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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Frail Clear all
Active, not recruiting Phase 2 Interventional Results available

Isa-Pom-Dex in Elderly/Frail Subjects With RRMM

NCT05911321
View directory record Official record
Conditions
Multiple Myeloma, Relapse, Refractory, Aging, Co-morbidity
Interventions
Isatuximab, Pomalidomide, Dexamethasone
Drug
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 3 Interventional

Evaluation of an Oral Nutritional Supplement Containing AN777

NCT01191125
View directory record Official record
Conditions
Malnutrition, Sarcopenia
Interventions
medical food with AN777, oral nutritional formula
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
65 Years to 90 Years
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
8
States / cities
Birmington, Alabama • Santa Rosa, California • Addison, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2013 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery

NCT03299101
View directory record Official record
Conditions
Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery, Frailty
Interventions
Prehabilitation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 9, 2026, 7:59 AM EDT
Active, not recruiting Not applicable Interventional

The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail

NCT07167277
View directory record Official record
Conditions
Pre-frail, Pre-Frail Older Adults, Cognition, Physical Function, Dietary Intake Assessment, MRI
Interventions
Whey Protein, Placebo
Dietary Supplement
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 9, 2026, 7:59 AM EDT
Completed No phase listed Observational

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

NCT02270502
View directory record Official record
Conditions
Critical Illness, Sarcopenia, Muscle Wasting
Interventions
Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
Device · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 9, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Improve Outcomes for Older Allogeneic Transplant Recipients

NCT05612789
View directory record Official record
Conditions
Allogeneic Transplantation
Interventions
Exercise Program (Cohort A Prehab), Exercise Program (Cohort B Rehab)
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
60 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 9, 2026, 7:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Geriatric Anorexia Study

NCT04858932
View directory record Official record
Conditions
Healthy
Interventions
Continuous Glucose Monitor, Wrist Actigraphy Device, Food Weight Scale, Smart Body Weight Scale
Device
Lead sponsor
Boston University
Other
Eligibility
65 Years to 85 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional

AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program

NCT06079762
View directory record Official record
Conditions
Frailty, Aging, Frailty Syndrome, Frail Elderly Syndrome
Interventions
AGE SELF CARE group visit program
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years to 110 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 9, 2026, 7:59 AM EDT
Recruiting Phase 2 Interventional

Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

NCT05145400
View directory record Official record
Conditions
Multiple Myeloma, Cancer
Interventions
Isatuximab, Lenalidomide, Dexamethasone
Drug
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2033
U.S. locations
5
States / cities
Chapel Hill, North Carolina • Charlotte, North Carolina • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Comparison of Subacute and Hospital Based Rehabilitation Care

NCT00038363
View directory record Official record
Conditions
Aging
Interventions
Rehabilitation, Subacute care
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 9, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Characterizing the Impact of Presbyphonia on Social Interaction

NCT06441136
View directory record Official record
Conditions
Presbyphonia
Interventions
PhoRTE Program, University of California Los Angeles (UCLA) Loneliness Scale, Social Disconnectedness Scale, Patient Health Questionnaire 9, Aging Voice Index, The Edmonton Frail Scale, Vocal Effort Scale, Montreal Cognitive Assessment, Voice Handicap Index-10, Voice Problem Impact Scales, Cough Severity Index, Laryngoscopy, Acoustic, perceptual, and aerodynamic assessments
Other · Procedure
Lead sponsor
Matthew R. Hoffman
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 9, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Prehabilitation for Kidney Transplant Candidates

NCT06886256
View directory record Official record
Conditions
Kidney Transplantation, Frailty, Chronic Kidney Insufficiency
Interventions
Polar H10 Heart Rate Monitor, Empatica EmbracePlus, Apple Watch Ultra 2
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
55 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Exercise Poles on Older Adults During Exercise Walking

NCT00037167
View directory record Official record
Conditions
Movement Disorders, Aging
Interventions
Exercise poles
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
65 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 8, 2009 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

The Helping Older People Engage Project: Improving Social Well-Being in Later Life

NCT03343483
View directory record Official record
Conditions
Loneliness, Quality of Life
Interventions
Volunteering, Life Review
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer

NCT00296023
View directory record Official record
Conditions
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
Interventions
anti-thymocyte globulin, filgrastim, therapeutic allogeneic lymphocytes, busulfan, fludarabine phosphate, methotrexate, tacrolimus, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
Biological · Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2008
U.S. locations
2
States / cities
Berkeley, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2012 · Synced Sep 9, 2026, 7:59 AM EDT
Not listed Phase 4 Interventional

HOPE - A Study to Evaluate the Effect of a Prehabilitation Program on GI Cancer Patients Planning to Undergo Surgery

NCT03642093
View directory record Official record
Conditions
Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
Interventions
Nutritional Intervention, Physical Activity Intervention
Combination Product · Behavioral
Lead sponsor
Siobhan Trotter
Other
Eligibility
25 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Sep 9, 2026, 7:59 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

NCT02338947
View directory record Official record
Conditions
Frail Elderly, Coronary Artery Disease
Interventions
Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
Other
Lead sponsor
University of Sao Paulo General Hospital
Other
Eligibility
60 Years and older
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Promoting Seniors' Health With Home Care Aides

NCT03301116
View directory record Official record
Conditions
Muscle Weakness
Interventions
Healthy Moves for Aging Well (Healthy Moves), Active Mind for Aging Well (Active Mind)
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years to 110 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Testosterone Therapy After Hip Fracture in Elderly Women

NCT00280267
View directory record Official record
Conditions
Hip Fracture, Testosterone Deficiency, Muscle Weakness
Interventions
Testosterone gel
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 3, 2009 · Synced Sep 9, 2026, 7:59 AM EDT
Not listed Phase 3 Interventional

MD.2 Medication Dispenser Medication Adherence Study

NCT00560001
View directory record Official record
Conditions
Frail Elderly, Medication Errors
Interventions
MD.2 Medication Dispenser
Behavioral
Lead sponsor
Interactive Medical Developments
Industry
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 7, 2009 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Effects of Functional Incidental Training in VA NHCU Residents

NCT00013507
View directory record Official record
Conditions
Aging
Interventions
Falls
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Longitudinal Outcome in a Veterans Geriatric Multifactorial Falls Assessment Clinic

NCT02356211
View directory record Official record
Conditions
Aging
Interventions
Multifactorial Falls Assessment
Other
Lead sponsor
Powers, James S., M.D.
Individual
Eligibility
65 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Phase 2 Interventional Results available

Bevacizumab Plus Capecitabine (Xeloda) in Patients With Untreated Metastatic Colorectal Cancer

NCT00203411
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Capecitabine (Xeloda), Bevacizumab
Drug
Lead sponsor
Translational Oncology Research International
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
12
States / cities
Alhambra, California • Bakersfield, California • Fullerton, California + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2017 · Synced Sep 9, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Piloting Prehabilitation Before Abdominal Surgery

NCT03040336
View directory record Official record
Conditions
Frailty
Interventions
Prehabilitation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 9, 2026, 7:59 AM EDT