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ClinicalTrials.gov public records Last synced Nov 4, 2026, 9:40 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Intermediate nicotine level cigarette Clear all

Conditions: Cigarette Smoking Behavior
Interventions: Control, Product Category Score, Product Category Rank, Product Tiers; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Healthy Volunteers
Interventions: Myblu flavor A_2.4, Myblu flavor B_2.4, Myblu flavor C_2.4, Myblu flavor D_2.4, Myblu flavor E_1.2, Myblu flavor F_1.2, Myblu flavor G_2.4, Myblu flavor H_2.4; Other
Lead sponsor: Fontem US LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Pulmonary Disease, Chronic Obstructive, E-cigarettes
Interventions: E-cigarette, Sham, Hyperpolarized 3-Helium, Gadolinium; Device · Other · Drug
Lead sponsor: Columbia University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette, Smoking Behaviors, Cigarette Smoking Behavior
Interventions: Mentholated cigarette sampling, Hypothetical Policy Scenarios, Subjective value assessment; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Tobacco Use, Nicotine Pouch Self-Administration
Interventions: Nicotine Pouch Dosage; Other
Lead sponsor: William Middleton; Other
Eligibility: 18 Years and older
Enrollment: 1,360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Nicotine Dependence, E-cigarette Use
Interventions: Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml); Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking, Cigarette, Electronic Cigarette Use
Interventions: Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 21 Years to 34 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence
Interventions: nicotine, menthol; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: West Haven, Connecticut

Conditions: Nicotine Addiction, Panic Attack
Interventions: d-cycloserine, Pill Placebo, Nicotine replacement therapy, Panic and Smoking Reduction Treatment; Drug · Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 65 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Smoking, Tobacco
Interventions: P2613422, P2611222, P2615522, P2615122, P2615422; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 1,280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 7
States / cities: Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more

Conditions: Nicotine Dependence
Interventions: NJOY King 26 mg nicotine Electronic Nicotine Delivery System; Other
Lead sponsor: LA Clinical Trials; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Burbank, California

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Biospecimen Collection, Oral nicotine pouches, Survey Administration; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking, Tobacco
Interventions: P1213416, P1213422, P1213716, P1213722, P1211216, P1211222, P1213616, P1213622, P1213816, P1213822, P1211916, P1211922; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 1,845 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 12
States / cities: Phoenix, Arizona • Fort Lauderdale, Florida • Orlando, Florida + 9 more

Conditions: Tobacco Use Disorder
Interventions: Bupropion and NRT; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 407 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Cigarettes
Interventions: AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 14 Years to 20 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking, Smoking Behaviors
Interventions: Switching to E-Cigarette, Switching using Medication; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 225 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions: Electronic Cigarette, Oral Nicotine Pouch; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking
Interventions: Culturally Targeted Cessation Program, Non-Targeted Cessation Program; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 65 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cigarette Addiction, Tobacco Use Disorder
Interventions: Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task, Cross-Price Elasticity Task, Daily Diary Surveys, Progressive Ratio Task; Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions: E-cigarettes, Oral nicotine pouches; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: E-cigarette Use
Interventions: ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence
Interventions: Transcranial Direct Current Stimulation, sham, Nicotine patch, Placebo patch, Varenicline Pill, Placebo pill, Motivational Interviewing; Device · Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking, Tobacco, Smoking (Tobacco) Addiction
Interventions: Cigarette 1, Cigarette 2, Patch 1, Patch 2; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 221 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking Cessation, Nicotine Dependence
Interventions: NicoBloc, Nicotine Lozenge; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Birmingham, Alabama

Search by objective public record fields.

Effects of Tobacco Abuse Liability-dependent Taxes in the ETM

A Study to Evaluate Nicotine Uptake and Biomarkers in Adult Smokers Using mybluTM Electronic Cigarettes

Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study

An Experimental Evaluation of Menthol-Flavored Tobacco Accessories

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

Sex Differences in E-Cigarette Perception

Dual Use of ENDS and Combustible Cigarettes

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

Studying Different Ways of Using Oral Nicotine Pouches to Understand the Effect on Nicotine Delivery, Appeal, and Side Effects Among Adult Cigarette Smokers

CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

Switch or Quit R01

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

Nicotine Withdrawal Symptoms and Smoking Relapse

Effects of Nicotine in Tobacco Smokers

Comparing NicoBloc to Nicotine Lozenges