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Showing 1–24 of 65 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Extracorporeal Membrane Oxygenation Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Cerebral Oxygen Metabolism in Children

NCT04157179
View directory record Official record
Conditions
Sickle Cell Disease, Cerebral Stroke
Interventions
Carbon Dioxide
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
3 Years to 50 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 25, 2026, 10:55 PM EDT
Completed No phase listed Observational

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

NCT05426083
View directory record Official record
Conditions
Acute Coronary Syndrome, Cardiogenic Shock
Interventions
Physiological Assessment
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Immersive Mixed Reality Simulation to Evoke Empathy

NCT06351397
View directory record Official record
Conditions
Educational Problems
Interventions
Mixed Reality (MR), Control
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 25, 2026, 10:55 PM EDT
Completed No phase listed Observational

Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO

NCT00371241
View directory record Official record
Conditions
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
1 Day to 30 Days
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Sep 25, 2026, 10:55 PM EDT
Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

NCT05440851
View directory record Official record
Conditions
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT
Other · Drug
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
6,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
26
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 25, 2026, 10:55 PM EDT
Completed No phase listed Observational Results available

Inflammatory Cytokine Quantification in Infants

NCT01155830
View directory record Official record
Conditions
Sepsis, Congenital Diaphragmatic Hernia, Neonatal Cardiopulmonary Failure
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
Up to 2 Months
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Sep 25, 2026, 10:55 PM EDT
Withdrawn No phase listed Observational

Quality of Life Following ECMO

NCT02809703
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation, Quality of Life
Interventions
Survey Questions
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2019 · Synced Sep 25, 2026, 10:55 PM EDT
Recruiting Not applicable Interventional

ECMO ABI Detection With Hyperfine

NCT06469801
View directory record Official record
Conditions
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
Interventions
Hyperfine
Device
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
0 Days to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Not applicable Interventional Results available

CytoSorb Reduction of Free Hemoglobin During Cardiac Surgery

NCT02566525
View directory record Official record
Conditions
Elective Cardiac Surgery
Interventions
CytoSorb
Device
Lead sponsor
CytoSorbents, Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
8
States / cities
Lexington, Kentucky • Baltimore, Maryland • Springfield, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Sep 25, 2026, 10:55 PM EDT
Terminated Not applicable Interventional Results available

Advanced Reperfusion Strategies for Refractory Cardiac Arrest

NCT03880565
View directory record Official record
Conditions
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia, Out-Of-Hospital Cardiac Arrest
Interventions
Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Phase 1 Interventional

Pharmacokinetics/Pharmacodynamics (PK/PD) of Fluconazole in Children on Extracorporeal Membrane Oxygenation (ECMO)

NCT01169402
View directory record Official record
Conditions
Cardiopulmonary Arrest, Fungal Infection
Interventions
Fluconazole
Drug
Lead sponsor
Michael Cohen-Wolkowiez
Other
Eligibility
Up to 18 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2017 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Phase 1 Interventional

Cefiderocol PK in Patients on ECMO

NCT04995835
View directory record Official record
Conditions
Sepsis
Interventions
Cefiderocol
Drug
Lead sponsor
Joseph L. Kuti, PharmD
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Hartford, Connecticut • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Phase 1 Interventional Results available

Imipenem/Cilastatin/Relebactam PK in ECMO

NCT04493151
View directory record Official record
Conditions
Sepsis
Interventions
Imipenem, Cilastatin and Relebactam
Drug
Lead sponsor
Joseph L. Kuti, PharmD
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Not applicable Interventional Results available

Pharmacokinetic Alterations During ECMO

NCT01938079
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Ketamine, Sedative drug regimen
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Not applicable Interventional

Generating Evidence in ECMO Ventilation Strategies

NCT05708365
View directory record Official record
Conditions
ARDS, Acute Respiratory Failure
Interventions
Standard-Lung Protective Ventilation, Ultra-Lung Protective Ventilation
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Sep 25, 2026, 10:55 PM EDT
Active, not recruiting Phase 4 Interventional

Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study

NCT04496362
View directory record Official record
Conditions
ECMO, Heparin, Respiratory Failure
Interventions
subcutaneous heparin anticoagulation
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Phase 4 Interventional Results available

Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO

NCT03318393
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation Complication, Pediatric ALL, Anticoagulants
Interventions
Bivalirudin, Unfractionated heparin
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
1 Day to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Sep 25, 2026, 10:55 PM EDT
Enrolling by invitation Not applicable Interventional

Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure

NCT06938217
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
Interventions
Low-flow ECMO
Device
Lead sponsor
Institute for Extracorporeal Life Support
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Sep 25, 2026, 10:55 PM EDT
Not listed No phase listed Observational

The Impact of Age-dependent Haptoglobin Deficiency on Plasma Free Hemoglobin Levels During Extracorporeal Membrane Oxygenation Support

NCT03472768
View directory record Official record
Conditions
Respiratory Failure
Interventions
Plasma Haptoglobin Concentration
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 25, 2026, 10:55 PM EDT
Withdrawn Not applicable Interventional

Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.

NCT02966080
View directory record Official record
Conditions
Acute Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Bleeding
Interventions
HEP-IV
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 20, 2017 · Synced Sep 25, 2026, 10:55 PM EDT
Enrolling by invitation Early Phase 1 Interventional

Exercise Rehabilitation in Patients With Severe Cardiopulmonary Dysfunction on Extracorporeal Life Support

NCT06792617
View directory record Official record
Conditions
ExtraCorporeal Membrane Oxygenation (ECMO), Cardiopulmonary Function, Rehabilitation
Interventions
Mobility (Central or Femoral Cannulation), Resistance Training
Other
Lead sponsor
Institute for Extracorporeal Life Support
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Sep 25, 2026, 10:55 PM EDT
Completed No phase listed Observational

Impact of Cannulation Strategy on Neurologic Injury in Infants With Respiratory Failure

NCT06079034
View directory record Official record
Conditions
Respiratory Failure
Interventions
Venovenous ECMO, Venoarterial ECMO
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
0 Days and older
Enrollment
5,058 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Sep 25, 2026, 10:55 PM EDT
Completed Early Phase 1 Interventional

Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO)

NCT00968565
View directory record Official record
Conditions
Heart Defects, Congenital, Respiratory Insufficiency
Interventions
sodium citrate
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
1 Day to 1 Year
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Sep 25, 2026, 10:55 PM EDT
Recruiting No phase listed Observational

Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

NCT03532399
View directory record Official record
Conditions
Drug Effect
Interventions
Bivalirudin
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Sep 25, 2026, 10:55 PM EDT