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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:29 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Heart Failure, Insomnia, Cardiomyopathy
Interventions: Cognitive Behavioral Therapy for Insomnia (CBT-I), Heart Failure Self-Management Education; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Lung Non-Small Cell Carcinoma, Unipolar Depression
Interventions: Biospecimen Collection, Counseling, Interview, Psilocybin, Survey Administration; Procedure · Other · Drug
Lead sponsor: Alan Davis; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Mental Health Issue, Breast Cancer
Interventions: Digital Micro-Interventions; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tinnitus
Interventions: Reiki; Other
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Major Depressive Disorder
Interventions: Left DLPFC tDCS, Right DLPFC tDCS, Cognitive task; Device · Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 20 Years to 55 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Suicidal Behavior, Self-Harm, Deliberate, Suicidal Ideation, Suicide
Interventions: Stepped Care for Suicide Prevention, Zero Suicide Quality Improvement; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 12 Years to 24 Years
Enrollment: 301 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Los Angeles, California • Portland, Oregon

Conditions: Adjustment Disorder, Anxiety Disorder, Depression, Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm, Cancer
Interventions: Questionnaire Administration, Virtual Reality (VR) Intervention; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 90 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Social Activity
Interventions: oxytocin (Pitocin); Drug
Lead sponsor: Claremont Graduate University; Other
Eligibility: 50 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Depression
Interventions: Enhanced Usual Care (EUC), Supported Online Self-help for Depression (SOS-Depression); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: San Diego, California • West Los Angeles, California

Conditions: Opioid-Related Disorders
Interventions: Deep Brain Stimulation; Device
Lead sponsor: West Virginia University; Other
Eligibility: 22 Years to 50 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Post Traumatic Stress Disorder, Major Depressive Disorder
Interventions: Mindfulness-Based Cognitive Therapy; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Pulmonary Disease, Chronic Obstructive (COPD), Cognitive Impairment
Interventions: Neuropsychological Assessment, Spirometry, Arterial Blood Gas, Diffusion Capacity of the Lung for Carbon Monoxide, 6 Minute Walk Test, Systemic Vascular Measures, Blood Biomarkers, Symptom Questionnaire Measures, Brain MRI; Behavioral · Procedure · Diagnostic Test + 1 more
Lead sponsor: Karin Hoth; Other
Eligibility: 30 Years to 85 Years
Enrollment: 170 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Head and Neck Carcinoma
Interventions: Interview, Medical Device Usage and Evaluation, Questionnaire Administration, Virtual Technology Intervention; Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Duarte, California

Conditions: Perinatal Mental Health
Interventions: Behavioral Treatment; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: Not listed
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Aurora, Colorado • Portland, Oregon

Conditions: Depression, Anxiety, Physical Disability
Interventions: Comparison of a combined CBT + exercise intervention and enhanced usual care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 60 Years and older
Enrollment: 307 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 7
States / cities: Aventura, Florida • Boston, Massachusetts • Chelsea, Massachusetts + 3 more

Conditions: HIV Infections, Depression
Interventions: Bupropion, Placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older · Male only
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2004
U.S. locations: 2
States / cities: New York, New York

Conditions: Advanced Cancer, Cancer
Interventions: Behavioral Activation; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Obesity, Depression
Interventions: vCare Intervention (6-month active treatment followed by 6-month maintenance), vCare Intervention (active treatment after 6 months); Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 50 Years to 74 Years
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • St Louis, Missouri

Conditions: Self Neglect
Interventions: Benjamin Rose Institute Care Consultation (BRI-CC); Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 60 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Anxiety, Depression, Trauma, Behavior Problems
Interventions: Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, and Conduct Problems, Monitoring and Feedback System, Treatment as usual; Behavioral · Other
Lead sponsor: Harvard University; Other
Eligibility: 7 Years to 13 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Depression, Depressive Disorder, Major
Interventions: No intervention; Other
Lead sponsor: Stanford University; Other
Eligibility: 9 Years to 15 Years · Female only
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2011
U.S. locations: 2
States / cities: Stanford, California

Conditions: Music
Interventions: Rubato Life App; Device
Lead sponsor: Rubato Life; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: PTSD - Post Traumatic Stress Disorder, Insomnia, TBI (Traumatic Brain Injury)
Interventions: Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC); Drug · Behavioral
Lead sponsor: Northern California Institute of Research and Education; Other
Eligibility: 18 Years to 75 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Major Depressive Disorder (MDD)
Interventions: Rejoyn, Cognitive Behavioral Therapy (CBT) exercises; Device · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Greenwich, Connecticut • New Haven, Connecticut

Search by objective public record fields.

Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure

Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

Evaluating Digital Micro-Interventions to Reduce Distress and Increase Wellbeing in Breast Cancer Survivors

Internet-based Reiki for Tinnitus 2021

Evaluating tDCS Brain-stimulation in Depression Using MRI

Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Oxytocin and Social Behavior Over the Lifespan

Supported Online Self-Help for Veterans With Depression in Primary Care

Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

Primary-Care Based Mindfulness Intervention

COPD-Related Physiology and the Brain

Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers

The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition From Hospital to Home

Building Community Capacity for Disability Prevention for Minority Elders (Positive Minds - Strong Bodies)

Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)

Behavioral Activation-Led Activity Engagement for Cancer Empowerment

Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

Modifying a Telephone Based Care Program to Assess for Self-Neglect

Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes

Mothers With a History of Depression and Their 10-14 Year Old Daughters

Effects of an Algorithmically Enhanced Personalized Music-based Intervention in Patients With Dementia

Suvorexant 3 - PE-PC

REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness