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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:20 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 961–984 of 1,792 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Intervention 2 - Sham Treatment Clear all

Conditions: Metastatic Breast Adenocarcinoma, Metastatic HER2-Positive Breast Carcinoma, Recurrent Breast Adenocarcinoma, Recurrent HER2-Positive Breast Carcinoma, Stage III Breast Cancer AJCC v7, Stage IV Breast Cancer AJCC v6 and v7, Unresectable Breast Carcinoma, Unresectable HER2-Positive Breast Carcinoma
Interventions: Atezolizumab, Biopsy, Bone Scan, Computed Tomography, Docetaxel, Magnetic Resonance Imaging, Paclitaxel, Pertuzumab, Placebo Administration, Quality-of-Life Assessment, Trastuzumab; Drug · Procedure · Biological + 1 more
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 662
States / cities: Birmingham, Alabama • Anchorage, Alaska • Gilbert, Arizona + 506 more

Conditions: Dravet Syndrome
Interventions: zorevunersen, Sham Comparator; Drug · Other
Lead sponsor: Stoke Therapeutics, Inc; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 28
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 23 more

Conditions: Post-concussive Symptoms, Traumatic Brain Injury
Interventions: hyperbaric oxygen, sham hyperbaric air; Drug · Other
Lead sponsor: U.S. Army Medical Research and Development Command; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 5
States / cities: Camp Pendleton, California • Fort Carson, Colorado • Fort Gordon, Georgia + 2 more

Conditions: Occupational Therapy Students
Interventions: Mindful Self Care Survey (MSCS), Placebo; Behavioral · Other
Lead sponsor: Lauren Newhouse; Other
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Carson, California

Conditions: Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder
Interventions: Non-deceptive placebo (NDP); Other
Lead sponsor: Miami University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 330 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Oxford, Ohio

Conditions: Age-associated Memory Impairment
Interventions: Transcranial Magnetic Stimulation (TMS) Cone Coil, Transcranial Magnetic Stimulation (TMS) Sham Coil; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 60 Years to 85 Years
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Fibromyalgia
Interventions: RINCE; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Exercise Induced Fatigue
Interventions: Palmar Cooling, Placebo Palmar Cooling; Device
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 18 Years to 30 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Accidental Falls
Interventions: Tailored home intervention, Sham intervention; Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 65 Years and older
Enrollment: 129 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Social Anxiety, Social Anxiety Disorder
Interventions: Online Interpretation Training Condition 1, Online Interpretation Training Condition 2; Behavioral
Lead sponsor: University of Wisconsin, Milwaukee; Other
Eligibility: 8 Years to 12 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Overactive Bladder
Interventions: Posterior Tibial Nerve Device, Sham; Device
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Cognitive Performance, Memory, Mood, Anxiety
Interventions: Muscadine Wine Polyphenol, Placebo; Other
Lead sponsor: University of Florida; Other
Eligibility: 50 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Constipation, Cancer, Functional Constipation
Interventions: MZRW; Dietary Supplement
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Abortion, Induced, Cervical Preparation, Pain
Interventions: Gabapentin 600mg, Placebo oral capsule, acetaminophen/codeine and ibuprofen; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years and older · Female only
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Acute Stress Reaction, Acute Stress Disorder, Post-traumatic Stress Disorder
Interventions: BXCL501 (dexmedetomidine HCl), Placebo; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 3
States / cities: Jacksonville, Florida • St Louis, Missouri • Charlottesville, Virginia

Conditions: Insomnia, Malignant Solid Neoplasm
Interventions: Biospecimen Collection, Placebo Administration, Single Agent Therapy; Procedure · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 25 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: COVID-19
Interventions: Dietary Supplement containing resistant starch, Placebo Starch; Drug · Dietary Supplement
Lead sponsor: Yale University; Other
Eligibility: 19 Years and older
Enrollment: 226 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: New Haven, Connecticut • Ann Arbor, Michigan

Conditions: Stroke, Motor Function
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS); Device
Lead sponsor: Spaulding Rehabilitation Hospital; Other
Eligibility: 18 Years to 90 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoporosis
Interventions: esomeprazole, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Addiction, Panic Attack
Interventions: d-cycloserine, Pill Placebo, Nicotine replacement therapy, Panic and Smoking Reduction Treatment; Drug · Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 65 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Eosinophilic Esophagitis
Interventions: APT-1011, Placebo oral tablet, Esophagogastroduodenoscopy; Drug · Procedure
Lead sponsor: Ellodi Pharmaceuticals, LP; Industry
Eligibility: 18 Years and older
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 48
States / cities: Anniston, Alabama • Dothan, Alabama • Mobile, Alabama + 43 more

Conditions: Social Anxiety in Autistic Adults
Interventions: Placebo, Midomafetamine HCl, Therapy; Drug · Behavioral
Lead sponsor: Resilient Pharmaceuticals; Industry
Eligibility: 21 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Torrance, California

Conditions: Fatigue, Hypothyroidism
Interventions: Aromatherapy Blend, Placebo; Other
Lead sponsor: Nutraceuticals Research Institute; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Franklin, Tennessee

Search by objective public record fields.

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)

Enhancing Occupational Therapy Graduate Student Well-Being

Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms

TMS for Investigating Memory Facilitation

A Prospective Evaluation of RINCE to Reduce Fibromyalgia Effects - University of Michigan

The Effects of Palmar Cooling on Repeated Sprinting Ability

The Effectiveness of a Fall Prevention Program

Interpretive Biases in Children With Social Anxiety

Posterior Tibial Nerve Stimulation vs. Sham

Effects of Varenicline on Cigarette Self Administration

Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health

A Study of Herbal Supplements in Cancer Survivors With Constipation

Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial

BXCL501 After Stress to Increase Recovery Success

THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia

The Role of Resistant Starch in COVID-19 Infection

Effects of rTMS and tDCS on Motor Function in Stroke

The Effect of Protein on Calcium Absorption and Gastric Acid Production

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

Efficacy and Safety APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults

The Effect of Aroma on Fatigue Scores Among Women With Hypothyroidism