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ClinicalTrials.gov public records Last synced Oct 23, 2026, 2:28 PM EDT

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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Humidified oxygen Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)

NCT01764165
View directory record Official record
Conditions
COPD
Interventions
Oxygen, High flow of room air
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 80 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Epigenetic Effects of Diesel Exhaust and Ozone Exposure

NCT01492517
View directory record Official record
Conditions
Exposure to Pollution, Inhalation of Ozone
Interventions
Ozone exposure, Diesel exhaust, Ozone18, Clean Air
Other
Lead sponsor
Environmental Protection Agency (EPA)
Federal
Eligibility
18 Years to 55 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2016 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Study of Humidified Air to Improve Mucociliary Clearance (MCC) in COPD

NCT03935932
View directory record Official record
Conditions
COPD
Interventions
nasal delivery of heated and humidified air
Device
Lead sponsor
Frank C Sciurba
Other
Eligibility
40 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

Tolerance and Acute Effects of a New HFNT Nasal Cannula

NCT05182294
View directory record Official record
Conditions
COPD Exacerbation Acute
Interventions
AIRVO 2, the new asymmetric nasal cannula
Device
Lead sponsor
Temple University
Other
Eligibility
40 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation

NCT01925534
View directory record Official record
Conditions
Acute Respiratory Failure, Treatment With Noninvasive Positive Pressure Ventilation
Interventions
High-flow humidified nasal oxygen delivery system, Standard oxygen therapy
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Winchester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

High-flow Nasal Oxygen Therapy for Advanced Endoscopy in High-risk Patients.

NCT06610461
View directory record Official record
Conditions
Hypoxemia During Surgery
Interventions
HFNO-Treatment
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing

NCT02514798
View directory record Official record
Conditions
COPD
Interventions
Esophageal and gastric balloons, Respiratory Inductance Plethysmography (RIP) system, Sentec transcutaneous monitoring system, High-flow humidified nasal oxygen delivery system, CPAP (Positive Control)
Other · Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 23, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Results available

Helium-oxygen Gas Mixtures Delivered by a High Flow Nasal Cannula in Bronchiolitis

NCT02373683
View directory record Official record
Conditions
Bronchiolitis, Heliox, Pediatrics
Interventions
Vapotherm-Heliox
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
Up to 2 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

NCT03214458
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Nasal high flow
Device
Lead sponsor
Temple University
Other
Eligibility
40 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 19, 2018 · Synced Oct 23, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Results available

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

NCT01270581
View directory record Official record
Conditions
Transient Tachypnea of the Newborn
Interventions
High Flow Nasal Cannula, Bubble Nasal CPAP
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Up to 24 Hours
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 16, 2017 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Impact of High-Flow Nasal Cannula on Swallow Function

NCT03590457
View directory record Official record
Conditions
Swallowing Disorder, Respiratory Insufficiency
Interventions
Airvo 2; High-Flow nasal cannula system
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

THRIVE Use in Pediatric Populations- Multi Site

NCT04322994
View directory record Official record
Conditions
Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
Interventions
Transnasal Humidified Rapid-Insufflation Ventilatory Echange
Device
Lead sponsor
Stanford University
Other
Eligibility
Up to 18 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
5
States / cities
Palo Alto, California • Chicago, Illinois • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 23, 2026, 2:28 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

NCT02860975
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Inhaled Nitrogen
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula

NCT04782817
View directory record Official record
Conditions
Intubation, Cardiovascular Surgical Procedure
Interventions
Recommendation for high flow nasal cannula oxygen therapy order set, Provider choice standard care order set
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
3,568 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Efficacy, Safety and Economic Benefits of Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

NCT02326337
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
TWO2 Device, Placebo Device
Device
Lead sponsor
AOTI Ltd.
Industry
Eligibility
18 Years to 89 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
10
States / cities
Phoenix, Arizona • Vacaville, California • Washington D.C., District of Columbia + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

High-Flow Oxygen Therapy Following Tracheostomy

NCT03721419
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
High Flow High Humidity device, Low Flow High Humidity device
Device
Lead sponsor
Barnes-Jewish Hospital
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers

NCT03905863
View directory record Official record
Conditions
Diabetic Foot Ulcer, Surgical Wound
Interventions
Natrox® Oxygen Wound Therapy
Device
Lead sponsor
Inotec AMD Limited
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
19
States / cities
Los Angeles, California • Miami, Florida • Miami Lakes, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome

NCT02587832
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
HHHFNC, NCPAP
Device
Lead sponsor
Sidra Medicine
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients

NCT03221387
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxia
Interventions
Humidified nasal high flow with oxygen
Device
Lead sponsor
Temple University
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures

NCT03430206
View directory record Official record
Conditions
Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
Interventions
High-flow nasal cannula
Device
Lead sponsor
Stanford University
Other
Eligibility
Up to 18 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2020 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy

NCT03086408
View directory record Official record
Conditions
Bronchoscopy
Interventions
THRIVE, Endotracheal tube or Supraglottic airway
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2020 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Results available

Heated Humidified Oxygen Compared to Dry Oxygen Therapy in Children With Bronchiolitis

NCT02094664
View directory record Official record
Conditions
Bronchiolitis, Hypoxemia
Interventions
Heated and humidified oxygen
Device
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
Up to 24 Months
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula With Noninvasive Ventilation

NCT04507425
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Standard of Care - Nasal Cannula, High-flow nasal cannula, HFNC plus non-invasive ventilation
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 23, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transnasal Therapy for Acute Migraine Attack

NCT04129567
View directory record Official record
Conditions
Migraine Disorders
Interventions
Humidified oxygen, Dry oxygen, Humidified air, Dry air
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2020 · Synced Oct 23, 2026, 2:28 PM EDT