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ClinicalTrials.gov public records Last synced Nov 13, 2026, 4:19 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 865–888 of 1,141 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Isotonic solution Clear all

Conditions: Diabetes
Interventions: slow fluid rate, fast fluid rate; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 1 Day to 18 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Healthy, Alzheimer Disease
Interventions: AL003, Saline Solution; Biological · Other
Lead sponsor: Alector Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 5
States / cities: Delray Beach, Florida • Lady Lake, Florida • Orlando, Florida + 2 more

Conditions: Genital Herpes, HSV-2 Infection
Interventions: GEN-003, Matrix-M2, 0.9% normal saline; Biological · Other
Lead sponsor: Genocea Biosciences, Inc.; Industry
Eligibility: Not listed
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 8
States / cities: Birmingham, Alabama • San Diego, California • San Francisco, California + 5 more

Conditions: Schizophrenia, Psychotic Disorders
Interventions: Tocilizumab, Normal saline; Drug
Lead sponsor: Brian Miller; Other
Eligibility: 18 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Stroke
Interventions: Botox®, saline solution; Other
Lead sponsor: New York Presbyterian Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Microvascular Coronary Artery Disease
Interventions: CLBS16, Placebo; Biological
Lead sponsor: Lisata Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 7
States / cities: Los Angeles, California • Gainesville, Florida • Hollywood, Florida + 4 more

Conditions: Autoimmune Epilepsy
Interventions: Intravenous Immunoglobulin, Placebos, Normal Saline; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Obesity, Hypertension
Interventions: Angiotensin-(1-7), Saline; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Intermittent Claudication
Interventions: Trans sodium crocetinate (TSC), 0.9% normal saline; Drug
Lead sponsor: Diffusion Pharmaceuticals Inc; Industry
Eligibility: 40 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 7
States / cities: Birmingham, Alabama • Santa Rosa, California • Stanford, California + 4 more

Conditions: Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
Interventions: Ropivacaine injection, normal saline; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: Up to 18 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 4
States / cities: Los Angeles, California • Santa Monica, California • Chicago, Illinois

Conditions: Heart Diseases, Left Ventricular Dysfunction
Interventions: Estradiol patch, Cetrotide, Fasting, Lower Body Negative Pressure; Drug · Other
Lead sponsor: The University of Texas at Arlington; Other
Eligibility: 18 Years to 30 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Arlington, Texas

Conditions: Healthy Volunteers
Interventions: Efprezimod alfa, Saline; Biological · Drug
Lead sponsor: Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA); Industry
Eligibility: 18 Years to 55 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Cardiac Arrest
Interventions: Thiamine 500 mg IV, Placebo; Drug · Other
Lead sponsor: Michael Donnino; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Thalassemia
Interventions: Luspatercept, Placebo, Best Supportive Care (BSC); Drug · Other
Lead sponsor: Celgene; Industry
Eligibility: 18 Years and older
Enrollment: 145 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 4
States / cities: Los Angeles, California • Oakland, California • Chicago, Illinois

Conditions: Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
Interventions: Dexmedetomidine, 0.9% Saline; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Intraventricular Hemorrhage
Interventions: Alteplase, Normal saline; Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 52
States / cities: Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 39 more

Conditions: Heterozygous Familial Hypercholesterolemia, Elevated Cholesterol
Interventions: Inclisiran, Placebo; Drug
Lead sponsor: The Medicines Company; Industry
Eligibility: 18 Years and older
Enrollment: 482 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 10
States / cities: Mission Viejo, California • Newport Beach, California • Stanford, California + 7 more

Conditions: Safety and Tolerability in Healthy Volunteers
Interventions: NLY01; Drug
Lead sponsor: Neuraly, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Middle-aged Adults, Major Depressive Disorder
Interventions: MitoTempol, Lactated Ringer's (control); Drug
Lead sponsor: University of Delaware; Other
Eligibility: 40 Years to 55 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Traumatic Brain Injury (TBI) Patients
Interventions: Normal Saline (0.9% NaCl), balanced crystalloid; Drug
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Chronic Migraine, Headache, Episodic Migraine
Interventions: Lidocaine 4% Topical Application Cream [LMX 4], Lidocaine Hydrochloride 2 mg/mL Injectable Solution, Normal Saline; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 7 Years to 21 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Migraine Headache
Interventions: Normal saline (1000 mL), Control; Other
Lead sponsor: Cooper Norcross Health; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Large Polyps in the Gastrointestinal Tract
Interventions: Autologous blood injection, Normal saline, HPMC; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Critical Illness, Acute Kidney Injury
Interventions: 0.9% Saline, Physiologically-balanced isotonic crystalloid; Other
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 5,381 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Nashville, Tennessee

Search by objective public record fields.

Fluid Resuscitation for Pediatric Diabetic Ketoacidosis

First in Human Study for Safety and Tolerability of AL003.

Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection

Tocilizumab in Schizophrenia

The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke

A Placebo-Controlled Trial of CLBS16 in Subjects With Coronary Microvascular Dysfunction

IVIG in Patients With VGKC Ab Associated Autoimmune Epilepsy

Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension

Safety, Efficacy, and Pharmacokinetics (PK) Study of Trans Sodium Crocetinate (TSC) in Patients With Intermittent Claudication

Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy

Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction

Safety Study of Efprezimod Alfa (CD24Fc, MK-7110) When Administered Intravenously in Healthy Adult Subjects (MK-7110-001)

Thiamine as a Metabolic Resuscitator After Cardiac Arrest

A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia

Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion

Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH)

A Phase 1 Study to Assess the Safety of NLY01 in Healthy Subjects

Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline

Saline Versus Balanced Crystalloid in Traumatic Brain Injury

Occipital Blocks for Acute Migraine

Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache

Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection

Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit