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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Frailty Assessment Clear all
Terminated No phase listed Observational

Frailty Study of Older Adults Getting Chemotherapy and Radiation Therapy

NCT01808833
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
70 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2014 · Synced Sep 17, 2026, 3:57 PM EDT
Completed Phase 3 Interventional Results available

PREPARE (A5361s) Ancillary Study of REPRIEVE (A5332)

NCT03070223
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Pitavastatin, Placebos
Drug
Lead sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Network
Eligibility
40 Years to 75 Years
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
30
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 22 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2024 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Systems Investigation of Vaccine Responses in Aging and Frailty

NCT05291676
View directory record Official record
Conditions
Influenza
Interventions
Fluzone, Fluad
Biological
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 17, 2026, 3:57 PM EDT
Not listed Early Phase 1 Interventional

Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty

NCT04770350
View directory record Official record
Conditions
Frailty, Aging
Interventions
Focused Ultrasound
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
45 Years to 95 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 17, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Effects of Tai Chi on Frailty in Elderly Adults

NCT01126723
View directory record Official record
Conditions
Frailty
Interventions
Tai Chi, Education-Control
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
70 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting No phase listed Observational

Functional Assessment in Liver Transplantation

NCT03228290
View directory record Official record
Conditions
End Stage Liver Disease
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2030
U.S. locations
12
States / cities
Little Rock, Arkansas • Loma Linda, California • San Francisco, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Frailty Prevention Program to Prevent Frailty Among Older African Americans

NCT03585972
View directory record Official record
Conditions
Frail Elderly Syndrome
Interventions
Frailty Prevention Program
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
55 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2019 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting Not applicable Interventional

A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings

NCT06404970
View directory record Official record
Conditions
Functional Impairment, Frailty
Interventions
Screening intervention, Standard bundle of implementation strategies, Enhanced bundle of implementation strategies
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting Not applicable Interventional

Characterizing the Impact of Presbyphonia on Social Interaction

NCT06441136
View directory record Official record
Conditions
Presbyphonia
Interventions
PhoRTE Program, University of California Los Angeles (UCLA) Loneliness Scale, Social Disconnectedness Scale, Patient Health Questionnaire 9, Aging Voice Index, The Edmonton Frail Scale, Vocal Effort Scale, Montreal Cognitive Assessment, Voice Handicap Index-10, Voice Problem Impact Scales, Cough Severity Index, Laryngoscopy, Acoustic, perceptual, and aerodynamic assessments
Other · Procedure
Lead sponsor
Matthew R. Hoffman
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 17, 2026, 3:57 PM EDT
Completed No phase listed Observational

Measure of Frailty in Perioperative Setting

NCT02838511
View directory record Official record
Conditions
Frailty
Interventions
Modified Frailty Index (MFI), Hopkins Frailty Score (HFS)
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
1,190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 17, 2026, 3:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Physical Activity Monitoring in Frailty and Falling

NCT01880229
View directory record Official record
Conditions
Fraility, Risk of Falling
Interventions
Not listed
Lead sponsor
BioSensics
Industry
Eligibility
65 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
2
States / cities
Tucson, Arizona • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting No phase listed Observational

PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

NCT06089083
View directory record Official record
Conditions
Malignant Female Reproductive System Neoplasm, Gynecologic Cancer, Gynecologic Neoplasm
Interventions
Physical function assessment, Self-reported Assessments and Questionnaires, Surgery (Standard of Care, Non-Interventional)
Other · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
2
States / cities
San Francisco, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Virtual Visits to Optimize Research Trial Offerings to HF Patients

NCT04064541
View directory record Official record
Conditions
Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction
Interventions
Virtual Visit
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 16, 2020 · Synced Sep 17, 2026, 3:57 PM EDT
Active, not recruiting Not applicable Interventional

PAtient-centered mUltidiSciplinary Care for vEterans Undergoing Surgery (PAUSE)

NCT05037292
View directory record Official record
Conditions
Frailty
Interventions
PAUSE Intervention
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
35,015 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Palo Alto, California • Nashville, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting Not applicable Interventional

Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

NCT07029243
View directory record Official record
Conditions
Cirrhosis, Frailty, Sarcopenia
Interventions
HEAL-ME digital app, Creatine supplementation, Whey protein supplementation, Placebo
Behavioral · Dietary Supplement
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Post-ICU Palliative Care Intervention (PIPCI) Trial

NCT03456323
View directory record Official record
Conditions
Critical Illness, Frailty, Palliative Care
Interventions
Palliative Care Consultation, Usual Care
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
50 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

NCT06890676
View directory record Official record
Conditions
Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections, Oral Infections, Periapical Infections, Pneumonia, Diabetes
Interventions
Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous, Periodontal Therapy, Periodontal Maintenance Procedure, Application of Caries Arresting Medicament, Oral Hygiene Assistance, Referral for Treatment of Acute Oral Infection
Other · Procedure
Lead sponsor
Missouri Department of Health and Senior Services
Other
Eligibility
60 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Jefferson City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Sep 17, 2026, 3:57 PM EDT
Terminated No phase listed Observational

Functional Assessment in Liver Transplantation

NCT03870568
View directory record Official record
Conditions
Cirrhosis, End Stage Liver Disease
Interventions
Not listed
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
411 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Completed No phase listed Observational

Aging and Frailty Study

NCT05268991
View directory record Official record
Conditions
Effects of Chemotherapy, Aging, Frailty
Interventions
Geriatric Assessments and Frailty Indices
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 17, 2026, 3:57 PM EDT
Not listed Not applicable Interventional

The Effects of Frailty on Chronic Kidney Disease

NCT02775305
View directory record Official record
Conditions
Sarcopenia, Chronic Kidney Disease
Interventions
Frail
Behavioral
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Sep 17, 2026, 3:57 PM EDT
Withdrawn No phase listed Observational

Mobility and Physical Activity in Adolescent and Young Adult Cancer Patients or Survivors at Risk for Cardiovascular Morbidity and Frailty, The MOBILE AYA Study

NCT05169151
View directory record Official record
Conditions
Central Nervous System Neoplasm, Hodgkin Lymphoma, Malignant Solid Neoplasm, Non-Hodgkin Lymphoma, Sarcoma
Interventions
Smartphone Application
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
15 Years to 39 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Sep 17, 2026, 3:57 PM EDT
Recruiting No phase listed Observational

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

NCT04717869
View directory record Official record
Conditions
Frailty, Sarcopenia
Interventions
Ultrasound, Biomarker Analysis, Frailty Index
Diagnostic Test · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Active, not recruiting No phase listed Observational

The Effect of the COVID-19 Pandemic on Frailty in Liver Transplant Candidates

NCT05935800
View directory record Official record
Conditions
Frailty, Sarcopenia, COVID-19
Interventions
COVID Patients who Underwent pre-transplant frailty assessment (PFA) at MDMC
Behavioral
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 17, 2026, 3:57 PM EDT
Completed No phase listed Observational

Frailty Index and Geriatric Assessment in Predicting Toxicity to Front-Line Chemotherapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer

NCT01026467
View directory record Official record
Conditions
Recurrent Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Interventions
cisplatin, carboplatin, questionnaire administration
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Not listed
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Syracuse, New York • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 17, 2026, 3:57 PM EDT