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ClinicalTrials.gov public records Last synced Nov 7, 2026, 4:30 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 98 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Exparel infiltration Clear all

Conditions: Total Knee Arthroplasty, Post-operative Pain Control
Interventions: Liposomal Bupivacaine Peri-articular Injection, Adductor canal block; Procedure
Lead sponsor: Good Samaritan Regional Medical Center, Oregon; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Corvallis, Oregon

Conditions: Pain, Postoperative
Interventions: Bupivacaine, liposomal bupivacaine; Drug
Lead sponsor: Knight, Richard, M.D.; Individual
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: San Antonio, Texas

Conditions: Rotator Cuff Tears
Interventions: Liposomal bupivacaine, Bupivacaine Hcl 0.25% Inj; Drug
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Benign Neoplasm
Interventions: Liposomal bupivacaine, Bupivacaine Hydrochloride; Drug
Lead sponsor: Samaritan Health Services; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Corvallis, Oregon

Conditions: Pain, Postoperative
Interventions: Combined Bupivacaine and Exparel, Normal Saline (NS); Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain, Postoperative, Opioid Use
Interventions: Exparel, Saline infiltration; Drug · Other
Lead sponsor: Wright State University; Other
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Dayton, Ohio

Conditions: Fracture of Shoulder and Upper Arm
Interventions: 1.3% Liposomal Bupivacaine, 0.125% Bupivacaine; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Dearborn, Michigan

Conditions: Pain
Interventions: Liposomal bupivacaine, Inter-scalene nerve block, Ropivacaine; Drug · Procedure
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Pain, Postoperative, Surgical Procedure, Unspecified
Interventions: Liposomal Bupivacaine, Bupivacaine HCl; Drug
Lead sponsor: AdventHealth; Other
Eligibility: 18 Years and older · Female only
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Post-operative Pain
Interventions: Liposome Bupivacaine, Bupivacaine HCl; Drug
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 74 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Valley Stream, New York

Conditions: Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
Interventions: Exparel Injectable Product, Bupivacaine Hydrochloride; Drug
Lead sponsor: Kathirvel Subramaniam; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Postoperative Pain
Interventions: Exparel with Bubivacaine, Bupivacaine only; Drug
Lead sponsor: Jefferson Drapkin; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
Interventions: TAP Block, Surgical Site Infiltration, Exparel; Procedure · Drug
Lead sponsor: Danbury Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Danbury, Connecticut

Conditions: Pain, Postoperative, Shoulder Osteoarthritis
Interventions: local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block; Drug · Other
Lead sponsor: TriHealth Inc.; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Post Operative Pain, Spinal Fusion
Interventions: Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 10 Years to 17 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Postoperative Pain
Interventions: Plain bupivacaine, Liposomal bupivacaine; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 80 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Cardiothoracic Surgery
Interventions: Liposomal bupivacaine, 0.25% Bupivacaine with epinephrine; Drug
Lead sponsor: Florida Heart and Lung Institute; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Hemorrhoid
Interventions: Exparel, Bupivacaine HCl with Epinephrine, Normal Saline; Drug
Lead sponsor: St. Luke's-Roosevelt Hospital Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Bariatric Surgery Analgesia
Interventions: Liposomal Bupivacaine TAP block, Bupivacaine TAP block; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 219 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Acute Pain
Interventions: Liposomal Bupivacaine, Bupivacaine, Ultrasound, Epinephrine, acetaminophen, ibuprofen, Oxycodone; Drug · Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older · Female only
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pain
Interventions: EXPAREL, Ketorolac, laparoscopic abdominal hernia repair, an open surgery for abdominal hernia repair; Drug · Procedure
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Bowel Obstruction
Interventions: IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension); Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Riverdale, Georgia

Conditions: Hernia
Interventions: EXPAREL; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: ACL, Postoperative Pain
Interventions: Exparel 30 mL, 0.5% bupivacaine, Dexamethasone, iPACK block; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Search by objective public record fields.

Adductor Canal Block Versus Liposomal Bupivacaine in TKA

Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery

Measuring Opioid Use After Rotator Cuff Repair: Comparing the Effects of Standard vs. Extended-release Nerve Blocks

Liposomal Bupivacaine in Benign Soft Tissue Tumor Resection

Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy

Liposomal Bupivacaine After Cesarean Delivery

Exparel for Postoperative Pain Management in Shoulder Surgery

Liposomal Bupivacaine in Total Shoulder Arthroplasty

Randomized Trial of Wound Infiltration With Extended-release Bupivacaine Before Laparoscopic or Robotic Hysterectomy

Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial

Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision

Effective Pain Management During Shoulder Replacement Surgery With EXPAREL

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management

Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery

Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy

Liposomal Bupivacaine in Bariatric Surgery

TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

Adult Patients Undergoing Open Colectomy MA402S23B303

EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair

Exparel vs Block for ACL Reconstruction