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Completed Phase 4 Interventional

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

ClinicalTrials.gov ID: NCT00021528

Public ClinicalTrials.gov record NCT00021528. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 11, 2026, 3:50 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Sequenced Treatment Alternatives to Relieve Depression

Study identification

NCT ID
NCT00021528
Recruitment status
Completed
Study type
Interventional
Phase
Phase 4
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Enrollment
4,000 participants

Conditions and interventions

Conditions

Interventions

  • BuproprionSR Drug
  • Cognitive Therapy Behavioral
  • Lithium Drug
  • T3 (Triiodothyronine) Drug
  • VenlafaxineXR Drug
  • buspirone Drug
  • citalopram Drug
  • mirtazapine Drug
  • nortriptyline Drug
  • sertraline Drug
  • tranylcypromine Drug

Drug · Behavioral

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 30, 2001
Primary completion
Not listed
Completion
Aug 31, 2006
Last update posted
Sep 24, 2009

2001 – 2006

United States locations

U.S. sites
41
U.S. states
13
U.S. cities
23
Facility City State ZIP Site status
Birmingham VA Medical Center Birmingham Alabama 35223
Tuscaloosa VA Mental Health Clinic - Veterans Only Tuscaloosa Alabama 35404
Tuscaloosa VA Primary Care Center Tuscaloosa Alabama 35404
Psychiatric Centers at San Diego Chula Vista California 91910
Harbor UCLA Family Health Care Center Harbor City California 90710
UCLA General Outpatient Psychiatry Clinic Los Angeles California 90024
UCLA Internal Medicine Clinic Los Angeles California 90024
UCSD Outpatient Psychiatric Services San Diego California 92103
Veterans Affairs Medical Center/FIRM Primary Care Clinic San Diego California 92161
Harbor UCLA Medical Center Torrance California 90509
Northwestern Outpatient Treatment Care Center Chicago Illinois 60611
University of Illinois at Chicago Clinic Chicago Illinois 60612
Evanston Outpatient Clinic Evanston Illinois 60201
COMCARE of Sedgwick County Wichita Kansas 67203
Psychiatric Outpatient Clinic Wichita Kansas 67214-2878
Swampscott Family Doctors Boston Massachusetts 01907
Internal Medicine Associates Boston Massachusetts 02114
MGH/Charlestown Clinic Charlestown Massachusetts 02129
MGH/Salem Professional Salem Massachusetts 01970
General Psychiatric Ambulatory Clinic Ann Arbor Michigan 48105-0722
Briarwood Family Practice Clinic Ann Arbor Michigan 48109-0708
LIJ/Zucker Hillside Adult Ambulatory Care Center Glen Oaks New York 11004
LIJ North Shore Medical Group Lake Success New York 11040
UNC Chapel Hill General Medicine Clinic Chapel Hill North Carolina 27599-7110
UNC Chapel Hill Adult Diagnostic & Treatment Clinic Chapel Hill North Carolina 27599-7160
UNC Chapel Hill Family Practice Clinic Chapel Hill North Carolina 27955
Springer Family Medicine Tulsa Oklahoma 74135
Laureate Psychiatric Clinic & Hospital Tulsa Oklahoma 74136
Warren Clinic Tulsa Oklahoma 74136
Diversified Human Services Clinic Pittsburgh Pennsylvania 15062
Latterman Family Health Center Pittsburgh Pennsylvania 15132
Bellefield Clinic of WPIC Pittsburgh Pennsylvania 15213
AMPN Corkery, Heise & Dainesi Upper Saint Clair Pennsylvania 15317
Psychiatric Consultants, P.C. Nashville Tennessee 37203
Vanderbilt University Medical Center-Mental Health Center Nashville Tennessee 37212
Vine Hill Community Clinic Nashville Tennessee 37212
Centerstone/Luton Mental Health Services Nashville Tennessee 37217
The Holiner Psychiatric Group Dallas Texas 75230
UT Southwestern Family Medicine Clinic Dallas Texas 75390
MCV Primary Care Clinic Richmond Virginia 23220
MCV Family Counseling Richmond Virginia 23298-0268

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00021528, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 24, 2009 · Synced May 11, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT00021528 live on ClinicalTrials.gov.

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