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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Intermediate nicotine level cigarette Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-Cigarette Perception

NCT07398976
View directory record Official record
Conditions
Nicotine Dependence, E-cigarette Use
Interventions
Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

NCT01990079
View directory record Official record
Conditions
PTSD, Smoking
Interventions
Bupropion, nicotine replacement therapy, Smoking cessation counseling, mobile contingency management, Stay Quit Coach
Drug · Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Nicotine in Tobacco Smokers

NCT03651869
View directory record Official record
Conditions
Smoking, Tobacco, Smoking (Tobacco) Addiction
Interventions
Cigarette 1, Cigarette 2, Patch 1, Patch 2
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Results available

Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

NCT05177848
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Vaping
Interventions
All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price, Heated tobacco products at 1/2 market price., Heated tobacco products at 2x market price., Nicotine pouch products at 1/2 market price., Nicotine pouch products at 2x market price.
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers

NCT05960305
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P1213416, P1213422, P1213716, P1213722, P1211216, P1211222, P1213616, P1213622, P1213816, P1213822, P1211916, P1211922
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
1,845 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
12
States / cities
Phoenix, Arizona • Fort Lauderdale, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 4 Interventional Results available

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

NCT02420015
View directory record Official record
Conditions
Schizophrenia, Cigarette Smoking
Interventions
Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging
Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace

NCT02951143
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
SPECTRUM cigarettes, SPECTRUM cigarettes between
Drug
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

NCT07213947
View directory record Official record
Conditions
Tobacco Use, Nicotine Pouch Self-Administration
Interventions
Nicotine Pouch Dosage
Other
Lead sponsor
William Middleton
Other
Eligibility
18 Years and older
Enrollment
1,360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Motivation and Skills for Detained Teen Smokers

NCT01387516
View directory record Official record
Conditions
Motivational Intervention, Nicotine Anonymous, Cognitive Behavior Therapy, Relaxation Therapy
Interventions
Motivational Intervention, Relaxation Therapy, Cognitive Behavioral Therapy, Self-Help Programming
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
13 Years to 19 Years
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Cranston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

NCT01633567
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Culturally Targeted Cessation Program, Non-Targeted Cessation Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interventions for Smoking Among Persons in Recovery

NCT00714896
View directory record Official record
Conditions
Smoking Cessation
Interventions
Stepped-Care, Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated May 28, 2013 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Results available

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

NCT05458895
View directory record Official record
Conditions
E-cigarette Use
Interventions
ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Sep 17, 2026, 12:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

NCT07598136
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P2613422, P2611222, P2615522, P2615122, P2615422
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
1,280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
7
States / cities
Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Palatability of Experimental Cigarettes - Study 2

NCT01568905
View directory record Official record
Conditions
Smoking
Interventions
Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 17, 2026, 12:32 AM EDT
Not yet recruiting Not applicable Interventional

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

NCT06965296
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
14 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 4 Interventional Results available

Identifying Treatments to Motivate Smokers to Quit

NCT01122238
View directory record Official record
Conditions
Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions
Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 15, 2015 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

NCT02989038
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Very Low Nicotine Content Cigarettes, Intermediate Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 17, 2026, 12:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

NCT06264154
View directory record Official record
Conditions
Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use
Interventions
E-cigarettes
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

NCT00087880
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion and NRT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 4 Interventional Results available

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

NCT02995915
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring
Other · Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Not applicable Interventional Results available

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

NCT04965181
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Mindfulness-Based Addiction Treatment, Nicotine Replacement Therapy, Self-help materials, iQuit Mindfully
Behavioral · Drug
Lead sponsor
Georgia State University
Other
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 17, 2026, 12:32 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Comparing NicoBloc to Nicotine Lozenges

NCT03720899
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
NicoBloc, Nicotine Lozenge
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 17, 2026, 12:32 AM EDT
Completed No phase listed Observational Results available

Cognition and Smoking Relapse (HCS)

NCT03169101
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine patch, Behavioral counseling
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Sep 17, 2026, 12:32 AM EDT