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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Fear conditioning Clear all
Recruiting Not applicable Interventional

Amygdala-Prefrontal in Fear Extinction

NCT07800455
View directory record Official record
Conditions
Fear Extinction
Interventions
Direct intracranial electrical stimulation, Fear conditioning
Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 3, 2026, 4:54 PM EDT
Not listed Early Phase 1 Interventional

Responsive Neurostimulation for Post-Traumatic Stress Disorder

NCT04152993
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
NeuroPace® RNS® System
Device
Lead sponsor
VA Greater Los Angeles Healthcare System
Federal
Eligibility
25 Years to 60 Years · Male only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 27, 2024 · Synced Sep 3, 2026, 4:54 PM EDT
Withdrawn Not applicable Interventional

Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer

NCT07226102
View directory record Official record
Conditions
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Endometrial Carcinoma, Endometrial Endometrioid Adenocarcinoma, Female Reproductive System Neoplasm, Stage II Ovarian Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8, Stage III Vaginal Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Vaginal Cancer AJCC v8, Stage IV Vulvar Cancer AJCC v8, Triple-Negative Breast Carcinoma
Interventions
Behavioral Intervention, Educational Intervention, Internet-Based Intervention, Interview, Survey Administration, Virtual Technology Intervention
Behavioral · Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
12
States / cities
Arcadia, California • Duarte, California • Irvine, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Overgeneralization of Conditioned Fear as a Pathogenic Marker of Anorexia Nervosa

NCT02148042
View directory record Official record
Conditions
Anorexia, Generalized Anxiety
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Anxiety Sensitivity Treatment for Suicide

NCT01947179
View directory record Official record
Conditions
Anxiety
Interventions
Anxiety Risk Reduction
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Cannabinoid Augmentation of Fear Response in Humans

NCT01665573
View directory record Official record
Conditions
Fear Conditioning
Interventions
PF-04457845, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Effects of Multicomponent Training in Older Adults

NCT06094413
View directory record Official record
Conditions
Sarcopenia
Interventions
Multicomponent Training Intervention
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Scranton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.

NCT01733030
View directory record Official record
Conditions
Post Traumatic Stress Syndrome
Interventions
Seromycin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 55 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Evaluation of a Brief, Online Intervention for Military Personnel

NCT03579706
View directory record Official record
Conditions
Experimental, Placebo Contol
Interventions
Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2020 · Synced Sep 3, 2026, 4:54 PM EDT
Not listed Early Phase 1 Interventional

Cannabidiol Effects on Fear Extinction in Social Phobia

NCT06123702
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
Fear extinction, Cannabidiol Cap/Tab, Placebo
Behavioral · Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence

NCT02438969
View directory record Official record
Conditions
Fear, Stress, Alcohol Dependence
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 3, 2026, 4:54 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

K08 VR Fear Conditioning

NCT07216222
View directory record Official record
Conditions
Anxiety and Fear, PTSD, Veteran
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurobiology of Generalized Fear-Conditioning & Avoidance in Anxiety Disorders

NCT03033056
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Test of fear conditioning
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Effect of tDCS Timing on Safety Memory in PTSD

NCT04152772
View directory record Official record
Conditions
PTSD
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Could Meditation Modulate the Neurobiology of Learning Not to Fear?

NCT01320969
View directory record Official record
Conditions
Healthy Individuals, Highly Stressed
Interventions
Mindfulness-Based Stress Reduction course
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2012 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Results available

Key Dimensions of PTSD and ED

NCT03778307
View directory record Official record
Conditions
Trauma, PTSD, Endothelial Dysfunction
Interventions
Psychophysiological fear conditioning and extinction task, Eyetracking task
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Optimizing Exposure Therapy With Mental Rehearsal

NCT03934385
View directory record Official record
Conditions
Anxiety Disorders, Arachnophobia
Interventions
Mental Rehearsal, Exposure
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)

NCT01477762
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD

NCT05521074
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 3, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans

NCT06240052
View directory record Official record
Conditions
Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning
Interventions
Conditioning and active avoidance paradigm (CAAP)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress, Sex, and the Generalization of Fear

NCT03786952
View directory record Official record
Conditions
Psychological Stress
Interventions
Stress immediately before learning in males, Sham control immediately before learning in males, Stress 30 minutes before learning in males, Sham control 30 minutes before learning in males, Stress immediately before learning in females, Sham control immediately before learning in females, Stress 30 minutes before learning in females, Sham control 30 minutes before learning in females
Behavioral
Lead sponsor
Ohio Northern University
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ada, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 3, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder

NCT00383786
View directory record Official record
Conditions
PTSD
Interventions
NK1 Antagoist (GR205171), Psychophysiology (Trauma Script), Psychophysiology (Verbal Threat), Psychophysiology (Fear Conditioning), Psychophysiology (Affective Modulation), Psychophysiology (Heart rate variability), Lumbar Puncture, 24-hour plasma sampling, MRI
Drug · Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Bethesda, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Sep 3, 2026, 4:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebral GABA and Fear Conditioning in PTSD

NCT01800383
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
Isabelle Rosso
Other
Eligibility
20 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 3, 2026, 4:54 PM EDT
Terminated No phase listed Observational

Social Anxiety Virtual Reality Study

NCT04288180
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
No intervention
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 3, 2026, 4:54 PM EDT