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ClinicalTrials.gov public records Last synced Nov 7, 2026, 12:28 AM EST

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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: General anesthesia and opioids Clear all

Conditions: Colon Cancer
Interventions: Regional anesthesia and analgesia, general anesthesia followed by opioid analgesia; Procedure · Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Joint Disease, Pain, Acute, Pain, Chronic
Interventions: Cymbalta, Placebo; Drug · Other
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 25 Years to 75 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Anesthesia, Tooth Extraction
Interventions: Midazolam Hydrochloride, Fentanyl, Ketamine, Propofol injection, Nitrous oxide; Drug
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 16 Years and older
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Craniotomy Surgery
Interventions: Liposomal bupivacaine, Bupivacaine Injection, Saline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pain Management, Opioid Use, Prostate Cancer
Interventions: Oxycodone, Acetaminophen, Ketamine, Ketorolac; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 40 Years to 75 Years · Male only
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Postoperative Delirium
Interventions: Alpha Optimization, Emergence from anesthesia with Dexmedetomidine; Procedure · Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 60 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: New York, New York

Conditions: Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Interventions: Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine, adductor canal nerve block, ropivacaine and dexamethasone, Propofol, Fentanyl; Drug · Procedure
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 14 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Brain Activity Related to Opioid Administration, Brain Activity Related to Drug Liking
Interventions: Observational study in patients receiving fentanyl for surgery; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression, Post-traumatic Stress Disorder (PTSD)
Interventions: Ketamine, standard general anesthesia; Drug
Lead sponsor: Texas Tech University Health Sciences Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Lubbock, Texas

Conditions: Supracondylar Fractures
Interventions: Fentanyl, Ropivacaine; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 2 Years to 17 Years
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Breast Cancer
Interventions: Group 1, Group 2, Group 3; Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain, Anesthesia, Cancer
Interventions: Bupivacaine + Fentanyl, Bupivacaine; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Pain, Postoperative
Interventions: Inter-semispinalis Plane Block, Opioids; Procedure · Drug
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation, Fracture Fixation, Internal, Fracture Forearm, Fracture Distal Radius
Interventions: Lidocaine Infusion, Standard of Care (SOC); Drug · Other
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 3 Years to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Opioid Use
Interventions: Acetaminophen, Fentanyl, Propofol; Drug
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 56 Years · Female only
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions: Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 65 Years and older
Enrollment: 218 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cleft Palate Children
Interventions: Ultrasound-guided bilateral suprazygomatic maxillary nerve block, Local anesthetic infiltration of the palate; Procedure
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 9 Months to 2 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Postoperative Nausea and Vomiting
Interventions: Automated recommendation at the start of the case, Automated notification at the start of surgery, Preoperative recommendations: by email, Automated notification at the end of surgery, Anesthesia Information Management System (AIMS), Perioperative Data Warehouse (PDW), General anesthesia, Elective surgery, Propofol, Sevoflurane, Isoflurane, Desflurane, Scopolamine, Droperidol, Haloperidol, Dexamethasone, Promethazine, Meclizine, Aprepitant, Metoclopramide, Fentanyl, Sufentanil, Alfentanil, Remifentanil, Morphine, Meperidine, Hydromorphone, Methadone, Oxycodone, Oxymorphone, Hydrocodone, Ketamine, Ondansetron, Granisetron, Dolasetron mesylate, Palonosetron, Tropisetron, Ramosetron; Procedure · Device · Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 27,034 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Breast Neoplasms
Interventions: General anesthesia and opioids, Regional analgesia and propofol; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 85 Years · Female only
Enrollment: 2,108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2019
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Chronic Post-Surgical Pain
Interventions: Computer-Assisted Preoperative CBT Intervention (PAINTrainer); Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years and older
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 4
States / cities: Philadelphia, Pennsylvania • Radnor, Pennsylvania

Conditions: Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis, Atelectasis, Bronchospasm
Interventions: Neuromuscular Blocking Agents, Anesthetic Adjuncts; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
Interventions: Erector Spinae Plane Block, Subcutaneous Anesthesia; Procedure
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Respiratory Depression
Interventions: Expiron respirator; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Pancreatic Cancer
Interventions: Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/ml, Propofol+ Rocuronium+ Fentanyl + Inhalational, Open Pancreaticoduodenectomy; Drug · Procedure
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 3
States / cities: Basking Ridge, New Jersey • Commack, New York • New York, New York

Search by objective public record fields.

Regional Anesthesia in Colon Rectal Surgery

Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Cranial Blocks for Postoperative Anesthesia

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

Effects of Anesthetic Technique on NK Cells

Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements

Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcomes

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Regional Anesthesia and Breast Cancer Recurrence

Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

Avoiding Neuromuscular Blockers to Reduce Complications

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

Detection of Postoperative Respiratory Depression in High Risk Patients Utilizing Minute Ventilation Monitoring

Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection