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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Inspiratory muscle training (IMT) Clear all
Completed Not applicable Interventional

Orthostatic, Respiratory, Balance-Intervention

NCT04210063
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Inspiratory Muscle Training (IMT)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 10, 2020 · Synced Sep 28, 2026, 8:33 AM EDT
Not listed Not applicable Interventional

Inspiratory Muscle Training in COPD

NCT03438019
View directory record Official record
Conditions
COPD
Interventions
PrO2, Threshold Inspiratory Muscle Trainer
Device
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)

NCT06336681
View directory record Official record
Conditions
Exercise Induced Bronchospasm, Exercise Induced Asthma
Interventions
PrO2Fit Device
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Respiratory Muscle Training (RMT) in ALS

NCT04224961
View directory record Official record
Conditions
ALS
Interventions
Respiratory Muscle Training
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

Inspiratory Muscle Training in HFpEF

NCT06510231
View directory record Official record
Conditions
Heart Failure
Interventions
Inspiratory Muscle Training
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

NCT05440851
View directory record Official record
Conditions
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT
Other · Drug
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
6,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
26
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional

High Dose Inspiratory Muscle Training in LOPD

NCT05431127
View directory record Official record
Conditions
Late-Onset Pompe Disease, Lysosomal Disease
Interventions
IMT therapy using the Pr02 mobile device
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Inspiratory Muscle Training in Obese Breast Cancer Survivors

NCT05193149
View directory record Official record
Conditions
Cancer Survivors, Obesity, Breast Cancer
Interventions
Inspiratory muscle training, Exercise training
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure

NCT06576297
View directory record Official record
Conditions
Aging, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Frailty, Physical Function, Quality of Life
Interventions
Inspiratory Muscle Training (IMT), Standard of Care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
70 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Diaphragm Structure and Function in Childhood Cancer Survivors

NCT06205251
View directory record Official record
Conditions
Childhood Cancer, Cancer Survivors
Interventions
POWERbreathe Plus IMT
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
6 Years to 12 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

NCT07086131
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
Powerbreathe
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional

A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma

NCT03911206
View directory record Official record
Conditions
Asthma
Interventions
Inspiratory muscle training (IMT), Exercise alone, IMT and Exercise
Behavioral
Lead sponsor
Duke University
Other
Eligibility
10 Years to 17 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Respiratory Muscle Training on Cognitive Performance

NCT07637331
View directory record Official record
Conditions
Respiratory Muscle Training
Interventions
Inspiratory muscle training
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

Management of Dyssynergic Defecation

NCT07225803
View directory record Official record
Conditions
Dyssynergic Defecation, Constipation
Interventions
Biofeedback, Inspiratory muscle training (IMT)
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery

NCT05381818
View directory record Official record
Conditions
Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
Interventions
Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional

Effects of Inspiratory Muscle Training in Persons With Advanced Multiple Sclerosis

NCT03345199
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Inspiratory Muscle Trainer (IMT)
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts • Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Sep 28, 2026, 8:33 AM EDT
Recruiting Not applicable Interventional

Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury

NCT06019949
View directory record Official record
Conditions
Spinal Cord Injuries, Respiration Disorders
Interventions
Transcutaneous spinal cord stimulator, Respiratory Training
Device
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Not listed Not applicable Interventional

Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19

NCT04887272
View directory record Official record
Conditions
Covid19
Interventions
Supervised Exercise Training Protocol, Inspiratory Muscle and Exercise Training
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU

NCT02003053
View directory record Official record
Conditions
Critically Ill, Respiratory Failure
Interventions
Inspiratory Muscle Trainer
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inspiratory Muscle Training in Postmenopausal Women

NCT06459674
View directory record Official record
Conditions
Postmenopausal Symptoms, Aging, Obesity
Interventions
PrO2 Fit (IMT Trainer)
Device
Lead sponsor
Indiana University
Other
Eligibility
50 Years to 75 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 28, 2026, 8:33 AM EDT
Not listed Not applicable Interventional

Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease

NCT06304207
View directory record Official record
Conditions
Copd, COPD Exacerbation, COPD Bronchitis, Emphysema or COPD, Chronic Lung Disease, Pulmonary Fibrosis, Interstitial Lung Disease, Bronchiectasis, Chronic Asthma, Chronic Asthmatic Bronchitis
Interventions
Onsite Maintenance Exercise Training, Telehealth Maintenance Exercise
Combination Product
Lead sponsor
MGH Institute of Health Professions
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Sep 28, 2026, 8:33 AM EDT
Withdrawn Not applicable Interventional

Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery

NCT02843750
View directory record Official record
Conditions
Cancer of Esophagus, Cancer of the Esophagus, Esophageal Cancer, Esophagus Cancer, Esophagus Neoplasm, Neoplasms, Esophageal
Interventions
Inspiratory Muscle Training-Rehabilitation, Questionnaires
Behavioral · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

Respiratory Muscle Strength Training in Presbyphonia

NCT03557775
View directory record Official record
Conditions
Presbylarynx
Interventions
Inspiratory Muscle Strength Training (IMST), Expiratory Muscle Strength Training (EMST), Voice Exercises
Device · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 28, 2026, 8:33 AM EDT
Completed Not applicable Interventional Results available

High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease

NCT06127147
View directory record Official record
Conditions
Coronary Artery Bypass Graft, CABG
Interventions
IMT, Sham-IMT
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 28, 2026, 8:33 AM EDT