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Showing 1–24 of 191 matching trials from the live ClinicalTrials.gov search.
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Recruiting Phase 4 Interventional

Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft

NCT06379724
View directory record Official record
Conditions
Burns, Skin Graft Complications
Interventions
Tranexamic acid, Thrombin JMI, skin graft
Drug · Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 25, 2026, 5:00 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

NCT06820177
View directory record Official record
Conditions
Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use, Blood Loss
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
San Diego, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Oral Versus Intravenous Tranexamic Acid

NCT04089865
View directory record Official record
Conditions
Blood Loss, Blood Transfusion
Interventions
Tranexamic Acid
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 25, 2026, 5:00 PM EDT
Recruiting Phase 3 Interventional

Tranexamic Acid in Adult Spinal Deformity Surgery

NCT03553186
View directory record Official record
Conditions
Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
Interventions
Tranexamic Acid 100 MG/ML, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 1 Interventional

A Study to Evaluate the Safety, Tolerability and Efficacy of LB1148 for Subjects Undergoing Elective Bowel Resection

NCT04100447
View directory record Official record
Conditions
Adhesions, Ileus
Interventions
Tranexamic Acid
Drug
Lead sponsor
Ronald Hurst, MD, FACS
Other
Eligibility
18 Years to 85 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Inglewood, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Not applicable Interventional Results available

Oral vs. Intravenous TXA Study Proposal: TJA

NCT02233101
View directory record Official record
Conditions
Blood Loss After Primary Total Joint Arthroplasty, Need for Blood Transfusion After Total Joint Arthroplasty
Interventions
Oral Tranexamic Acid, Intravenous Tranexamic Acid
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 27, 2017 · Synced Sep 25, 2026, 5:00 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Oral Tranexamic Acid and Laser for Treatment of Melasma

NCT03686787
View directory record Official record
Conditions
Melasma
Interventions
Tranexamic Acid
Drug
Lead sponsor
Laser and Skin Surgery Center of New York
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 26, 2018 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation

NCT04651166
View directory record Official record
Conditions
Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
Interventions
Tranexamic acid, Placebo
Drug
Lead sponsor
University of Hawaii
Other
Eligibility
14 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 4 Interventional Results available

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

NCT03317795
View directory record Official record
Conditions
Heavy Menstrual Bleeding, Menorrhagia, Uterine Fibroids
Interventions
Levonorgestrel IUS, Tranexamic Acid
Drug
Lead sponsor
Shannon K. Laughlin-Tommaso
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Sep 25, 2026, 5:00 PM EDT
Recruiting Phase 4 Interventional

The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery

NCT06450392
View directory record Official record
Conditions
Orbital Edema, Orbital Ecchymosis
Interventions
Tranexamic acid injection, Tranexamic Acid in NaCl,Iso-Os 1,000 Mg/100 mL (10 Mg/mL) INTRAVEN INTRAVENOUS SOLUTION, PIGGYBACK (ML), normal saline - injection, normal saline - intravenous
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 25, 2026, 5:00 PM EDT
Terminated Phase 2 Interventional

Single Dose Enteral Tranexamic Acid in Critically Ill Patients

NCT01683747
View directory record Official record
Conditions
Shock, Sepsis, Hypotension, Critical Illness
Interventions
Tranexamic Acid, Control Intervention (Carrier fluid only)
Drug
Lead sponsor
San Diego Veterans Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery

NCT02684851
View directory record Official record
Conditions
Acetabular Fractures
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Columbia, Missouri • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Sep 25, 2026, 5:00 PM EDT
Terminated Early Phase 1 Interventional

Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery

NCT04630886
View directory record Official record
Conditions
Skin Neoplasms
Interventions
Tranexamic acid injection, Lidocaine Epinephrine
Drug
Lead sponsor
Riley McLean
Other
Eligibility
18 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Sep 25, 2026, 5:00 PM EDT
Withdrawn Phase 4 Interventional

Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint Arthroplasty

NCT02926651
View directory record Official record
Conditions
Anemia, Arthritis, Total Knee Arthroplasty, Total Hip Arthroplasty
Interventions
Conventional Oral TXA (Tranexamic Acid), Multi-Dose Oral TXA (Tranexamic Acid)
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 4 Interventional Results available

Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery

NCT04754230
View directory record Official record
Conditions
Chronic Sinusitis, Nasal Obstruction, Turbinate; Hypertrophy Mucous Membrane, Deviated Nasal Septum - Congenital, Deviated Nasal Septum Acquired
Interventions
Tranexamic Acid 1,000 Mg/10 mL (100 Mg/mL) INTRAVEN VIAL (ML)
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Sep 25, 2026, 5:00 PM EDT
Completed No phase listed Observational

Evaluation of Tranexamic Acid for Angiotensin-converting Enzyme Inhibitor-induced Angioedema in the Emergency Department

NCT06096077
View directory record Official record
Conditions
Angioedema
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 4 Interventional Results available

Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding

NCT01190150
View directory record Official record
Conditions
Menorrhagia
Interventions
tranexamic acid
Drug
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
12 Years to 16 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2012 · Synced Sep 25, 2026, 5:00 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty

NCT03359525
View directory record Official record
Conditions
Tranexamic Acid Adverse Reaction
Interventions
Tranexamic Acid
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 80 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Dec 1, 2017 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Early Phase 1 Interventional

IV Tranexamic Acid Prior to Hysterectomy

NCT02911831
View directory record Official record
Conditions
Hysterectomy, Blood Loss, Surgical
Interventions
Tranexamic Acid, Sodium Chloride
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population

NCT03923959
View directory record Official record
Conditions
Hip Fractures
Interventions
Tranexamic Acid Injectable Solution, Placebo
Drug · Other
Lead sponsor
Lancaster General Hospital
Other
Eligibility
65 Years and older
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Sep 25, 2026, 5:00 PM EDT
Completed Not applicable Interventional Results available

Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid

NCT02051686
View directory record Official record
Conditions
Acetabulum Fractures
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Sep 25, 2026, 5:00 PM EDT
Terminated Phase 2 Interventional Results available

Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148

NCT02317549
View directory record Official record
Conditions
Septic Shock
Interventions
LB1148, Placebo
Drug
Lead sponsor
Leading BioSciences, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
26
States / cities
Mobile, Alabama • Fresno, California • Long Beach, California + 23 more
Source: ClinicalTrials.gov public record
Updated May 31, 2020 · Synced Sep 25, 2026, 5:00 PM EDT
Withdrawn Phase 2 Interventional

Efficacy of Tranexamic Acid (TXA) in Humerus ORIF

NCT05802238
View directory record Official record
Conditions
Fracture Humerus
Interventions
Tranexamic acid (TXA), Saline
Drug · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 25, 2026, 5:00 PM EDT
Withdrawn No phase listed Observational

The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates

NCT01914211
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Tranexamic Acid, Acute Normovolemic Hemodilution
Drug · Procedure
Lead sponsor
Aymen N Naguib
Other
Eligibility
Up to 28 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Sep 25, 2026, 5:00 PM EDT