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ClinicalTrials.gov public records Last synced Oct 29, 2026, 7:55 AM EDT

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Showing 1081–1104 of 4,843 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Depression Clear all
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Perimenopausal Estrogen Replacement Therapy Study

NCT01308814
View directory record Official record
Conditions
Perimenopause, Menopause, Depression
Interventions
Estradiol, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
45 Years to 60 Years · Female only
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2017 · Synced Oct 29, 2026, 7:55 AM EDT
Terminated Phase 4 Interventional Results available

Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression

NCT01794455
View directory record Official record
Conditions
Depression, Hypertension
Interventions
Sertraline, Candesartan
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
60 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 20, 2016 · Synced Oct 29, 2026, 7:55 AM EDT
Active, not recruiting Not applicable Interventional

Individualized Targeting and Neuromodulation of Late-Life Depression

NCT04543773
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
rTMS
Device
Lead sponsor
University of New Mexico
Other
Eligibility
60 Years to 79 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Not listed No phase listed Observational

Caring for the Whole Person

NCT03034369
View directory record Official record
Conditions
Behavioral Health
Interventions
Access to Care, Depression Screening, Patient-Provider Relationship, Patient-Clinic Interactions, Stigma, Provider Continuity, Symptom Severity, Diagnoses, Social support, Preventive Screening, Inpatient Hospitalization Utilization, Inpatient Readmissions, Post-Admission follow-up
Other
Lead sponsor
Providence Health & Services
Other
Eligibility
18 Years and older
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 15, 2017 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional

A Geriatric Assessment Intervention for Older Cancer Patients Receiving Chemotherapy

NCT01915056
View directory record Official record
Conditions
Cancer
Interventions
GA-driven Intervention
Other
Lead sponsor
University of Rochester
Other
Eligibility
70 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
3
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project e-PBI+ - Parent Intervention to Reduce College Student Drinking and Cannabis Use

NCT05345951
View directory record Official record
Conditions
Underage Drinking, Cannabis Use, Drinking, Teen, Drinking, College, College Drinking, Teen Drinking
Interventions
e-PBI
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 19 Years
Enrollment
1,980 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Latino Teen Depression Treatment Study

NCT05499182
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
13 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Terminated Not applicable Interventional Results available

Efficacy and Safety Study of NeuroStar TMS Therapy in Patients With Major Depressive Disorder With Postpartum Onset

NCT01842542
View directory record Official record
Conditions
Depression, Postpartum
Interventions
NeuroStar Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
Neuronetics
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Pensacola, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Phase 4 Interventional

Electroencephalography (EEG) Biomarkers of Response in Depression

NCT00759122
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
venlafaxine (Effexor), placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2008 · Synced Oct 29, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

NCT05925322
View directory record Official record
Conditions
Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions
"Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Terminated Phase 4 Interventional

Galantamine Augmentation of Escitalopram for Treatment of Depression

NCT00423969
View directory record Official record
Conditions
Depression
Interventions
Galantamine, Escitalopram
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 18, 2007 · Synced Oct 29, 2026, 7:55 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Palliative Care Needs of Children With Rare Diseases and Their Families

NCT06938542
View directory record Official record
Conditions
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome, Early Infantile Epileptic Encephalopathy, FOXG1 Syndrome, KBG Syndrome, Noonan Syndrome, Severe Hemophilia A, Short Bowel Syndrome, Beta-Propeller Protein-Associated Neurodegeneration, Brain Injury of Prematurity With Periventricular Leukomalacia, Chromosome 17p13.3 Microdeletion Syndrome, Chromosome 1q43-1q44 Deletion, Cockayne Syndrome, Congenital Diaphragmatic Hernia, End-Stage Renal Disease With Cloacal Anomaly, Mitochondrial Depletion Disorder, Severe Factor VII Deficiency
Interventions
Family Centered pediatric palliative care for family caregivers of children with rare diseases.
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
12 Months to 99 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

NCT05942469
View directory record Official record
Conditions
Burnout, Burnout, Professional, Positive Affect, Depression, Anxiety, Compassion Fatigue, Job Stress
Interventions
FOREST
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia

NCT06982820
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Prism Training
Device
Lead sponsor
GrayMatters Health Ltd.
Industry
Eligibility
22 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Providence, Rhode Island • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Depression and Anxiety Reduction Treatment for Suicide

NCT01941862
View directory record Official record
Conditions
Anxiety, Depression, Suicide
Interventions
Psychoeducation and Cognitive Bias Modification
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 29, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

Informing Implementation of a Circadian-Focused Intervention for Postpartum Depression

NCT07766161
View directory record Official record
Conditions
Postpartum Depression (PPD)
Interventions
Light therapy
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients

NCT03417583
View directory record Official record
Conditions
Huntington Disease
Interventions
Protocol Intervention Group
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 15, 2023 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Medicaid Enhanced Prenatal/Postnatal Services Using a Nurse-Community Health Worker Team

NCT00536159
View directory record Official record
Conditions
Perinatal Depression, Stress, Prenatal Health Risk Behaviors, Child Development
Interventions
Medicaid Maternal and Infant Support Services, Nurse-CHW team
Other
Lead sponsor
Michigan State University
Other
Eligibility
16 Years and older · Female only
Enrollment
613 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2007 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

The Efficacy of Cranial Electrostimulating Therapy for Depression and Anxiety Among Homeless Adults

NCT02732561
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Alpha Stim device, Sham device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lamotrigine Therapy in Geriatric Bipolar Depression

NCT00720473
View directory record Official record
Conditions
Bipolar Depression
Interventions
Lamotrigine
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
60 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Oct 29, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

NCT05566769
View directory record Official record
Conditions
Neuromyelitis Optica
Interventions
NMOSDCopilot smartphone application
Device
Lead sponsor
Ad scientiam
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
10
States / cities
Los Angeles, California • Sacramento, California • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Phase 2 Interventional Results available

Electroacupuncture for Major Depression

NCT00071110
View directory record Official record
Conditions
Depression, Depressive Disorder
Interventions
Electroacupuncture, Sham
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression

NCT02360280
View directory record Official record
Conditions
Treatment-resistant Depression
Interventions
ketamine, midazolam
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 29, 2026, 7:55 AM EDT
Completed Phase 2 Interventional

AZD6765 Severe Major Depressive Disorder (MDD) IV

NCT00781742
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
AZD6765, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 65 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
27
States / cities
Little Rock, Arkansas • Los Angeles, California • Orange, California + 24 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2012 · Synced Oct 29, 2026, 7:55 AM EDT