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ClinicalTrials.gov public records Last synced Oct 22, 2026, 8:05 PM EDT

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Showing 529–552 of 1,228 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional Results available

Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

NCT03070392
View directory record Official record
Conditions
Uveal Melanoma
Interventions
IMCgp100, Dacarbazine, Ipilimumab, Pembrolizumab
Biological · Drug
Lead sponsor
Immunocore Ltd
Industry
Eligibility
18 Years to 99 Years
Enrollment
378 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
23
States / cities
Los Angeles, California • Palo Alto, California • San Francisco, California + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated No phase listed Observational Results available

Lower Extremity Fixation In Neuropathic Patients Study

NCT04607044
View directory record Official record
Conditions
Neuropathy, Charcot; Disease (Etiology)
Interventions
SALVATION™ EXTERNAL FIXATION
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Trinity, Florida • West Chester, Pennsylvania • Sparta, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Not applicable Interventional Results available

Evaluation of 3D Machine-vision Image Guided Surgery Spine Navigation

NCT03968965
View directory record Official record
Conditions
Spinal Stenosis, Lumbar Region, Spondylolisthesis
Interventions
3D MvIGS Spine Navigation, 2D Fluoroscopy
Device · Other
Lead sponsor
7D Surgical Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Phase 2 Interventional

Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

NCT06995677
View directory record Official record
Conditions
Low-grade NMIBC, FGFR Gene Amplification, FGFR Gene Alterations, FGFR3 Gene Alteration, FGFR3 Gene Mutation, FGFR3 Gene Fusions
Interventions
TYRA-300 60mg, TYRA-300 50mg, TYRA-300 Dose 70 mg
Drug
Lead sponsor
Tyra Biosciences, Inc
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
36
States / cities
Homewood, Alabama • Little Rock, Arkansas • Murrieta, California + 31 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Withdrawn Not applicable Interventional

Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease

NCT01616719
View directory record Official record
Conditions
Cervical Spondylosis, Cervical Radiculopathy, Cervical Degenerative Disc Disease
Interventions
DTRAX Graft
Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
35 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 22, 2026, 8:05 PM EDT
Enrolling by invitation Not applicable Interventional

Fusion Guided Focal Laser Ablation of Prostate Cancer

NCT02759744
View directory record Official record
Conditions
Prostate Cancer, Prostate Neoplasms
Interventions
ultrasound image-guided ablation device
Device
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 100 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2032
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Postoperative subQ Pain Control for Spinal Fusion Surgery

NCT03476811
View directory record Official record
Conditions
Spine Fusion, Surgery, Pain, Postoperative
Interventions
0.25% Marcaine at 2ml/hr and pain medications, Placement of OnQ Drug pump
Drug · Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 3 Interventional

A Study to Assess the Efficacy and Safety of Two Dosing Regimens of Alefacept in Subjects Weighing Between 100kg and 150kg With Moderate to Severe Chronic Plaque Psoriasis

NCT00674063
View directory record Official record
Conditions
Chronic Plaque Psoriasis
Interventions
alefacept
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
11
States / cities
Hot Springs, Arkansas • Fridley, Minnesota • Omaha, Nebraska + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2014 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 2 Interventional Results available

T-20 Plus a Selected Anti-HIV Treatment in HIV-Infected Children and Adolescents

NCT00022763
View directory record Official record
Conditions
HIV Infections
Interventions
Enfuvirtide
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
3 Years to 16 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2001
U.S. locations
7
States / cities
Los Angeles, California • Gainesville, Florida • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2016 · Synced Oct 22, 2026, 8:05 PM EDT
Enrolling by invitation Not applicable Interventional

Anterior Vertebral Body Tethering (AVBT) Using Zimmer Biomet Tether System or Dynesys System Components to Treat Pediatric Scoliosis

NCT03506334
View directory record Official record
Conditions
Scoliosis
Interventions
AVBT using Dynesys System Components, Spine fusion
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
10 Years to 16 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Recruiting Not applicable Interventional

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

NCT07218133
View directory record Official record
Conditions
Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care, Spine Disease, Neurologic Deficits, Neurological Disorder, Inflammation, Spine Condition, Spinal (Fusion) Surgery, Cytokine Levels, Spine Fusion
Interventions
Auricular vagus nerve stimulation, Sham Auricular Vagus nerve Stimulation
Device
Lead sponsor
Alexander T. Yahanda
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 2 Interventional Results available

