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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:47 AM EDT

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Showing 313–336 of 4,835 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Depression Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Chronic Depression and PTSD in Stroke Patients Admitted to the Neuroscience Intensive Care Unit (NICU) and Their Family Caregivers

NCT02797509
View directory record Official record
Conditions
Neurological Disorder
Interventions
Psychosocial Skills-Based Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 17, 2018 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

NCT07351799
View directory record Official record
Conditions
Lactation, Mindfulness, NICU, Breastmilk, Neonatal, Meditation, Pumping, Breast, Cortisol, Oxytocin, Anxiety, Depression
Interventions
Standard of Care, Mindfulness-based Intervention
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 22, 2026, 10:47 AM EDT
Terminated Phase 4 Interventional Results available

Sinusitis and Facial Pain Disorders Anti-Depression Trial

NCT00754793
View directory record Official record
Conditions
Chronic Sinusitis, Facial Pain Disorder, Depression
Interventions
escitalopram, placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 17, 2014 · Synced Oct 22, 2026, 10:47 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Post-stroke Psychosocial Recovery

NCT05380037
View directory record Official record
Conditions
Stroke
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Phase 2 Interventional

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

NCT07115329
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Zelquistinel
Drug
Lead sponsor
Syndeio Biosciences, Inc
Industry
Eligibility
18 Years to 64 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
32
States / cities
Phoenix, Arizona • Tucson, Arizona • Montclair, California + 27 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Early Versus Traditional Follow-Up on Breastfeeding Rates at 6 Months

NCT02221895
View directory record Official record
Conditions
Pregnancy, Breastfeeding, Contraception, Cervical Cancer, Postpartum Depression
Interventions
Postpartum follow up appointment 2-3 weeks after delivery, Postpartum follow up 6-8wk after delivery
Other
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 50 Years · Female only
Enrollment
344 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Diabetes Prevention and Control in the Workplace: A Pilot Study

NCT00739336
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Diabetes Prevention and Control
Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Not applicable Interventional

rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression

NCT06511544
View directory record Official record
Conditions
Depression, Treatment Resistant
Interventions
Transcranial magnetic stimulation
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 2 Interventional Results available

Post-Stroke Optimization of Walking Using Explosive Resistance

NCT03826771
View directory record Official record
Conditions
Stroke, Depression
Interventions
Power training, Stretching
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional

Neurofeedback for Treatment Resistant Depression

NCT03428828
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Amygdala Neurofeedback, Parietal Neurofeedback
Device
Lead sponsor
Kymberly Young
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

PTSD Screening in Pregnant Black Women

NCT06522022
View directory record Official record
Conditions
Pregnancy Early, PTSD
Interventions
Culturally Responsive SBIRT for OB, Brief Screening for PTSD
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Atlanta, Georgia • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 4 Interventional

Carbamazepine Extended-Release for the Treatment of Bipolar Depression

NCT00203567
View directory record Official record
Conditions
Bipolar Depression
Interventions
carbamazepine ER
Drug
Lead sponsor
Tuscaloosa Research & Education Advancement Corporation
Other
Eligibility
19 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 24, 2008 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

PET Imaging of mGLuR5 With Drug Challenge

NCT01691092
View directory record Official record
Conditions
Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)
Interventions
Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
3
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychological Symptom Change in Veterans After Six Sessions of EFT (Emotional Freedom Techniques)

NCT01117545
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
EFT (Emotional Freedom Techniques)
Behavioral
Lead sponsor
Soul Medicine Institute
Other
Eligibility
18 Years to 90 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 2 Interventional Results available

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

NCT03775200
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Psilocybin
Drug
Lead sponsor
COMPASS Pathways
Industry
Eligibility
18 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
8
States / cities
La Jolla, California • San Diego, California • Stanford, California + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 2 Interventional

An 8 Week Study Of Depression In Adults Diagnosed With Major Depressive Disorder

NCT00057213
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Radafaxine
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
21
States / cities
Peoria, Arizona • Scottsdale, Arizona • Garden Grove, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 2 Interventional Results available

Zaleplon in HIV Patients With Depression

NCT03489304
View directory record Official record
Conditions
HIV/AIDS, Clinical Depression
Interventions
Zaleplon
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Phase 4 Interventional Results available

Project to Improve Symptoms and Mood in People With Spinal Cord Injury

NCT00592384
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia, Spinal Cord Injuries
Interventions
venlafaxine XR, placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 64 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
6
States / cities
Birmingham, Alabama • Miami, Florida • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Results available

Examining the Effect of EEG-guided Theta Burst Stimulation in Bipolar Disorder

NCT05179785
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS)
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 35 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 22, 2026, 10:47 AM EDT
Not listed Not applicable Interventional

Home-based Transcranial Direct Current Stimulation (tDCS) for Major Depressive Disorders (MDD)

NCT05205915
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
tDCS intervention applied by Starstim device
Device
Lead sponsor
Neuroelectrics Corporation
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
4
States / cities
Coral Springs, Florida • Miami, Florida • Snellville, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome

NCT02421276
View directory record Official record
Conditions
Down Syndrome, Polyendocrinopathies, Autoimmune, Respiratory Tract Infections, Autoimmunity
Interventions
Phlebotomy
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 22 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Oct 22, 2026, 10:47 AM EDT
Completed Not applicable Interventional Results available

Personalized Therapeutic Neuromodulation for Anhedonic Depression

NCT05144789
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Active TBS-DLPFC, Active TBS-DMPFC, Sham TBS-DLPFC or DMPFC
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

NCT04582916
View directory record Official record
Conditions
Depression
Interventions
11C-MCI, 11CPS13
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 70 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 22, 2026, 10:47 AM EDT
Recruiting Not applicable Interventional

Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

NCT04080778
View directory record Official record
Conditions
Bipolar Disorder
Interventions
magnetic seizure therapy (MST), electroconvulsive therapy (ECT)
Device
Lead sponsor
Joao L. DeQuevedo
Other
Eligibility
22 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 22, 2026, 10:47 AM EDT