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ClinicalTrials.gov public records Last synced Oct 29, 2026, 10:08 PM EDT

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Showing 1129–1152 of 4,844 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Depression Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors

NCT05574127
View directory record Official record
Conditions
Survivorship
Interventions
Behavioral Activation, Supportive Psychotherapy
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
65 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2026 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Results available

tDCS for Increasing Exercise Adherence in Depressed Individuals

NCT03178903
View directory record Official record
Conditions
Depression, Physical Activity
Interventions
tDCS, Sham tDCS, Aerobic Exercise (AE)
Other · Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 27, 2023 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Phase 2 Interventional

Acupuncture as a Supplemental Treatment for Bipolar Depression

NCT00071669
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Acupuncture
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2001
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 15, 2013 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional

Patient Outcomes Reporting for Timely Assessments of Life With Depression: PORTAL-Depression

NCT03832283
View directory record Official record
Conditions
Depression, Depressive Disorder, Major
Interventions
CAD-MDD/CAT-DI screening via MyChart, CAD-MDD/CAT-DI screening during clinic visit, CAT-DI monitoring via MyChart, PHQ-9 monitoring during clinic visits
Diagnostic Test · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
4,161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2021 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

COPE for Children With Asthma: Intervention for Children With Asthma

NCT03481673
View directory record Official record
Conditions
Childhood Asthma, Childhood Anxiety Disorder, Childhood Depression
Interventions
COPE for Asthma
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
8 Years to 12 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Transphobia Among Adolescents Through a Brief Video Intervention

NCT04969003
View directory record Official record
Conditions
Transgenderism, Depression
Interventions
Short videos
Behavioral
Lead sponsor
Yale University
Other
Eligibility
14 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Results available

Testing Scalable, Single-Session Interventions for Adolescent Depression in the Context of COVID-19

NCT04634903
View directory record Official record
Conditions
Depression
Interventions
Supportive Therapy SSI, Behavioral Activation SSI, Growth Mindset SSI
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
13 Years to 16 Years
Enrollment
2,452 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 29, 2026, 10:08 PM EDT
Withdrawn Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) in Children and Adolescents With Epilepsy and Depression

NCT03368469
View directory record Official record
Conditions
Depressive Disorder, Generalized Epilepsy
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
10 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Challenge! Adolescent Obesity Prevention

NCT03103269
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Challenge! Small Group Intervention, Challenge! Environmental Intervention
Behavioral · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
10 Years and older
Enrollment
789 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 16, 2019 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Phase 3 Interventional

A Placebo- and Paroxetine-controlled Study of the Efficacy, Safety and Tolerability of Agomelatine (25 or 50 mg) in the Treatment of Major Depressive Disorder (MDD)

NCT00463242
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Agomelatine, paroxetine, placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 70 Years
Enrollment
501 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
46
States / cities
Phoenix, Arizona • National City, California • Orange, California + 40 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2020 · Synced Oct 29, 2026, 10:08 PM EDT
Not listed Phase 2 Interventional

Mood Tracker Smartphone App for Management of Emotional Distress After TBI

NCT04410770
View directory record Official record
Conditions
Emotional Distress
Interventions
Mood tracker ratings
Behavioral
Lead sponsor
Memorial Hermann Health System
Other
Eligibility
18 Years to 62 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional

IPC for University Counseling Centers

NCT03255954
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Counseling for University Counseling Centers
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 40 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional

Pilot Study in Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depression

NCT01431001
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cervel Neurotech Deep Shaped-Field repetitive transcranial magnetic stimulator (DSF-rTMS)
Device
Lead sponsor
Cervel Neurotech, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Atlanta, Georgia • Chicago, Illinois • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Oct 29, 2026, 10:08 PM EDT
Active, not recruiting Not applicable Interventional

Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression

NCT06052137
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Active TBS-DLPFC, TBS-DMPFC
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Magnetic Resonance Imaging Study of Geriatric Depression

NCT00245557
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Sertraline
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
55 Years to 89 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Behavioral vs. Interpersonal Therapy (IPT) Prevention of Depression in Adolescents

NCT00374439
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Cognitive-behavioral, Interpersonal Therapy
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
12 Years to 17 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional

A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program

NCT06042166
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Parenting Stress, Parent Child Relationships
Interventions
Connecting and Reflecting Experience (CARE) Program
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family Spirit Study

NCT00356551
View directory record Official record
Conditions
Substance Abuse
Interventions
Family Spirit curriculum
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 24 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
5
States / cities
Fort Defiance, Arizona • Tuba City, Arizona • Whiteriver, Arizona + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2016 · Synced Oct 29, 2026, 10:08 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy

NCT03889756
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ketamine infusion, Midazolam infusion
Drug
Lead sponsor
Yale University
Other
Eligibility
13 Years to 17 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Not applicable Interventional

Optimizing Care for Cancer Survivors With Depression: Project 3

NCT06930729
View directory record Official record
Conditions
Cancer, Depression
Interventions
Behavioral Activation Therapy App, Telehealth Delivered Behavioral Activation
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 29, 2026, 10:08 PM EDT
Completed Phase 2Phase 3 Interventional

Meru Health Ascend Mobile Intervention for Depression in Middle Aged and Older Adults

NCT03652948
View directory record Official record
Conditions
Depression, Depressive Symptoms
Interventions
Meru Health Ascend Program
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
40 Years to 120 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Oct 29, 2026, 10:08 PM EDT
Recruiting Phase 3 Interventional

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

NCT07573176
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Seltorexant, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 74 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
34
States / cities
Bryant, Arkansas • Bellflower, California • Glendale, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 29, 2026, 10:08 PM EDT
Active, not recruiting Not applicable Interventional

Compressed Intermittent Theta Burst Stimulation

NCT04684706
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
intermittent Theta Burst Stimulation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
La Jolla, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 29, 2026, 10:08 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive Disorder

NCT03222752
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cranial Electrotherapy Stimulation, Sham Cranial Electrotherapy Stimulation
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Forest, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 29, 2026, 10:08 PM EDT