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ClinicalTrials.gov public records Last synced Oct 28, 2026, 2:33 AM EDT

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Showing 745–768 of 4,363 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Depression Scale Clear all
Completed Phase 1 Interventional

Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients

NCT00541957
View directory record Official record
Conditions
Major Depression
Interventions
behavior therapy, Medication prescribed by PCP
Behavioral · Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Pawtucket, Rhode Island • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 8, 2011 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Phase 4 Interventional Results available

The Effect on Depressive Symptoms in ECF Residents With COPD

NCT00974246
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Depression
Interventions
Advair diskus
Drug
Lead sponsor
Valley Medical Research
Other
Eligibility
18 Years to 94 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Brooksville, Florida • Centerville, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Oct 28, 2026, 2:33 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Mindfulness-Based Intervention With a Supplement for Stress-Related Problems in College Students Across Multiple Sites (4SITE)

NCT07098845
View directory record Official record
Conditions
Stress, Mental Health, Mindfulness Based Stress Reduction
Interventions
Learning to BREATHE, Learning to BREATHE Plus, HealthEd
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
4
States / cities
Denver, Colorado • Fort Collins, Colorado • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 28, 2026, 2:33 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Postpartum Intervention for Mothers With Opioid Use Disorders

NCT05614661
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Mom Power
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Results available

Trial of Collaborative Depression Care Management for HIV Patients

NCT01372605
View directory record Official record
Conditions
Depression, HIV
Interventions
Measurement-Based Care collaborative depression management, Enhanced Usual Care
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
4
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Oct 28, 2026, 2:33 AM EDT
Completed No phase listed Observational

Perimenopause-Related Mood and Behavioral Disorders

NCT00001231
View directory record Official record
Conditions
Mood Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
40 Years to 65 Years · Female only
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1989
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress and the Sympathetic Nervous System in Adults With Depression

NCT04838262
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Acute Stressors
Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 30 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Pharmacogenetic Testing in an Outpatient Population of Patients With Depression

NCT02497027
View directory record Official record
Conditions
Depression
Interventions
pharmacogenetic testing
Other
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Phase 3 Interventional Results available

Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression

NCT02600494
View directory record Official record
Conditions
Bipolar Depression
Interventions
ITI-007 (Lumateperone), Placebo
Drug
Lead sponsor
Intra-Cellular Therapies, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
554 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
55
States / cities
Little Rock, Arkansas • Rogers, Arkansas • Cerritos, California + 52 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 28, 2026, 2:33 AM EDT
Not listed Phase 4 Interventional

Cymbalta for Depression as a Complication of Bereavement

NCT00658931
View directory record Official record
Conditions
Depression, Bereavement
Interventions
Drug treatment with Cymbalta
Drug
Lead sponsor
Jefferson Clinic, P.C.
Other
Eligibility
19 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 12, 2010 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Attachment and Biobehavioral Catch-up for Depression

NCT04050202
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Symptoms
Interventions
Attachment and Biobehavioral Catch-up (ABC) Intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Systems of Support Study for Childhood Depression

NCT01159041
View directory record Official record
Conditions
Depression
Interventions
Family Focused Treatment (FFT), Individual Treatment (IP)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
7 Years to 13 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Los Angeles, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 28, 2026, 2:33 AM EDT
Completed No phase listed Observational

Health Related QOL, Depression and Lifestyle Changes in Insulin Resistant Adolescents

NCT00493259
View directory record Official record
Conditions
Insulin Resistance, Depression
Interventions
Health-Related Quality of Life instrument, Depression Scale for Children (CES-DC)
Behavioral
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
11 Years to 17 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Results available

Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression

NCT01654796
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Low Field Magnetic Stimulation (LFMS), Sham LFMS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
Birmingham, Alabama • New Haven, Connecticut • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 5, 2017 · Synced Oct 28, 2026, 2:33 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Pilot Study Using Transcranial Electrostimulation (TESA-HB) Therapy for the Treatment of Depressive Symptoms

NCT03471754
View directory record Official record
Conditions
Mild to Moderate Depression
Interventions
TESA-HB Transcranial Electronic Stimulation Device
Device
Lead sponsor
Annecto LLC
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bensalem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 28, 2026, 2:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Long-term Observation of Participants With Mood Disorders

NCT04877977
View directory record Official record
Conditions
Depression, Suicide Risk
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 99 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 28, 2026, 2:33 AM EDT
Recruiting Not applicable Interventional

Telephone-Based Support Programs for People With Epilepsy

NCT05082181
View directory record Official record
Conditions
Epilepsy
Interventions
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), BOOST (Bringing Out Our Strength Together)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Results available

Theta Burst Stimulation in Young Adults With Depression

NCT03737032
View directory record Official record
Conditions
Depression
Interventions
Intermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation, Sham Theta Burst Stimulation
Device
Lead sponsor
Erika Forbes
Other
Eligibility
18 Years to 25 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Pilot Study in Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depression

NCT01431001
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cervel Neurotech Deep Shaped-Field repetitive transcranial magnetic stimulator (DSF-rTMS)
Device
Lead sponsor
Cervel Neurotech, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Atlanta, Georgia • Chicago, Illinois • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Phase 4 Interventional Results available

Antidepressant Plus Asenapine Versus Antidepressant Plus Placebo for Depression

NCT01670019
View directory record Official record
Conditions
Major Depressive Disorder Without Psychotic Features
Interventions
Asenapine 5-20 mg daily, Placebo 1-4 tablets daily
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Augusta, Georgia • Durham, North Carolina • Greenville, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Sleep and Healthy Aging Research Study (PRO-SHARE)

NCT01641263
View directory record Official record
Conditions
Depression
Interventions
Sleep Education Therapy, Cognitve Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dynamic Measures of Neurochemistry in Mood Disorders

NCT00178828
View directory record Official record
Conditions
Depression
Interventions
sertraline, bupropion
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sensation Awareness Focused Training for Spouses

NCT03129204
View directory record Official record
Conditions
Post Intensive Care Syndrome, Anxiety, Depression, Posttraumatic Stress Disorder, Sleep Deprivation
Interventions
SAF-T
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 28, 2026, 2:33 AM EDT
Completed Phase 4 Interventional

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

NCT00021528
View directory record Official record
Conditions
Depression
Interventions
citalopram, BuproprionSR, buspirone, Lithium, mirtazapine, nortriptyline, sertraline, tranylcypromine, VenlafaxineXR, Cognitive Therapy, T3 (Triiodothyronine)
Drug · Behavioral
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 75 Years
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
41
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2009 · Synced Oct 28, 2026, 2:33 AM EDT