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ClinicalTrials.gov public records Last synced Oct 15, 2026, 11:39 AM EDT

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Showing 361–384 of 865 matching trials from the live ClinicalTrials.gov search.
Terminated No phase listed Observational

Study of the ConforMIS iDuo(R) G2

NCT01564641
Conditions
Bicompartmental Osteoarthritis
Interventions
iDuo G2
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
3
States / cities
New Castle, