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ClinicalTrials.gov public records Last synced Sep 8, 2026, 4:34 PM EDT

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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: CryoBalloon Clear all
Withdrawn Not applicable Interventional

Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation

NCT02344394
View directory record Official record
Conditions
Persistent Atrial Fibrillation
Interventions
Medtronic Cryoballoon, Thermocool Catheter, nContact
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

One More Magnetic Resonance Imaging

NCT02293070
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Delayed Enhanced Cardiac Magnetic Resonance Imaging, Cryoablation
Other · Procedure
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Sep 8, 2026, 4:34 PM EDT
Withdrawn No phase listed Observational

PVI Using Cryoablation Alone in Paroxysmal AF Patients Converted From Persistent AF With Dofetilide

NCT01877486
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions
Ablation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Ridgewood, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 3, 2016 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium

NCT02534233
View directory record Official record
Conditions
Barrett's Esophagus, Esophageal Squamous Dysplasia, Esophageal Cancer
Interventions
CryoBalloon
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 8, 2026, 4:34 PM EDT
Active, not recruiting Phase 4 Interventional

Liraglutide Effect in Atrial Fibrillation

NCT03856632
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Liraglutide, RFM, Anti Arrhythmics, Afib Catheter Ablation
Drug · Other · Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium

NCT01293448
View directory record Official record
Conditions
Barrett's Esophagus, Esophageal Cancer
Interventions
Cryoballoon Ablation
Device
Lead sponsor
Pentax Medical
Industry
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Los Angeles, California • Rochester, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

aMAZE Trial Continued Access Protocol

NCT04468334
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
LARIAT + PVI
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
25
States / cities
San Francisco, California • Stanford, California • Jacksonville, Florida + 22 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Sep 8, 2026, 4:34 PM EDT
Terminated No phase listed Observational

All Inclusive Kodex - EPD Study

NCT05489445
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
KODEX - EPD
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 8, 2026, 4:34 PM EDT
Completed No phase listed Observational

Evaluating the Performance of the KODEX-EPD CRyOballoon Occlusion Feature in Patients With Atrial Fibrillation

NCT04293198
View directory record Official record
Conditions
Atrium; Fibrillation, Ablation
Interventions
KODEX-EPD System, Fluoroscopy with contrast dye
Device
Lead sponsor
EPD Solutions, A Philips Company
Industry
Eligibility
18 Years to 120 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

Cryo Balloon for Residual Barrett's Esophagus

NCT02230410
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
CryoBalloon Focal Ablation
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 9, 2022 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

CryoBalloon Ablation for Treatment of Duodenal Adenomas

NCT03847636
View directory record Official record
Conditions
Duodenal Adenomas, Familial Adenomatous Polyposis
Interventions
CryoBalloon ablation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
4
States / cities
Baltimore, Maryland • Manhasset, New York • Danville, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 8, 2026, 4:34 PM EDT
Completed No phase listed Observational

FREEZE Cohort Study

NCT01360008
View directory record Official record
Conditions
Arrhythmia
Interventions
Not listed
Lead sponsor
Stiftung Institut fuer Herzinfarktforschung
Other
Eligibility
18 Years and older
Enrollment
4,071 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Asheville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2019 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

Reduction of Radiation Dose and Contrast Use During Cryoballoon Pulmonary Vein Isolation

NCT03786822
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Cryoballoon Pulmonary Vein Isolation - PVI
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 25, 2018 · Synced Sep 8, 2026, 4:34 PM EDT
Active, not recruiting Not applicable Interventional

Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)

NCT03554356
View directory record Official record
Conditions
Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
Interventions
CryoBalloon Focal Ablation System
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
11
States / cities
Birmingham, Alabama • Washington D.C., District of Columbia • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

Cryoballoon vs. Rhythmia Guided Ablation for Recurrent AFib

NCT03811795
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
ECG monitoring with a Kardia Mobile monitor
Other
Lead sponsor
Valley Health System
Other
Eligibility
18 Years to 100 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
West Des Moines, Iowa • Paramus, New Jersey • Springfield, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

NCT04133168
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Boston Scientific Cardiac Cryoablation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Jonesboro, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

NCT03118518
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Fibrillation New Onset
Interventions
Cryoablation, Antiarrhythmic drug
Device · Drug
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years to 80 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
24
States / cities
Birmingham, Alabama • Anchorage, Alaska • Newport Beach, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

Atrial Fibrillation Recurrence After Cryoballoon Ablation

NCT01772030
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Use of the Achieve catheter followed by ICE-guided mapping catheter
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Sep 8, 2026, 4:34 PM EDT
Terminated No phase listed Observational

Release of Acetylcholine From the Ganglionated Plexus During the Thaw Phase of Cryoballon Pulmonary Vein Ablation (GP RESPONSE Study)

NCT03636100
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Cryoballoon ablation
Device
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Timeline
2018 – 2019
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 18, 2021 · Synced Sep 8, 2026, 4:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF

NCT05296824
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Cryoballoon ablation for the treatment of atrial fibrillation
Procedure
Lead sponsor
Sacramento EP Research
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
4
States / cities
Sacramento, California • Loveland, Colorado • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional

The OneFreeze Study

NCT02217254
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Atrial fibrillation catheter ablation using the Medtronic Arctic Front Ablation System
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
San Francisco, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Phase 3 Interventional

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

NCT01873352
View directory record Official record
Conditions
Atrial Fibrillation, Hypertension
Interventions
catheter ablation, renal sympathetic denervation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Short Hills, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Phase 3 Interventional

Cryoballoon Ablation of Pulmonary Veins After Failed RF Ablation in Patients With Paroxysmal AF

NCT01611701
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
cryoballoon ablation, Radiofrequency ablation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2012 · Synced Sep 8, 2026, 4:34 PM EDT
Completed Not applicable Interventional Results available

Clinical Study to Evaluate CryoBalloon™ Full and Swipe Ablation Systems for Ablation of Human Esophageal Epithelium

NCT02729753
View directory record Official record
Conditions
Esophageal Cancer
Interventions
CryoBalloon™ Full Ablation System, CryoBalloon™ Swipe Ablation System
Device
Lead sponsor
Pentax Medical
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
Houston, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Sep 8, 2026, 4:34 PM EDT