Combination Immunotherapy in Biochemically Recurrent Prostate Cancer

NCT03315871
View directory record Official record
Conditions
Prostate Cancer
Interventions
Antigen direct immunotherapy: PROSTVAC-V, Antigen direct immunotherapy: PROSTVAC-F, MSB0011359C (M7824), Antigen direct immunotherapy: CV301, CT scan of chest, CT scan of abdomen/pelvis, MRI, PSMA, Bone scan
Biological · Drug · Diagnostic Test
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Active, not recruiting Phase 3 Interventional

FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)

NCT04768972
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
ION363, Placebo
Drug
Lead sponsor
Ionis Pharmaceuticals, Inc.
Industry
Eligibility
10 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
8
States / cities
La Jolla, California • Palo Alto, California • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Phase 1 Interventional

Study of ONO-7579 in Patients With Advanced Solid Tumors/ NTRK Gene Fusion Positive Advanced Solid Tumors

NCT03182257
View directory record Official record
Conditions
Solid Tumor
Interventions
ONO-7579
Drug
Lead sponsor
Ono Pharmaceutical Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
4
States / cities
Lake Success, New York • New York, New York • Greenville, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2019 · Synced Oct 22, 2026, 8:05 PM EDT
Terminated Not applicable Interventional Results available

Electromagnetic Tracking and Optical Imaging With ICG for Hepatic Biopsies

NCT04258566
View directory record Official record
Conditions
Hepatocellular Carcinoma
Interventions
Optical Molecular Imaging (OMI), Indocyanine Green (ICG), Electromagnetic Tracking
Device · Radiation
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 100 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 1 Interventional

A Study of EXG102-031 in Patients With wAMD (Everest)

NCT05903794
View directory record Official record
Conditions
Neovascular (Wet) Age-related Macular Degeneration (nAMD)
Interventions
EXG102-031
Biological
Lead sponsor
Exegenesis Bio
Industry
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Reno, Nevada • Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Enrolling by invitation Phase 2 Interventional

The Effect of Osteoporotic Medications on Vertebral Bone Quality Score

NCT07587775
View directory record Official record
Conditions
Lumbar Degenerative Disease
Interventions
Abaloparatide
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 22, 2026, 8:05 PM EDT
Completed No phase listed Observational

Lung Regeneration After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis

NCT03539770
View directory record Official record
Conditions
Scoliosis Idiopathic Adolescent
Interventions
Posterior spinal fusion
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 21 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 24, 2018 · Synced Oct 22, 2026, 8:05 PM EDT
Not yet recruiting Phase 4 Interventional

Oral Versus Intravenous Acetaminophen in Lumbar Spine Surgery

NCT07203079
View directory record Official record
Conditions
Postoperative Pain
Interventions
Acetaminophen Oral Tablet, placebo oral tablet, Acetaminophen infusion, Placebo infusion
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 1Phase 2 Interventional Results available

DT388IL3 Fusion Protein in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes

NCT00397579
View directory record Official record
Conditions
Leukemia, Myelodysplastic Syndromes, Blastic Plasmacytoid Dendritic Cell Neoplasm
Interventions
DT388IL3
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 1 Interventional

Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency

NCT03815396
View directory record Official record
Conditions
Alpha-1 Antitrypsin Deficiency, AATD
Interventions
INBRX-101/rhAAT-Fc
Drug
Lead sponsor
Inhibrx Biosciences, Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
5
States / cities
Sacramento, California • Gainesville, Florida • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 22, 2026, 8:05 PM EDT
Not listed Phase 2 Interventional

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

NCT04294004
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Fusion
Interventions
TGplPTH1-34 in fibrin, Autologous Bone Graft
Combination Product · Other
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
25 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
15
States / cities
La Jolla, California • Boulder, Colorado • Washington D.C., District of Columbia + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2023 · Synced Oct 22, 2026, 8:05 PM EDT
Completed No phase listed Observational

Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials

NCT00596609
View directory record Official record
Conditions
Trauma, Nervous System
Interventions
Intrathecal Morphine
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 18 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 16, 2009 · Synced Oct 22, 2026, 8:05 PM EDT
Completed Phase 2 Interventional

GW873140 to Treat HIV-1 Infected Adults

NCT00076284
View directory record Official record
Conditions
HIV Infections
Interventions
GW873140
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 22, 2026, 8:05 PM EDT