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ClinicalTrials.gov public records Last synced Nov 4, 2026, 7:56 AM EST

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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: High level nicotine cigarette Clear all

Conditions: Cigarette Smoking, Veterans
Interventions: Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling, Healthy Changes Counseling; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Alcohol Dependence, Nicotine Dependence
Interventions: Low-Dose Topiramate, Placebo, High-Dose Topiramate; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 4
States / cities: La Jolla, California • Houston, Texas • Charlottesville, Virginia + 1 more

Conditions: Nicotine Dependence
Interventions: Nicotine, Progesterone; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2016
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Smoking Cessation
Interventions: Stepped-Care, Control; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Walnut Creek, California

Conditions: Tobacco Smoking Behavior
Interventions: Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Smoking, Nicotine Addiction, Surgery
Interventions: ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Vaping
Interventions: YES-CAN! program; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 9 Years and older
Enrollment: 1,166 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Nicotine Dependence
Interventions: Varenicline, Bupropion, Nicotine patches, Nicotine Inhaler; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 702 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 4
States / cities: Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more

Conditions: Smoking
Interventions: Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence
Interventions: Nicotine, Experimental Flavor, Menthol Flavor; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Not listed
Lead sponsor: National Institute on Minority Health and Health Disparities (NIMHD); NIH
Eligibility: 21 Years to 120 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: THC, Cannabis, Cannabis Use, Cannabis Smoking, Tobacco Use, Vaping
Interventions: Cannabis, Nicotine, Pax Loose Leaf Vaporizer, Placebo Marijuana; Drug · Device · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: E-cigarette Use
Interventions: ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Electronic Cigarette Use
Interventions: Low strength nicotine e-liquid, High strength nicotine e-liquid; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Modified Natural American Spirit-Tan or Green cigarettes injected with labeled NNK; Combination Product
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Nicotine Use Disorder
Interventions: Nicotine, Flavor; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Vaping Behaviors
Interventions: Health Impacts of E-cigarettes, Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping, The Villainous Vape; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 12 Years to 17 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Healthy Adult Participants
Interventions: 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches, cigarette or e-cigarette; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine, E-liquid Flavors
Interventions: Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL, Nicotine 24 mg/mL, 'Menthol' flavor, 'Menthol/Mint' flavor, 'Green Apple' flavor, 'Watermelon' flavor, 'Unflavored'; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Lung Carcinoma
Interventions: Nicotine Replacement; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 50 Years to 80 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking, Cannabis
Interventions: cannabis; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 3
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking
Interventions: High-ventilated cigarette alone, Low-ventilated cigarette alone, High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price, Low- and high-ventilated cigarette with high-ventilated cigarettes increasing in price, Usual, high- and low-ventilated cigarette with usual cigarettes increasing in price.; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Cigarette Smoking, Nicotine Dependence, Smoking Cessation
Interventions: High Nicotine Dose, Low Nicotine Dose; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment

New Treatment for Alcohol and Nicotine Dependence

Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects

Interventions for Smoking Among Persons in Recovery

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

The END Perioperative Smoking Pilot Study

Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping

Concurrent Bupropion / Varenicline for Smoking Cessation

Palatability of Experimental Cigarettes - Study 2

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

Using Smartwatches to Monitor Smoking in Real-life Situations

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Metabolism of NNK in Japanese Americans

Effects of E-Cigarette Flavors on Adults TCORS 2.0

Vaping High vs. Low Nicotine E-Liquid

The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book

Understanding Oral Nicotine Pouch Use in Healthy Volunteers

Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes

Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer

Imaging the Neurochemistry of Drug Addiction With PET

Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches