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Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: HIV and substance use prevention Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention

NCT03855410
View directory record Official record
Conditions
Tobacco Use, Drug Use, Adolescent Behavior, Alcohol Use, Sexual Risk Behavior
Interventions
S4E, Attention-Matched Control Group
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
13 Years to 21 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Ann Arbor, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention and Risk: Treatment With a New Emphasis on Relationships

NCT03396367
View directory record Official record
Conditions
Adherence, Medication, Risk Reduction, Drug Use, Sex, Anal, HIV/AIDS
Interventions
PARTNER, Education Intervention
Behavioral
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency Department

NCT01113190
View directory record Official record
Conditions
Drug Abuse
Interventions
Computer-delivered Brief Intervention (CBI), Intervener-delivered Brief Intervention (IBI), Adapted Motivational Enhancement Therapy (AMET), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
878 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 6, 2016 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

HIV Prevention Among Vulnerable Male Youth

NCT01771237
View directory record Official record
Conditions
Homosexuality, Male, HIV, Substance-related Disorders, Sexual Dysfunctions, Psychological
Interventions
MyPeeps Manualized Group Intervention, Standard Sexual Health Education
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
16 Years to 20 Years · Male only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional

The Trans-Led Care Study

NCT06880705
View directory record Official record
Conditions
Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol), Human Immunodeficiency Virus (HIV)
Interventions
The TLC Program
Behavioral
Lead sponsor
Illinois Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

HIV/STD Risk and PrEP Implementation Messaging Among Gay, Bisexual, and Other Men Who Have Sex With Men

NCT06183502
View directory record Official record
Conditions
Sexually Transmitted Infections, Gay, Pre Exposure Prophylaxis
Interventions
Quantitative survey, HIV and STI testing, Qualitative Assessment
Behavioral · Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Male only
Enrollment
675 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
3
States / cities
San Diego, California • Atlanta, Georgia • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional

Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients

NCT01671501
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome, Alcoholism, Alcoholic Intoxication, Substance-Related Disorders
Interventions
Motivational Interviewing, Email Feedback, Usual Care
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
614 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

NCT06501781
View directory record Official record
Conditions
HIV Infections, Substance Use
Interventions
Peer Activate-LAI, Standard of Care HIV treatment or prevention with LAI-PrEP/ART
Behavioral · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 26, 2026, 4:40 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking

NCT07264582
View directory record Official record
Conditions
HIV Testing, STI, HCV, Overdose, Drug
Interventions
Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

HIV Prevention Peer Navigation for Justice Involved Women

NCT04680390
View directory record Official record
Conditions
HIV Infections, Stigma, Social
Interventions
Standard of care engagement practices, Peer Navigators Addressing INtersectional Stigma to Improve HIV Prevention Among Criminal-Justice Involved Women
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 49 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

American Indian and Alaska Native Men Who Have Sex With Men HIV & Substance Abuse Research

NCT03049904
View directory record Official record
Conditions
HIV, Substance Use
Interventions
Vr2L 2Spirit
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Male only
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 29, 2018 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Engaging Seronegative Youth to Optimize HIV Prevention Continuum

NCT03134833
View directory record Official record
Conditions
HIV, Mental Health, Substance Use, STI
Interventions
Automated Messaging & Monitoring, Peer Support, Coaching
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 24 Years
Enrollment
1,478 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 4, 2022 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Phase 3 Interventional Results available

Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps)

NCT03512418
View directory record Official record
Conditions
HIV Infections, Substance Use Disorders
Interventions
PrEPsteps, Digital pill, Truvada
Behavioral · Device · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boylston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional

Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV

NCT05434741
View directory record Official record
Conditions
Aging, HIV
Interventions
Weekly Group Skills, One-time Trifold Brochure titled "HIV: 50 Years or Older"
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Sep 26, 2026, 4:40 AM EDT
Active, not recruiting Not applicable Interventional

Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs

NCT05192434
View directory record Official record
Conditions
HIV Infections, Opioid Use, Trauma, Psychological
Interventions
Expressive Writing, Contingency Management
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older · Female only
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

NCT06477588
View directory record Official record
Conditions
HIV, Contingency Management, Justice Involved Populations, Status Neutral Interventions, Mental Health, Substance Use
Interventions
Health Navigation, Health Navigation, Employment Navigation plus Contingency Management Intervention
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional

Addressing Psychosocial Comorbidities in HIV Treatment and Prevention

NCT02696681
View directory record Official record
Conditions
Human Immunodeficiency Virus, Depression, Mental Health
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional

TechMPower: Advancing HIV/SUD Care and Service Delivery for People in Re-entry

NCT07088770
View directory record Official record
Conditions
HIV (Human Immunodeficiency Virus), Substance Abuse Disorder
Interventions
Community Coalition CLS Workgroup/Network of Providers, Tech-mediated Training and Service Delivery, Multidisciplinary Implementation Team with Champion, Tech-mediated Peer Navigation Enhanced Case management (NCM)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kingston, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional

Community Supported Risk Reduction for Syringe Exchange Participants

NCT02654366
View directory record Official record
Conditions
Substance Use Disorders, Risk Reduction
Interventions
Risk Reduction Group
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 19, 2020 · Synced Sep 26, 2026, 4:40 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Long-acting Biomedical HIV Prevention in Transgender Women

NCT03856580
View directory record Official record
Conditions
HIV Prevention, Transgender Women
Interventions
Alternative long-acting PrEP injection strategies, mHealth adherence app
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 100 Years · Male only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Sep 26, 2026, 4:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

NCT01612169
View directory record Official record
Conditions
HIV, AIDS, Substance Abuse, Inpatient
Interventions
Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
801 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
12
States / cities
Birmingham, Alabama • Torrance, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional

Pre-exposure Prophylaxis (PrEP) Adherence Intervention for Women with Substance Use Disorders

NCT06158607
View directory record Official record
Conditions
Substance Use
Interventions
Addiction Clinic-Based PrEP Adherence Intervention for Women with Substance Use Disorders, Standard of care treatment
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 29, 2024 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional

RESTORE Study R61 Phase: Recovery and Engagement for Stimulant Users on Re-entry

NCT07136363
View directory record Official record
Conditions
HIV, Stimulant Use Disorder, Justice Involved Populations, HIV Prevention
Interventions
DynamiCare, Patient Navigation (PN)
Device · Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 26, 2026, 4:40 AM EDT
Recruiting Not applicable Interventional

PrEP Readiness Interventions for Sustained Motivation (PRISM)

NCT06637436
View directory record Official record
Conditions
HIV, Methamphetamine Disorders
Interventions
Motivational Interviewing (MI), Contingency Management (CM)
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 26, 2026, 4:40 AM EDT