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ClinicalTrials.gov public records Last synced Sep 5, 2026, 9:54 PM EDT

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Showing 1–24 of 94 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Extracellular Matrix Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Blood Nitrate/Nitrite Concentrations Following Acute Ingestion of Resync in Men and Women

NCT04125940
View directory record Official record
Conditions
Healthy
Interventions
Resync, Resync + Collagen, Placebo
Dietary Supplement · Other
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 5, 2026, 9:54 PM EDT
Recruiting Phase 4 Interventional

A Prospective, Randomized, Assessor-Blinded, Multicenter Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction

NCT07657182
View directory record Official record
Conditions
Peripheral Nerve Injury, Peripheral Nerve Discontinuity, Mixed Peripheral Nerve Injury, Motor Peripheral Nerve Injury, Upper Extremity Nerve Injury
Interventions
Avance Nerve Graft, Sural nerve autograft
Biological · Procedure
Lead sponsor
Axogen Corporation
Industry
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

In-Vivo Assessment of Adipose Allograft Extracellular Matrix in Abdominoplasty Patients

NCT02845180
View directory record Official record
Conditions
Obesity
Interventions
Adipose Allograft Extracellular Matrix (AAM) Injection
Procedure
Lead sponsor
Musculoskeletal Transplant Foundation
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Sep 5, 2026, 9:54 PM EDT
Completed No phase listed Observational

Effect of MitraClip on Acute and Chronic Reverse Cardiac Remodeling Assessed by CMR: The MITRA-REVERSE Study

NCT02924363
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cardiac MRI with or without contrast dye, Blood sample
Diagnostic Test
Lead sponsor
Dipan Shah
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Atlanta, Georgia • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Terminated Not applicable Interventional Results available

TECR & ECM Placement for Esophageal High Grade Dysplasia

NCT02396745
View directory record Official record
Conditions
Barrett Esophagus, Esophagus, High Grade Dysplasia
Interventions
Subjects undergoing TECR with ECM placement (ACell MatriStem, Boston Scientific WallFlex))
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 80 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2019 · Synced Sep 5, 2026, 9:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

EndovascuLar RegIstry Evaluating SafeTy, Efficacy and Patient Comfort (ELITE)

NCT03412942
View directory record Official record
Conditions
Vascular Diseases
Interventions
FISH SP
Device
Lead sponsor
Morris Innovative Incorporated
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
3
States / cities
Gainesville, Florida • Leawood, Kansas • Robbinsdale, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 5, 2026, 9:54 PM EDT
Active, not recruiting Not applicable Interventional

Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends

NCT04865679
View directory record Official record
Conditions
Symptomatic Neuroma, Amputation, Chronic Nerve Pain
Interventions
Axoguard Nerve Cap®
Device
Lead sponsor
Axogen Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts • Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bioactive Split Thickness Skin Allograft Versus Standard of Care in the Treatment of Diabetic Foot Ulcers

NCT04040426
View directory record Official record
Conditions
Diabetic Foot, Ulcer Foot
Interventions
Human split thickness skin allograft, Additional Outer Dressing Applicaiton, Offloading, Fibracol Wound Dressing
Other
Lead sponsor
Professional Education and Research Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
5
States / cities
San Francisco, California • O'Fallon, Illinois • Youngstown, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

NCT05383508
View directory record Official record
Conditions
Nicotine Vaping, Nicotine, Vaping
Interventions
CA35, CM35, Cig
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
24 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Sep 5, 2026, 9:54 PM EDT
Not yet recruiting No phase listed Observational

PET/MRI of Primary Sclerosing Cholangitis

NCT06252610
View directory record Official record
Conditions
PSC
Interventions
Radiotracer Injection, Contrast Media, Magnetic Resonance, Imaging
Drug · Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Phase 1 Interventional

Endostatin in Treating Patients With Advanced Refractory Solid Tumors

NCT00004872
View directory record Official record
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
recombinant human endostatin
Biological
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 120 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2000
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Sep 5, 2026, 9:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Alveolar Ridge Preservation Following Tooth Extraction.

NCT05505084
View directory record Official record
Conditions
Tooth Fractures, Tooth Extraction Status Nos, Caries
Interventions
Tooth extraction and ridge preservation using different barrier mermbranes
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional

Clinical Study Evaluating Wound Closure With Endoform™ and Symphony™

NCT06035523
View directory record Official record
Conditions
Wound Healing, Diabetic Foot, Chronic Foot Ulcer, Foot Ulcer
Interventions
Endoform™ Antibacterial, Endoform™ Natural, Symphony™
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Hollywood, Florida • Miami, Florida • Salem, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Terminated No phase listed Observational Results available

The Management of Pilonidal Wounds With ACell MicroMatrix® and Cytal® Wound Matrix: A Case Series

NCT04041037
View directory record Official record
Conditions
Pilonidal Disease
Interventions
Wound Sheet Matrix 2-Layer and Powder Urinary Bladder Matrix
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Sep 5, 2026, 9:54 PM EDT
Terminated Not applicable Interventional Results available

Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care

NCT03626623
View directory record Official record
Conditions
Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Interventions
Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
Device · Other
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Fresno, California • New Orleans, Louisiana • Hyattsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2021 · Synced Sep 5, 2026, 9:54 PM EDT
Terminated Phase 1 Interventional

Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage

NCT05082831
View directory record Official record
Conditions
Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
Interventions
microfracture surgery + HST003
Biological
Lead sponsor
Histogen
Industry
Eligibility
18 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Vail, Colorado • Bradenton, Florida • Bethesda, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Sep 5, 2026, 9:54 PM EDT
Withdrawn Not applicable Interventional

Musculotendinous Tissue Unit Repair and Reinforcement (MTURR) Coordinating Center

NCT01497678
View directory record Official record
Conditions
Traumatic Injury, Muscle Injury, Tendon Injury, Soft Tissue Injury, Extremity Injury
Interventions
Extracellular Matrix
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2016 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional Results available

Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers

NCT04918784
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Restrata®, Wound Dressing
Device
Lead sponsor
Acera Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hoffman Estates, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of CollaRx® Bupivacaine Implant in Men After Open Laparotomy Herniorrhaphy

NCT01220024
View directory record Official record
Conditions
Herniorrhaphy, Postoperative Pain, Inguinal Hernia
Interventions
Bupivacaine Collagen Sponge, Placebo collagen Sponge
Drug
Lead sponsor
Innocoll
Industry
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Sep 5, 2026, 9:54 PM EDT
Completed No phase listed Observational

A Retrospective, Observational Study of the Real-world Safety and Performance of InnovaMatrix® AC at a Single Centre

NCT07170566
View directory record Official record
Conditions
Wound Heal
Interventions
innovaMatrix AC
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years to 100 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 5, 2026, 9:54 PM EDT
Recruiting Phase 2 Interventional

Phase 2 Clinical Trial of CartiLife® in the United States

NCT04744402
View directory record Official record
Conditions
Articular Cartilage Defect, Articular Cartilage Degeneration
Interventions
Autologous Chondrocyte Implantation (CartiLife®)
Drug
Lead sponsor
Biosolution Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Irvine, California • La Mesa, California • Lafayette, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Sep 5, 2026, 9:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer

NCT04753359
View directory record Official record
Conditions
Colorectal Cancer, Diet Habit
Interventions
Med, WL
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
45 Years to 75 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Recruiting No phase listed Observational

Myriad™ Augmented Soft Tissue Reconstruction Registry

NCT05243966
View directory record Official record
Conditions
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
Interventions
Myriad Matrix™ and Myriad Morcells™
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
15
States / cities
Phoenix, Arizona • Los Angeles, California • Fort Myers, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 5, 2026, 9:54 PM EDT
Terminated No phase listed Observational Results available

Cytal® Wound Matrix and MicroMatrix® Wound Study

NCT03632954
View directory record Official record
Conditions
Wounds
Interventions
ACell Arm
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Long Island City, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Sep 5, 2026, 9:54 PM EDT