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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: E-cigarette e-liquid Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

NCT05423340
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
E-cigarette Flavor, Tobacco Free Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 28, 2026, 4:31 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

NCT05962229
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Vaping
Interventions
(S)-Nicotine, (R)- nicotine, Racemic nicotine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes and Blood Vessel Function

NCT02740595
View directory record Official record
Conditions
Nicotine Dependence
Interventions
one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

NCT04449510
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Results available

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

NCT05932693
View directory record Official record
Conditions
E-Cig Use
Interventions
E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%), E-liquid coolant (WS-3, 1.0%), E-liquid coolant (WS-3, 2.0%), E-liquid coolant (menthol, 0.05%), E-liquid coolant (menthol, 0.1%), E-liquid coolant (menthol, 0.5%), E-liquid coolant (menthol, 1.0%), E-liquid coolant (menthol, 2.0%), E-liquid coolant (WS-23, 0.05%), E-liquid coolant (WS-23, 0.1%), E-liquid coolant (WS-23, 0.5%), E-liquid coolant (WS-23, 1.0%), E-liquid coolant (WS-23, 2.0%), E-liquid coolant (WS-23, 4.0%)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

NCT04231539
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, Vaporizer Device, Salt-HIgh Nicotine Unflavored (Product B), Free-Low Nicotine Tobacco Flavored (Product C), Salt-High Nicotine Tobacco Flavored (Product D)
Drug · Device
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Vaping THC From Electronic Cigarettes

NCT02955329
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Nicotine, Cannabis, PAX Loose Leaf Vaporizer
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-cig Perception: Study 1

NCT05432830
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions
E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-Cigarettes and SNA

NCT02724241
View directory record Official record
Conditions
Nicotine Dependence
Interventions
one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2021 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Phase 1 Interventional Results available

Effects of E-Cigarette Flavors on Adults TCORS 2.0

NCT03635333
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Nicotine, Flavor
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

NCT04053868
View directory record Official record
Conditions
Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions
JUUL, Tobacco
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes Plus Electronic Cigarettes

NCT04058717
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants

NCT03379740
View directory record Official record
Conditions
Vaping, Nicotine Absorption
Interventions
E-cigarette, P4M3-1.7%, P4M3-1.7%LA, P4M3-3%LA, P4M3-4%LA
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
21 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2019 · Synced Sep 28, 2026, 4:31 PM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sensory Perception of Sweet Flavors in E-Cigarette

NCT03332953
View directory record Official record
Conditions
Smoking
Interventions
E-cigarettes with varying concentrations of nicotine & flavor
Other
Lead sponsor
Oregon State University
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers

NCT05960305
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P1213416, P1213422, P1213716, P1213722, P1211216, P1211222, P1213616, P1213622, P1213816, P1213822, P1211916, P1211922
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
1,845 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
12
States / cities
Phoenix, Arizona • Fort Lauderdale, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Sep 28, 2026, 4:31 PM EDT
Withdrawn Not applicable Interventional

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

NCT04258852
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Low strength nicotine e-liquid, High strength nicotine e-liquid
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Not applicable Interventional Results available

E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia

NCT02918630
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Nicotine Patch, E-cigarette
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 28, 2026, 4:31 PM EDT
Completed No phase listed Observational

Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)

NCT04794543
View directory record Official record
Conditions
Hiv, Lung Injury
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Baton Rouge, Louisiana • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 25, 2024 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Early Phase 1 Interventional Results available

Effects of Flavors on Nicotine Reinforcement in Smokers

NCT03243630
View directory record Official record
Conditions
Nicotine Dependence
Interventions
IV nicotine, Menthol flavor, green apple, green apple and menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 28, 2026, 4:31 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

NCT03691350
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 52 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 28, 2026, 4:31 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

NCT02612701
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Perfusion
Interventions
Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid)
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 49 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 28, 2026, 4:31 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

NCT06208202
View directory record Official record
Conditions
Abuse Tobacco, Exposure
Interventions
Behavioral Intervention, Biospecimen Collection, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 28, 2026, 4:31 PM EDT