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ClinicalTrials.gov public records Last synced Oct 2, 2026, 3:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Hypertonic Saline (3% NaCl) Clear all

Conditions: Cystic Fibrosis
Interventions: Xylitol, Hypertonic saline; Drug
Lead sponsor: Joseph Zabner; Other
Eligibility: 16 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Chicago, Illinois

Conditions: Chronic Subdural Hematoma
Interventions: Dextrose 5% W/ Sodium Chloride 0.225%; Drug
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Pancreaticoduodenectomy
Interventions: 3% NaCl Solution, Lactated Ringers Solution; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 264 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cystic Fibrosis
Interventions: Hypertonic Saline, Placebo; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 5 Years to 12 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cystic Fibrosis
Interventions: Discontinuation of hypertonic saline (HS), Continuation of hypertonic saline (HS); Other
Lead sponsor: Nicole Hamblett; Other
Eligibility: 12 Years and older
Enrollment: 370 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 81
States / cities: Birmingham, Alabama • Anchorage, Alaska • Tucson, Arizona + 69 more

Conditions: Bronchiolitis
Interventions: Nebulized 3% saline, Nebulized 0.9% saline; Drug
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: Up to 24 Months
Enrollment: 447 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Los Angeles, California • Oakland, California

Conditions: Bronchiolitis, Viral, Saline Solution, Hypertonic
Interventions: Nebulized 3% saline, Nebulized 0.9% Normal Saline; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 2 Months to 23 Months
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Traumatic Brain Injury
Interventions: Mannitol, NaCl; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Water Stress, Body Water Dehydration
Interventions: Hypertonic Saline, Normal Saline; Other
Lead sponsor: University of North Carolina, Greensboro; Other
Eligibility: 18 Years to 35 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Greensboro, North Carolina

Conditions: Respiratory Failure
Interventions: Hypertonic saline (3%), Placebo (0.9% saline); Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: Up to 18 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Salt Sensitivity of Blood Pressure
Interventions: Hypertonic Saline with furosemide, Hypertonic Saline without furosemide; Other
Lead sponsor: University of Delaware; Other
Eligibility: 18 Years to 45 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Insulin Resistance
Interventions: Hypertonic Saline (3% NaCl), Isotonic Saline (0.9% NaCl); Other
Lead sponsor: University of Arkansas, Fayetteville; Other
Eligibility: 30 Years to 50 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Fayetteville, Arkansas

Conditions: Primary Ciliary Dyskinesia
Interventions: VX-371, Hypertonic Saline, Placebo (0.17% saline), VX-371 + HS, Ivacaftor; Drug
Lead sponsor: Parion Sciences; Industry
Eligibility: 12 Years and older
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 21
States / cities: Birmingham, Alabama • Palo Alto, California • Aurora, Colorado + 18 more

Conditions: Brain Concussion, Post-Concussion Symptoms
Interventions: 3% Hypertonic saline, Placebo; Drug
Lead sponsor: Rady Children's Hospital, San Diego; Other
Eligibility: 6 Years to 17 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: San Diego, California

Conditions: Atelectasis
Interventions: Normal saline:, Hypertonic Saline, Dornase alpha; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 90 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Head Injury, Minor, Pediatric, Emergency Department Patient
Interventions: Hypertonic Saline ( 3% Sodium Chloride Saline), Normal Saline (0.9% NaCl); Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 8 Years to 17 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Salt-Sensitivity of Blood Pressure
Interventions: Furosemide (Diuretic), Hypertonic Saline Infusion; Drug · Other
Lead sponsor: University of Delaware; Other
Eligibility: 40 Years to 60 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
Interventions: Hypertonic 3% saline; Drug
Lead sponsor: Rochester General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cerebral Edema, Saline Solution, Hypertonic
Interventions: 3% Sodium Chloride, 23.4% Sodium Chloride, 8.4% Sodium Bicarbonate; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Stanford, California

Conditions: Hidradenitis Suppurativa
Interventions: 23.4% Hypertonic saline; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Bronchiolitis
Interventions: Nebulized 3% sodium chloride solution, Chest percussion cups; Drug · Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 0 Months to 24 Months
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Mineola, New York

Conditions: Bronchiolitis
Interventions: 3% sodium chloride, 0.9% sodium chloride; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: Up to 12 Months
Enrollment: 227 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: The Bronx, New York

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Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

Effect of Different Intravenous Fluids on Post-operative Chronic Subdural Hematoma Size and Recurrence

The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy

Effect of Hypertonic Saline on Mucus Clearance in Children Ages 5-12 With Cystic Fibrosis

Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study

Nebulized Hypertonic Saline for Bronchiolitis

Hypertonic Saline for Acute Bronchiolitis

Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury

Influence of Osmotic Stimulation of Vasopressin on Autonomic Function

Nebulized Hypertonic Saline for Mechanically Ventilated Children

Central Sodium Sensing: Implications for Blood Pressure Regulation

The Effect of Vasopressin on Glucose Regulation

Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia

Use of Salt-Water Solution to Improve Symptoms in Concussion

Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis in Non-Cystic Fibrosis Patients

Hypertonic Saline for Mild TBI in Pediatric Patients

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation

Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa

Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis

A Study of Hypertonic Saline for Infants Hospitalized With Bronchiolitis