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Conditions: Opioid Use Disorder
Interventions: care coordination implementation strategies; Other
Lead sponsor: University of California, Davis; Other
Eligibility: 14 Years and older
Enrollment: 3,492 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 4
States / cities: El Centro, California • Irvine, California • Placerville, California + 1 more

Conditions: Cardiometabolic Conditions, Hypertension (HTN), Dyslipidemia, Pre-diabetes, Type 2 Diabetes Mellitus (T2DM), Overweight (BMI > 25), Weight Loss Trial
Interventions: PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program; Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Fayetteville, Arkansas • Honolulu, Hawaii

Conditions: Cervical Cancer, Human Papillomavirus, Health Knowledge, Attitudes, Practice, Health Care Utilization
Interventions: Local Tailoring; Other
Lead sponsor: Chun Chao; Other
Eligibility: 21 Years to 70 Years
Enrollment: 45,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Pasadena, California

Conditions: Substance Use Disorder, Mental Health Disorder, Homelessness
Interventions: Employing Peer Outreach and Whole Health in Recovery (EMPOWER); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 278 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Alcohol Use Disorder, Alcohol-related Liver Disease
Interventions: Connections App; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 298 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Lansing, Michigan • Madison, Wisconsin

Conditions: Violence in Adolescence
Interventions: Narrative Persuasion, Reciprocity, Personalized Feedback, Commitment; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 6
States / cities: Ann Arbor, Michigan • Fruitport, Michigan • Muskegon, Michigan

Conditions: Opioid-use Disorder
Interventions: Prescriber Recruitment Bundle (PRB); Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: Not listed
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 3
States / cities: Tallahassee, Florida • Columbus, Ohio • Madison, Wisconsin

Conditions: Work-related Injury
Interventions: individual -Brief Motivational Intervention (BMI), Group (Group Problem Solving), Standard of Care (OSHA 10 Safety Cards); Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 325 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Suicide
Interventions: Crisis Line Facilitation (CLF), Passive Implementation; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 538 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Sedentary Behavior
Interventions: Stand & Move at Work+; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years and older
Enrollment: 4,800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: First-Episode Psychosis
Interventions: Financial Incentive and Text-Messages; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 145 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Raleigh, North Carolina • Philadelphia, Pennsylvania • Philadephia, Pennsylvania

Conditions: Colorectal Cancer
Interventions: Intervention Phase 1: Provider and Staff education, Intervention Phase 2: Provider and staff education + Patient reminder, Intervention Phase 3: Provider and Staff education + Patient reminder + Patient navigation; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 50 Years to 75 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Oak Park, Illinois

Conditions: Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired, Aphasia, Rehabilitation, Aphasia, Anomic, Aphasia, Broca, Aphasia, Conduction, Aphasia, Expressive, Aphasia Non Fluent, Aphasia, Mixed
Interventions: Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training; Behavioral
Lead sponsor: Teachers College, Columbia University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Sexual Violence, College Drinking, Behavioral Changes
Interventions: Friend-Based Motivational Interview, Treatment as usual (TAU); Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years to 24 Years · Female only
Enrollment: 560 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Community Mental Health Services
Interventions: EASE; Behavioral
Lead sponsor: The New School; Other
Eligibility: 10 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: COVID-19, Vaccine Hesitancy
Interventions: Health Communication, Health Communication + Structural; Behavioral
Lead sponsor: Marc Kiviniemi; Other
Eligibility: 18 Years to 99 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Hazard, Kentucky

Conditions: Contrast-induced Nephropathy
Interventions: Exposure to CBCIN risk score; Other
Lead sponsor: University of Chicago; Other
Eligibility: 21 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Copd
Interventions: Interprofessional Education (IPE), Usual care; Other
Lead sponsor: Baystate Medical Center; Other
Eligibility: 23 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Springfield, Massachusetts

Conditions: Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
Interventions: Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment; Behavioral
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: Not listed
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Sickle Cell Trait
Interventions: SCT Documentation and Disclosure Toolkit (SCT-DD); Behavioral
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: Not listed
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Smoking Cessation
Interventions: Academic Detailing, Community Health Worker, Treatment as Usual (TAU); Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-use Disorder
Interventions: Addiction Technology Transfer Center (ATTC) Training Strategy, Enhanced Addiction Technology Transfer Center (E-ATTC) Training Strategy; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 29
States / cities: Bridgeport, Connecticut • Hartford, Connecticut • Stamford, Connecticut + 22 more

Conditions: Food Deprivation, Obesity, Childhood
Interventions: Implementation Mapping, Waitlist Comparison - Implementation Mapping; Other
Lead sponsor: Temple University; Other
Eligibility: 11 Years to 99 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Child Development, Child Behavior
Interventions: PBIS, HELM; Behavioral · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Seattle, Washington

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Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years

Comparing Strategies for Implementing Primary HPV Screening

Employing Peer Outreach and Whole Health in Recovery for Homeless-Experienced Veterans

Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease

Michigan Youth Violence Prevention Center: Building Evidence for Gun Violence Prevention - SafERteens Implementation

Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers

VALES+Tú: Targeting Psychosocial Stressors to Reduce Latino Day Laborers (LDL) Injury Disparities

Connecting National Guard Service Members Through Education in Crisis Line Facilitation Training

Stand & Move at Work II: Effectiveness and Implementation of a Worksite Wellness Program

Trial to Increase FEP Attendance

Implementing a Multilevel Intervention to Accelerate Colorectal Cancer Screening and Follow-up

Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)

PAIRS: Friend-Based AISA Intervention

Early Adolescent Skills for Emotions

Addressing COVID-19 Vaccine Hesitancy With Muliti-Level Interventions in Appalachia

Automated Prediction and Prevention of Contrast Induced Nephropathy After Cardiac Catheterization

The Impact of Interprofessional Training to Improve the Uptake of Noninvasive Ventilation in Patients Hospitalized With Severe COPD Exacerbation

Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching

Increasing Documentation and Disclosure of Sickle Cell Trait Status: An Implementation Science Approach

Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness

Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics)

Improving Participation in Universal School Meals (USM)

Impact Trial of Helping Educational Leaders Mobilize Evidence