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ClinicalTrials.gov public records Last synced Oct 17, 2026, 6:19 AM EDT

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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Fear Conditioning Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Expectation of Unpleasant Events in Anxiety Disorders

NCT00055224
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Threat of shock
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
921 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 17, 2026, 6:19 AM EDT
Not listed Not applicable Interventional

Neuroimaging of Pavlovian Fear Conditioning Processes in Patients With Pathological Anxiety

NCT03498599
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Anxiety Disorders, Panic Disorder, Social Phobia, Phobia
Interventions
Novelty facilitated extinction, Standard Extinction
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2018 · Synced Oct 17, 2026, 6:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Fear Conditioning Using Computer-Generated Virtual Reality

NCT00025844
View directory record Official record
Conditions
Anxiety Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
7 Years to 50 Years
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Optimizing Exposure Therapy With Mental Rehearsal

NCT03934385
View directory record Official record
Conditions
Anxiety Disorders, Arachnophobia
Interventions
Mental Rehearsal, Exposure
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2019 · Synced Oct 17, 2026, 6:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebral GABA and Fear Conditioning in PTSD

NCT01800383
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
Isabelle Rosso
Other
Eligibility
20 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 17, 2026, 6:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Functional Neuroanatomy of Emotion Perception, Recognition, Learning, and Memory

NCT00458432
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
20 Years to 40 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Computerized Anxiety Treatment for Suicide

NCT01990131
View directory record Official record
Conditions
Anxiety, Suicide
Interventions
Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 9, 2016 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Effects of Multicomponent Training in Older Adults

NCT06094413
View directory record Official record
Conditions
Sarcopenia
Interventions
Multicomponent Training Intervention
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Scranton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Oct 17, 2026, 6:19 AM EDT
Recruiting Not applicable Interventional

Amygdala-Prefrontal in Fear Extinction

NCT07800455
View directory record Official record
Conditions
Fear Extinction
Interventions
Direct intracranial electrical stimulation, Fear conditioning
Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD

NCT05521074
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Completed No phase listed Observational Results available

Key Dimensions of PTSD and ED

NCT03778307
View directory record Official record
Conditions
Trauma, PTSD, Endothelial Dysfunction
Interventions
Psychophysiological fear conditioning and extinction task, Eyetracking task
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Neuroimaging Memories of Fear and Safety in the Human Brain

NCT04975009
View directory record Official record
Conditions
Fear Anxiety, PTSD
Interventions
Fear conditioning
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 50 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Evaluation of a Brief, Online Intervention for Military Personnel

NCT03579706
View directory record Official record
Conditions
Experimental, Placebo Contol
Interventions
Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Oct 17, 2026, 6:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence

NCT02438969
View directory record Official record
Conditions
Fear, Stress, Alcohol Dependence
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans

NCT06240052
View directory record Official record
Conditions
Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning
Interventions
Conditioning and active avoidance paradigm (CAAP)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Depression and Anxiety Reduction Treatment for Suicide

NCT01941862
View directory record Official record
Conditions
Anxiety, Depression, Suicide
Interventions
Psychoeducation and Cognitive Bias Modification
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Computerized Anxiety Sensitivity Treatment for Opioid Use Disorders

NCT03944850
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Computerized Anxiety Sensitivity Treatment
Behavioral
Lead sponsor
Southeast Louisiana Veterans Health Care System
Federal
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Oct 17, 2026, 6:19 AM EDT
Recruiting Not applicable Interventional

Disrupting Fear-based Memory Consolidation

NCT05560113
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Continuous theta burst stimulation (cTBS), Sham continuous theta burst stimulation (cTBS)
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise and Therapeutic Learning Among Women With PTSD

NCT04113798
View directory record Official record
Conditions
PTSD
Interventions
Day 1 Assessments, Day 2 Fear Learning, Day 3 Fear Extinction, Moderate Intensity Exercise, Low Intensity Exercise, Day 4 Recall of Fear Extinction
Other · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years to 50 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 19, 2020 · Synced Oct 17, 2026, 6:19 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Cannabidiol Effects on Learning and Anxiety

NCT05283382
View directory record Official record
Conditions
Anxiety and Fear
Interventions
Cannabidiol Oral Product, Placebo
Drug · Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Fear and Avoidance in PTSD Patients

NCT04770584
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Fear Conditioning, Avoidance conditioning, Pavlovian fear extinction learning, Willingness to pay to avoid shock
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Early Phase 1 Interventional

Effects of Duloxetine on Fear Conditioning in Posttraumatic Stress Disorder (PTSD)

NCT00763178
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Duloxetine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Oct 17, 2026, 6:19 AM EDT
Completed Phase 2 Interventional Results available

Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder

NCT00383786
View directory record Official record
Conditions
PTSD
Interventions
NK1 Antagoist (GR205171), Psychophysiology (Trauma Script), Psychophysiology (Verbal Threat), Psychophysiology (Fear Conditioning), Psychophysiology (Affective Modulation), Psychophysiology (Heart rate variability), Lumbar Puncture, 24-hour plasma sampling, MRI
Drug · Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Bethesda, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Oct 17, 2026, 6:19 AM EDT
Terminated No phase listed Observational

Social Anxiety Virtual Reality Study

NCT04288180
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
No intervention
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2021 · Synced Oct 17, 2026, 6:19 AM EDT