male only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: La Crosse, Wisconsin

Conditions: Major Depressive Disorder
Interventions: 5-Hydroxytryptophan 100 MG, Creatine monohydrate, placebo matched to 5-HTP, Placebo; Drug
Lead sponsor: University of Utah; Other
Eligibility: 25 Years to 40 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Mitochondrial Disease
Interventions: Not listed
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Muscular Dystrophy, Duchenne
Interventions: glutamine, creatine monohydrate; Drug
Lead sponsor: National Center for Research Resources (NCRR); NIH
Eligibility: 5 Years to 10 Years · Male only
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Presbyphonia
Interventions: Creatine monohydrate, Placebo; Dietary Supplement
Lead sponsor: NYU Langone Health; Other
Eligibility: 65 Years to 100 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss, Older Adults
Interventions: Calcium-HMB Plus Vitamin D3, Matching placebo; Dietary Supplement · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 65 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Exercise Performance
Interventions: Placebo, Creatine; Dietary Supplement
Lead sponsor: California Polytechnic State University-San Luis Obispo; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Luis Obispo, California

Conditions: Hypercholesterolemia, Aches, Cramps, Weakness
Interventions: Creatine; Dietary Supplement
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006
U.S. locations: 1
States / cities: Wooster, Ohio

Conditions: Alzheimer's Disease
Interventions: Creatine Monohydrate; Dietary Supplement
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 60 Years to 90 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Amyotrophic Lateral Sclerosis
Interventions: Creatinine; Drug
Lead sponsor: National Center for Research Resources (NCRR); NIH
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Exercise Induced Muscle Damage, Cryotherapy
Interventions: Cryotherapy, Eccentric exercise-induced muscle damage; Other
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 18 Years to 30 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Amyotrophic Lateral Sclerosis
Interventions: creatine monohydrate; Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: 21 Years to 80 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 6
States / cities: San Francisco, California • Chicago, Illinois • Kansas City, Kansas + 3 more

Conditions: Major Depressive Disorder
Interventions: Creatine Monohydrate; Drug
Lead sponsor: University of Utah; Other
Eligibility: 13 Years to 18 Years · Female only
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Major Depressive Disorder
Interventions: Creatine monohydrate, Placebo; Dietary Supplement · Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 99 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Amyotrophic Lateral Sclerosis
Interventions: creatine, tamoxifen; Drug
Lead sponsor: Nazem Atassi; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 9
States / cities: Kansas City, Kansas • Boston, Massachusetts • Worcester, Massachusetts + 6 more

Conditions: Supplement
Interventions: T+ Supplement, Placebo; Other
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 35 Years · Male only
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Parkinson's Disease
Interventions: creatine, placebo; Drug · Other
Lead sponsor: University of Rochester; Other
Eligibility: Not listed
Enrollment: 1,741 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2014
U.S. locations: 48
States / cities: Birmingham, Alabama • Phoenix, Arizona • Fountain Valley, California + 40 more

Conditions: ALS (Amyotrophic Lateral Sclerosis)
Interventions: Lunasin Regimen, Historical control; Drug · Other
Lead sponsor: Richard Bedlack, M.D., Ph.D.; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

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Defining Normal Postoperative Magnetic Resonance Imaging After Total Knee Arthroplasty

Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients

Open-Label Creatine Study for Female Meth Users

The Effects of Nutritional Supplementation on Occupational Performance in Firefighters

5-HTP and Creatine for Depression

Magnetic Resonance Imaging (MRI) Muscle Phenotyping in Mitochondrial Disease

A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD)

Creatine Supplementation for Improved Voice Performance in the Elderly

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

Creatine Supplementation At Simulated Altitude

Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs

Creatine to Augment Bioenergetics in Alzheimer's

Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis

Acute Cryotherapy on Musculoskeletal Function and Biomarkers

Creatine for the Treatment of Amyotrophic Lateral Sclerosis

Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram

A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive Disorder

Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Multi-ingredient Supplement for Strength and Power

NET-PD LS-1 Creatine in Parkinson's Disease

ALS Reversals - Lunasin Regimen