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ClinicalTrials.gov public records Last synced Oct 5, 2026, 6:59 AM EDT

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Showing 25–48 of 90 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Fluoxetine (prozac) Clear all
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

NCT04131829
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Fluoxetine - immediate treatment, Fluoxetine - delayed treatment
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Not applicable Interventional

Care Transition Intervention for Patients With Cancer

NCT04640714
View directory record Official record
Conditions
Advanced Cancer, Home Care, Hospital-Based
Interventions
CONTINUity of care Under Management by Video visits (CONTINUUM-V)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2021 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy

NCT00986310
View directory record Official record
Conditions
Uncontrolled Partial Epilepsy, Ictal Hypoventilation
Interventions
Fluoxetine, Placebo
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Not applicable Interventional Results available

Perioperative Mental Health in Orthopedic Surgery

NCT05697835
View directory record Official record
Conditions
Orthopedic Surgery, Older Adults, Depression, Anxiety
Interventions
Behavioral activation, Medication optimzation, Care as usual
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 4 Interventional

Prozac Treatment of Major Depression: Discontinuation Study

NCT00427128
View directory record Official record
Conditions
Major Depression
Interventions
fluoxetine, placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
627 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2003
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2011 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 2 Interventional

Evaluating the Results of Physician and Parent Decisions to Treat Selective Mutism With Fluoxetine

NCT05378711
View directory record Official record
Conditions
Selective Mutism, Social Anxiety
Interventions
Fluoxetine
Drug
Lead sponsor
Michigan State University
Other
Eligibility
5 Years to 18 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 3 Interventional Results available

A Study in Relapse Prevention of Treatment-Resistant Depression

NCT00958568
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Olanzapine and Fluoxetine combination (OFC), Fluoxetine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
892 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
36
States / cities
Pasadena, California • Sherman Oaks, California • Wildomar, California + 33 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2014 · Synced Oct 5, 2026, 6:59 AM EDT
Withdrawn Phase 4 Interventional

Open Label Trial of Fluoxetine for the Treatment of Depression in Patients With End Stage Renal Disease

NCT00573547
View directory record Official record
Conditions
Depression
Interventions
Fluoxetine
Drug
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 16, 2011 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 3 Interventional

Treatment for Adolescents With Depression Study (TADS)

NCT00006286
View directory record Official record
Conditions
Major Depressive Disorder, Depression
Interventions
Fluoxetine, Psychotherapy
Drug · Behavioral
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
12 Years to 17 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
12
States / cities
Chicago, Illinois • Baltimore, Maryland • Detroit, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2014 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Treatment of Hypochondriasis With CBT and/or SSRI

NCT00339079
View directory record Official record
Conditions
Hypochondriasis
Interventions
Fluoxetine, Cognitive Behavioral Therapy (CBT), Supportive Therapy, Placebo
Drug · Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years and older
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Not applicable Interventional Results available

Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse

NCT00612313
View directory record Official record
Conditions
Depression
Interventions
Fluoxetine, Relapse prevention cognitive behavioral therapy (CBT)
Drug · Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
8 Years to 17 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder

NCT00678574
View directory record Official record
Conditions
Premenstrual Dysphoric Disorder, Premenstrual Syndrome
Interventions
fluoxetine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 27, 2018 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 2 Interventional Results available

Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation

NCT01714310
View directory record Official record
Conditions
Severe Mood Dysregulation
Interventions
lisdexamfetamine, Placebo, fluoxetine
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
7 Years to 17 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bioequivalence Study of Fluoxetine HCL 40 mg Capsules Under Fasting Conditions

NCT00778024
View directory record Official record
Conditions
Healthy
Interventions
fluoxetine HCL 40 mg capsules
Drug
Lead sponsor
Ranbaxy Laboratories Limited
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 15, 2009 · Synced Oct 5, 2026, 6:59 AM EDT
Recruiting Phase 4 Interventional

Identifying and Treating Depression in the Orthopaedic Trauma Population

NCT05976347
View directory record Official record
Conditions
Depression
Interventions
Fluoxetine 20 MG, Duloxetine 30 MG, Observation
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 4 Interventional Results available

Fluoxetine in Pediatric Body Dysmorphic Disorder

NCT00245635
View directory record Official record
Conditions
Body Dysmorphic Disorder
Interventions
Fluoxetine, Placebo
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
Up to 16 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
2
States / cities
The Bronx, New York • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 27, 2018 · Synced Oct 5, 2026, 6:59 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Supplemental Transcranial Magnetic Stimulation (TMS) vs. Standard Medication Monotherapy for Treating Major Depression: An Exploratory Field Study

NCT01944657
View directory record Official record
Conditions
1. Major Depressive Disorder
Interventions
Supplemental TMS, Standard Medication Monotherapy
Device · Drug
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 5, 2026, 6:59 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

National Pregnancy Registry for Psychiatric Medications

NCT01246765
View directory record Official record
Conditions
Pregnant Women, Psychotropic Drugs
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2033
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Fluoxetine in Juvenile Fibromyalgia

NCT00115804
View directory record Official record
Conditions
Juvenile Primary Fibromyalgia Syndrome (JPFS), Fibromyalgia
Interventions
Fluoxetine
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
13 Years to 18 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 5, 2026, 6:59 AM EDT
Terminated Phase 2 Interventional Results available

Fluoxetine for Visual Recovery After Ischemic Stroke

NCT02737930
View directory record Official record
Conditions
Acute Stroke, Visual Field Loss
Interventions
Fluoxetine, Placebo
Drug
Lead sponsor
Bogachan Sahin
Other
Eligibility
18 Years to 85 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 2 Interventional Results available

Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI

NCT02929667
View directory record Official record
Conditions
Epilepsy, SUDEP
Interventions
Fluoxetine, Placebo
Drug
Lead sponsor
Rup Kamal Sainju
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Oct 5, 2026, 6:59 AM EDT
Active, not recruiting Early Phase 1 Interventional

Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)

NCT05634707
View directory record Official record
Conditions
Primary Brain Tumor, Brain Tumor, Recurrent
Interventions
Fluoxetine, Temozolomide
Drug
Lead sponsor
Duke University
Other
Eligibility
24 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
4
States / cities
San Diego, California • Stanford, California • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 4 Interventional

Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)

NCT00006204
View directory record Official record
Conditions
Alcoholism, Alcohol Dependence, Depression
Interventions
naltrexone (Revia), fluoxetine (Prozac)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2007 · Synced Oct 5, 2026, 6:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients

NCT00581009
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Disorder
Interventions
chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans
Other · Drug · Radiation
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2011
U.S. locations
2
States / cities
Irvine, California • La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 5, 2026, 6:59 AM EDT