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ClinicalTrials.gov public records Last synced Sep 10, 2026, 3:29 AM EDT

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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Cardiogenic Shock, High Risk PCI
Interventions
Impella CP, 2.5, 5.0 and 5.5 with Sodium Bicarbonate used as purge solution, Impella RP with Sodium Bicarbonate used as purge solution
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
Not listed
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
20
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 14 more
Conditions
Left Ventricular Dysfunction, Coronary Artery Disease
Interventions
Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
1,252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
83
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 65 more
Conditions
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Interventions
Impella CP® placement prior to reperfusion with Primary PCI
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
527 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
46
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tucson, Arizona + 41 more
Conditions
Coronary Artery Disease, High Risk Percutaneous Coronary Intervention, Interventional Cardiology, Mechanical Circulatory Support
Interventions
The Supira System, Impella
Device
Lead sponsor
Supira Medical
Industry
Eligibility
18 Years to 90 Years
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
19
States / cities
Loma Linda, California • Sacramento, California • Thousand Oaks, California + 15 more
Active, not recruiting Not applicable Interventional

The Smart Pump Study

NCT04465201
Conditions
Cardiac Output
Interventions
Impella CP with Smart Assist (Circulatory Support System)
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
New Orleans, Louisiana • Boston, Massachusetts • Detroit, Michigan + 2 more
Conditions
Hemolysis Intravascular, Acute Decompensated Heart Failure
Interventions
Pentoxifylline Oral Product, Placebo
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Terminated Not applicable Interventional

The RECOVER IV Trial

NCT05506449
Conditions
ST-segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock
Interventions
Impella CP®, Standard of Care
Device · Other
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Conditions
Cardiogenic Shock
Interventions
Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Completed No phase listed Observational Results available

National Cardiogenic Shock Initiative

NCT03677180
Conditions
Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Heart Attack
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
75
States / cities
Birmingham, Alabama • Fayetteville, Arkansas • Little Rock, Arkansas + 61 more
Conditions
End-stage Heart Failure
Interventions
Echocardiographic Assessment
Diagnostic Test
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, New York
Conditions
STEMI
Interventions
Impella unloading prior to PPCI
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
15
States / cities
Phoenix, Arizona • Marietta, Georgia • Detroit, Illinois + 12 more
Conditions
Heart Failure, Acute Decompensated Heart Failure
Interventions
Impella BTR
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
6
States / cities
Atlanta, Georgia • Evanston, Illinois • Boston, Massachusetts + 2 more
Not listed No phase listed Observational

Protected PCI Study

NCT02831881
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
369 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Detroit, Michigan
Terminated Not applicable Interventional Results available

SHIELD II Clinical Investigation

NCT02468778
Conditions
Coronary Artery Disease
Interventions
HeartMate PHP, Any Abiomed Impella® device approved for use in high-risk PCI
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 100 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
58
States / cities
Scottsdale, Arizona • Tucson, Arizona • Los Angeles, California + 43 more
Conditions
Coronary Artery Disease
Interventions
Early Bird® Bleed Monitoring System, Impella®
Device
Lead sponsor
Saranas, Inc.
Industry
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
11
States / cities
Phoenix, Arizona • Tucson, Arizona • Gary, Indiana + 7 more
Conditions
Left Ventricular Dysfunction
Interventions
Impella 5.5 with SmartAssist
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Jonesboro, Arkansas • Los Angeles, California • San Diego, California + 15 more
Conditions
Cardiogenic Shock, STEMI
Interventions
SSO2 Downstream System, PCI + Impella
Device · Procedure
Lead sponsor
TherOx
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
7
States / cities
Miami, Florida • Springfield, Massachusetts • Detroit, Michigan + 4 more
Conditions
Right Heart Failure
Interventions
IMPELLA® RP
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Detroit, Michigan • Philadelphia, Pennsylvania
Conditions
AMI Cardiogenic Shock
Interventions
Impella
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
18
States / cities
Jonesboro, Arkansas • Orange, California • Torrance, California + 14 more
Recruiting Not applicable Interventional

ELEVATE High-Risk PCI Pivotal Study

NCT07001332
Conditions
High-Risk Percutaneous Coronary Intervention (High-risk PCI)
Interventions
Elevate, Impella
Device
Lead sponsor
Magenta Medical Ltd.
Industry
Eligibility
18 Years to 88 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
33
States / cities
Phoenix, Arizona • Scottsdale, Arizona • La Jolla, California + 23 more
Conditions
High-Risk Percutaneous Coronary Intervention
Interventions
Impella ECP
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
856 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
32
States / cities
Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 27 more
Conditions
Ventricular Tachycardia
Interventions
Circulatory Support System
Device
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Conditions
Cardiogenic Shock
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Recruiting No phase listed Observational

Impella RP Flex with Smart Assist

NCT06637644
Conditions
Right Ventricular (RV) Dysfunction
Interventions
Right-sided ventricular assist device
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
31
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 23 more