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ClinicalTrials.gov public records Last synced Nov 15, 2026, 10:10 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Diode Laser Treatment Clear all

Conditions: Depression, Major Depressive Disorder
Interventions: Transcranial Light Therapy, Sham Transcranial Light Therapy; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Boston, Massachusetts • Orangeburg, New York

Conditions: Adipose Tissue Atrophy
Interventions: Venus Bliss; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 5
States / cities: Los Altos, California • Sacramento, California • Santa Monica, California + 2 more

Conditions: Peripheral Neuropathy
Interventions: Diode Laser fiber type Selective Stimulator, ZTlido 1.8 % Topical System, PeriCam PSI NR, Medoc Quantitative Sensory Testing, Inactive Topical System; Procedure · Drug · Diagnostic Test + 1 more
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Palo Alto, California • Salt Lake City, Utah

Conditions: Melasma
Interventions: Fractional 1927nm Low-Powered Diode Laser, Topical Cysteamine; Device · Other
Lead sponsor: UnionDerm; Other
Eligibility: 18 Years to 74 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Skin Texture, Pigmented Lesions
Interventions: Nonablative Fractional Diode Laser; Device
Lead sponsor: Candela Corporation; Industry
Eligibility: 21 Years to 70 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Marlborough, Massachusetts

Conditions: Rhinosinusitis
Interventions: Laser + ICG, Laser only; Device
Lead sponsor: New York Head & Neck Institute; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 3
States / cities: New York, New York

Conditions: Glaucoma
Interventions: Baerveldt Glaucoma Implant 350-mm2 / BG101-350, Transscleral Diode Laser Cyclophotocoagulation, Ahmed Model FP7 Flexible Plate, Baerveldt Glaucoma Implant 250-mm2 / BG103-250; Device · Procedure
Lead sponsor: Robert Feldman; Other
Eligibility: 18 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 23
States / cities: La Jolla, California • Los Angeles, California • Miami, Florida + 18 more

Conditions: Healthy Participants, Mild Cognitive Impairment
Interventions: LLLT, Placebo; Device
Lead sponsor: University of Texas at Austin; Other
Eligibility: 45 Years and older
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Body Contouring
Interventions: Erchonia ML Scanner (MLS), Sham device; Device
Lead sponsor: Erchonia Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 3
States / cities: Palm Beach Gardens, Florida • Marion, Indiana • Bloomfield Hills, Michigan

Conditions: Peri-orbital Wrinkles, Peri-oral Wrinkles
Interventions: Illuiminage ® Diode Laser; Device
Lead sponsor: Cynosure, Inc.; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Westford, Massachusetts

Conditions: Fat Atrophy
Interventions: 1060nm Diode laser; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Sacramento, California • Dallas, Texas

Conditions: Pain Related to TMD
Interventions: THOR® laser system; Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 99 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Subcutaneous Fat Disorder
Interventions: Venus Bliss; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 3
States / cities: Denver, Colorado • Foxborough, Massachusetts • Woodmere, New York

Conditions: Spinal Fusion, Chronic Lower Back Pain
Interventions: Laser Diode Brace, Sham Laser Diode Brace; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Musculoskeletal Pain
Interventions: Erchonia EVRL; Device
Lead sponsor: Erchonia Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Largo, Florida • White Plains, New York

Conditions: Onychomycosis
Interventions: Diode Laser Treatment; Device
Lead sponsor: ConBio, a Cynosure Company; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 2
States / cities: New London, Connecticut • Westbrook, Connecticut

Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory, Diode Laser fiber type Selective Stimulator, Quantitative sensory testing, Conditioned pain modulation efficiency, Spontaneous pain at baseline on 0-10 Numerical Rating Scale (NRS); Other · Procedure
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Mandible; Deformity, Surgical Healing, Orthognathic Surgery, Nerve Injury
Interventions: Low-level laser therapy, Dummy LLLT; Device
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 15 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Keratosis Pilaris (KP)
Interventions: Diode Laser; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Reversible Pulpitis, Caries
Interventions: Formocresol application after pulpotomy preparation, GENTLEray 980 Soft Tissue diode laser; Procedure
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 3 Years to 8 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Adipose Tissue Atrophy
Interventions: Venus Bliss; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Beverly Hills, California • Dallas, Texas

Conditions: Hair Removal
Interventions: LightSheer Duet HS handpiece; Device
Lead sponsor: Lumenis Be Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions: Photobiomodulation with a super-luminous light emitting diode; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Malignant Solid Neoplasm
Interventions: Biospecimen Collection, Computed Tomography, Endobronchial Ultrasound Bronchoscopy, Interstitial Photodynamic Therapy, Palliative Radiation Therapy, Physical Performance Testing, Questionnaire Administration, Verteporfin, Laser: ML7710-PDT; Procedure · Radiation · Other + 2 more
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Buffalo, New York • Philadelphia, Pennsylvania

Search by objective public record fields.

Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3)

Clinical Evaluation of a 1060 nm Diode Laser, PEMF and Vacuum Assisted MP RF for Non-invasive Fat Reduction

Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.

Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma

Nonablative Fractional Diode Laser for Treatment of Skin Resurfacing and Pigmented Lesions

Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents

The American Glaucoma Society (AGS) Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study (ASSISTS)

Cognitive Enhancement Through Transcranial Laser Therapy

Study of Low Level Laser Therapy for Body Contouring

Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser

Clinical Evaluation of the Safety and Efficacy of a 1060 nm Diode Laser (Flanks)

Photobiomodulation for Management of Temporomandibular Disorder Pain

Subject Evaluation of a 1064nm Diode Laser/RF

Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery

The Effect of Low Level Laser Therapy on Neck and Shoulder Pain

Diode Laser Treatment of Onychomycosis

A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)

LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery

Treatment of Keratosis Pilaris With 810 nm Diode Laser

Electrical and Formocresol Pulpotomy in Primary Molars

Analysis of the Performance of 1060 nm Diode and Radio Frequency Prior to Abdominoplasty

Clinical Evaluation of LightSheer Duet 805nm HS Handpiece

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction