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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Intra Operative Radiation Therapy (IORT) Clear all
Recruiting Phase 1 Interventional

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

NCT04754321
View directory record Official record
Conditions
Head and Neck Carcinoma of Unknown Primary, Locally Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Oral Cavity Squamous Cell Carcinoma, Recurrent Pharyngeal Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma
Interventions
External Beam Radiation Therapy, Intraoperative Radiation Therapy, Pembrolizumab, Quality-of-Life Assessment, Salvage Surgery
Radiation · Biological · Other + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Not listed Phase 1Phase 2 Interventional

Radiation Therapy in Treating Patients Who Are Undergoing Surgery to Remove a Metastatic Brain Tumor

NCT00107367
View directory record Official record
Conditions
Metastatic Cancer
Interventions
conventional surgery, intraoperative radiation therapy
Procedure · Radiation
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Not applicable Interventional

IORT (Intra-operative Radiation Therapy) in Early Stage Breast Cancer

NCT01988870
View directory record Official record
Conditions
Breast Cancer
Interventions
Intra-operative Radiation Therapy (IORT)
Radiation
Lead sponsor
Shayna Showalter, MD
Other
Eligibility
50 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2016 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Not applicable Interventional Results available

Radiation Therapy in Treating Patients With Recurrent Breast Cancer

NCT00945061
View directory record Official record
Conditions
Breast Cancer
Interventions
intracavitary balloon brachytherapy, intraoperative radiation therapy
Radiation
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
3
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Phase 1 Interventional

Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue Sarcoma

NCT00004123
View directory record Official record
Conditions
Sarcoma
Interventions
Doxorubicin hydrochloride (DOX), Conventional surgery, Intraoperative radiation therapy (IORT), Radiation Therapy (RT)
Drug · Procedure · Radiation
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2012 · Synced Sep 16, 2026, 2:13 PM EDT
Not listed Phase 1 Interventional

Combining Intraoperative Radiotherapy With Kyphoplasty for Treatment of Spinal Metastases

NCT02480036
View directory record Official record
Conditions
Spinal Metastasis
Interventions
IORT with Kyphoplasty, Intrabeam®
Radiation · Device
Lead sponsor
Loyola University
Other
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting No phase listed Observational

A Registry of Intra-Operative Radiation Therapy (IORT) Using the Xoft ® Axxent ® eBx ™ System Patients

NCT03561454
View directory record Official record
Conditions
Early Stage Breast Cancer
Interventions
IORT
Device
Lead sponsor
MedStar Franklin Square Medical Center
Other
Eligibility
40 Years to 100 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Kypho-Intra Operative Radiation Therapy (IORT) for Localized Spine Metastasis, Phase I/II Study

NCT02987153
View directory record Official record
Conditions
Spinal Metastases
Interventions
Kypho-IORT
Radiation
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Efficacy of IORT With CT-Guided HDR Brachytherapy for Treatment of Breast Cancer

NCT02400658
View directory record Official record
Conditions
Breast Cancer
Interventions
IORT with CT-Guided HDR Brachytherapy
Device
Lead sponsor
Shayna Showalter, MD
Other
Eligibility
45 Years and older · Female only
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
3
States / cities
Hackensack, New Jersey • Philadelphia, Pennsylvania • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Sep 16, 2026, 2:13 PM EDT
Not listed Phase 1 Interventional

Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer

NCT02977468
View directory record Official record
Conditions
Triple Negative Breast Cancer
Interventions
Merck 3475 Pembrolizumab, Intraoperative radiation therapy (IORT)
Drug · Radiation
Lead sponsor
Eileen Connolly
Other
Eligibility
21 Years to 80 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
3
States / cities
Atlanta, Georgia • Maywood, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting No phase listed Observational

IORT-Breast at Medical Center Navicent Health

NCT04595435
View directory record Official record
Conditions
Breast Cancer Female, Early-stage Breast Cancer
Interventions
Lumpectomy, Intraoperative Radiation Therapy
Procedure · Radiation
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years and older · Female only
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2033
U.S. locations
1
States / cities
Macon, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Early Phase 1 Interventional

Combination Chemotherapy in Treating Patients With Sarcoma

NCT00662233
View directory record Official record
Conditions
Ovarian Cancer, Sarcoma
Interventions
cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, vincristine sulfate, adjuvant therapy, neoadjuvant therapy, therapeutic conventional surgery, brachytherapy, intraoperative radiation therapy, radiation therapy
Drug · Procedure · Radiation
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 21 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1991 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2018 · Synced Sep 16, 2026, 2:13 PM EDT
Recruiting No phase listed Observational

Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

NCT04603209
View directory record Official record
Conditions
Early-stage Breast Cancer, Breast Carcinoma in Situ, Breast Neoplasms
Interventions
Intraoperative Radiation Therapy (IORT)
Radiation
Lead sponsor
Saint John's Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Phase 1 Interventional

Intraoperative Radiation Therapy for Locally Advanced or Recurrent Abdomino-pelvic Solid Tumors With the CivaSheet

NCT02902107
View directory record Official record
Conditions
Abdominal Malignancy, Pelvic Malignancy
Interventions
CivaSheet, Brachytherapy, surgical resection
Device · Radiation · Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting Phase 4 Interventional

Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®

NCT04033081
View directory record Official record
Conditions
Sarcoma
Interventions
CivaSheet
Device
Lead sponsor
CivaTech Oncology
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Recruiting No phase listed Observational

Intra-Operative Radiation Registry

NCT04994067
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2032
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement

NCT03716531
View directory record Official record
Conditions
Pancreas Cancer
Interventions
IORT
Radiation
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
6
States / cities
Irvine, California • Jacksonville, Florida • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Quadrant High Dose Rate Intraoperative Radiation Therapy (IORT) for Early-Stage Breast Cancer: A Pilot Study

NCT00595062
View directory record Official record
Conditions
Breast Cancer
Interventions
Intra Operative Radiation Therapy (IORT)
Radiation
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
60 Years and older · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2015 · Synced Sep 16, 2026, 2:13 PM EDT
Not listed Phase 1 Interventional

Intraoperative Radiation Therapy for Resectable Pancreas Cancer

NCT02599662
View directory record Official record
Conditions
Pancreas Cancer
Interventions
10 Gy Low-KV IORT, 15 Gy Low-KV IORT, 20 GY Low-KV IORT
Radiation
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery

NCT01570998
View directory record Official record
Conditions
Stage IA Breast Cancer, Stage IIA Breast Cancer
Interventions
Intraoperative Radiation Therapy, Laboratory Biomarker Analysis
Radiation · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
45 Years and older · Female only
Enrollment
1,259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2028
U.S. locations
25
States / cities
Berkeley, California • Irvine, California • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 16, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System®

NCT01644669
View directory record Official record
Conditions
Invasive Ductal Carcinoma, Ductal Carcinoma in Situ
Interventions
Intra-operative Radiation Therapy - IORT
Radiation
Lead sponsor
Xoft, Inc.
Industry
Eligibility
40 Years and older · Female only
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2029
U.S. locations
22
States / cities
Tucson, Arizona • Duarte, California • Long Beach, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Sep 16, 2026, 2:13 PM EDT
Withdrawn Phase 2 Interventional

Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

NCT00017160
View directory record Official record
Conditions
Stage III Adult Soft Tissue Sarcoma, Recurrent Adult Soft Tissue Sarcoma, Stage IVA Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma, Stage IIC Adult Soft Tissue Sarcoma
Interventions
doxorubicin, filgrastim, ifosfamide, biological response modifier therapy, brachytherapy, chemotherapy, colony-stimulating factor therapy, conventional surgery, cytokine therapy, intraoperative radiotherapy, radiation therapy, surgery
Drug · Procedure
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
216
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 165 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2013 · Synced Sep 16, 2026, 2:13 PM EDT
Not listed Not applicable Interventional

Intraoperative Boost Radiotherapy With Electrons (IOERT) Followed By Hypofractionated Whole-Breast Irradiation (WBRT)

NCT01295723
View directory record Official record
Conditions
Invasive Lobular and Ductal Carcinoma
Interventions
Hypofractionated Whole Breast Radiation Therapy, Intraoperative Electron Radiation Therapy
Radiation
Lead sponsor
St. Joseph Hospital of Orange
Other
Eligibility
40 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2022
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 16, 2026, 2:13 PM EDT
Terminated Not applicable Interventional

Multi-Modality Therapy for Untreated Patients With Resectable or Marginally Resectable Pancreatic Cancer

NCT01760694
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
Multi-Modality; IORT, Surgery, Radiation, Chemotherapy
Other
Lead sponsor
Southwestern Regional Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 14, 2014 · Synced Sep 16, 2026, 2:13 PM EDT