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ClinicalTrials.gov public records Last synced Nov 5, 2026, 11:33 AM EST

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Showing 25–48 of 51 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Deep Brain Stimulator Clear all

Conditions: Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
Interventions: SCC DBS; Device
Lead sponsor: Paul Holtzheimer; Other
Eligibility: 22 Years to 70 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Essential Tremor, Parkinson Disease, Dystonia
Interventions: Active biphasic pulse stimulation---Home Settings, Active biphasic pulse stimulation---VIN Biphasic, Active biphasic pulse stimulation---Stimulator Off; Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Gainesville, Florida

Conditions: Essential Tremor
Interventions: Deep brain stimulation, Closed-loop deep brain stimulation; Device
Lead sponsor: University of Florida; Other
Eligibility: 21 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Sarcopenia
Interventions: Not listed
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 40 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
Interventions: SCC DBS; Device
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Epilepsy; Seizure
Interventions: Phase 1-Validation of thalamus seizure detection with concurrent video EEG monitoring, Phase 2-DBS Stimulation with Medtronic Percept DBS device-Out Patient; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Parkinson's Disease
Interventions: Deep brain stimulator; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Parkinson's Disease, Mild Cognitive Impairment
Interventions: stimulation ON, stimulation OFF; Device
Lead sponsor: St. Joseph's Hospital and Medical Center, Phoenix; Other
Eligibility: 50 Years to 75 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Parkinson Disease
Interventions: DBS Programming; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota

Conditions: Essential Tremor
Interventions: Cala TWO stimulator; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tinnitus
Interventions: Deep Brain Stimulation (DBS); Device
Lead sponsor: Paul Larson; Other
Eligibility: 22 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Surgical Wound Infections
Interventions: Vancomycin, Placebo (Saline Solution); Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Epilepsy
Interventions: Memory Tasks, Attention/arousal tasks, Language tasks, Visuospatial tasks, Auditory Tasks, Brain Stimulation, Social Emotional Task, Recording of facial expressions, Judgement/Impulsivity Task; Other · Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 175 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2032
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Parkinson's Disease
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Parkinson's Disease, Essential Tremor, Dystonia
Interventions: Dexmedetomidine Hydrochloride Infusion, Normal Saline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases, Cardiovascular Diseases
Interventions: Deep Brain Stimulation (DBS) of the Motor Thalamus; Device
Lead sponsor: Jorge Gonzalez-Martinez; Other
Eligibility: 18 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Parkinson's Disease, Dystonia, Ataxia
Interventions: Deep Brain Stimulation (DBS); Procedure
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Parkinson's Disease
Interventions: Deep Brain Stimulator; Device
Lead sponsor: University of Miami; Other
Eligibility: 45 Years to 70 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Parkinson's Disease
Interventions: Deep Brain Stimulation, DBS surgery; Device · Procedure
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Major Depressive Disorder
Interventions: Deep Brain Stimulation; Device
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2024
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Obsessive-Compulsive Disorder
Interventions: Medtronic Activa Deep Brain Stimulation; Device
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 55 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Epilepsy
Interventions: RNS® System implantation, RNS® System responsive stimulation; Procedure · Device
Lead sponsor: NeuroPace; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 12
States / cities: Phoenix, Arizona • New Haven, Connecticut • Jacksonville, Florida + 8 more

Conditions: Parkinson's Disease (PD), Essential Tremor
Interventions: Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus, Multisyllabic sequence learning; Behavioral · Other
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Parkinson's Disease, Depression, Anxiety
Interventions: Not listed
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 40 Years and older
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2015
U.S. locations: 2
States / cities: St Louis, Missouri • Cincinnati, Ohio

Search by objective public record fields.

Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)

Physiology, Imaging and Modeling of Essential Tremor

Responsive Deep Brain Stimulator for Essential Tremor

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression

Thalamus Seizure Detection With a Deep Brain Stimulator System

Non-invasive Measurement of Brain Oxygen Levels in People With Subthalamic Deep Brain Stimulators

Deep Brain Stimulation of the nbM to Treat Mild Cognitive Impairment in Parkinson's Disease

Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus

Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study

Pilot Study of Deep Brain Stimulation (DBS) in Area LC for Chronic Tinnitus

Prevention of Neurosurgical Wound Infections

Human Intracranial Electrophysiology

Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease

Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Perceptual Decision Making Under Conditions of Visual Uncertainty

Deep Brain Stimulation Effects on Gait and Balance in Patients With Parkinson's Disease

Clinical Outcomes of Deep Brain Stimulator (DBS) Electrodes Placed Using Intraoperative Computed Tomography (CT) and Frameless Stereotaxis

Deep Brain Stimulation for Treatment Resistant Depression

Electrical Stimulation of the Internal Capsule for Intractable Obsessive-compulsive Disorder (OCD)

RNS® System Feasibility Study

Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)