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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: ECIG Clear all
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

NCT06856525
View directory record Official record
Conditions
Electronic Cigarette Related Lung Damage
Interventions
Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test, Chest CT
Drug · Diagnostic Test
Lead sponsor
Y. Michael Shim, MD
Other
Eligibility
18 Years to 35 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2032
U.S. locations
2
States / cities
Durham, North Carolina • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

NCT05971823
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 8, 2026, 5:40 PM EDT
Active, not recruiting Not applicable Interventional

Respiratory Effects of E-Cigarettes in Obese Youth

NCT05869318
View directory record Official record
Conditions
E-Cig Use
Interventions
ECIG own, ECIG Vuse
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing Electronic Cigarette Nicotine Flux

NCT04378907
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Cigarette Smoker/ECIG users: 0 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 6 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 15 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 30 mg/ml nicotine concentration
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 8, 2026, 5:40 PM EDT
Not yet recruiting Phase 4 Interventional

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

NCT07786896
View directory record Official record
Conditions
E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions
Nicotine Replacement Therapies, Brief Behavioral Counseling
Drug · Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Greenville, North Carolina • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Impact of Electronic Cigarettes on Perinatal Immune Responsiveness and Birth Outcomes

NCT02553577
View directory record Official record
Conditions
Immune Response, Birth Weight, Gestational Age
Interventions
Not listed
Lead sponsor
Kristin Ashford
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

NCT03861078
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Results available

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

NCT05458895
View directory record Official record
Conditions
E-cigarette Use
Interventions
ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

NCT02964182
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dual Use Approach Bias Training for Nicotine Addiction

NCT05306158
View directory record Official record
Conditions
Tobacco Smoking, Electronic Cigarette Use, Substance Use
Interventions
CC+ECIG Condition, CC Condition, Sham Condition
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects

NCT02500615
View directory record Official record
Conditions
Nicotine Exposure, Nicotine Withdrawal Suppression
Interventions
ECIG liquid vehicles
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional

Acute Effects of TCIG vs ECIG in PLWH

NCT04568395
View directory record Official record
Conditions
E Cigarette Use, Vaping, Smoking, Tobacco Smoking, Nicotine Use Disorder, Qt Interval, Variation in, HIV I Infection, Oxidative Stress, Inflammation
Interventions
TCIG, ECIG, sham control
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Moment Study: Mixed Method E-cigarette Study

NCT02261363
View directory record Official record
Conditions
Smoking
Interventions
Ecig group 1
Other
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects

NCT03496116
View directory record Official record
Conditions
Nicotine Dependence
Interventions
ECIG Session
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 8, 2019 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

NCT03625986
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users

NCT03710590
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
ECIG Lab Session 15 watts, 10 mg nicotine, ECIG Lab Session 15 watts, 15 mg nicotine, ECIG Lab Session 15 watts, 30 mg nicotine, ECIG Lab Session 30 watts, 10 mg nicotine, ECIG Lab Session 30 watts, 15 mg nicotine, ECIG Lab Session 30 watts, 30 mg nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Determination of Liquid Flavor and Nicotine Form Outcomes

NCT05587504
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
E-cigarette with sweetness type 1 and pronation level 1, E-cigarette with sweetness type 1 and pronation level 2, E-cigarette with sweetness type 2 and pronation level 1, E-cigarette with sweetness type 2 and pronation level 2
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 8, 2026, 5:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

E-Cigarettes: Dynamic Patterns of Use and Health Effects

NCT02527980
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
No intervention: observation only
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Randomized Controlled Trial Methods for Novel Tobacco Products Evaluation

NCT02342795
View directory record Official record
Conditions
Nontherapeutic
Interventions
e-cigarette, cigarette substitute
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 65 Years
Enrollment
520 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Hershey, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 8, 2026, 5:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

NCT03905928
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 8, 2026, 5:40 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers

NCT02848586
View directory record Official record
Conditions
Lung Inflammation, HIV Seropositivity
Interventions
ECIGS, mobile contingency management (mCM), Usual brand
Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 8, 2026, 5:40 PM EDT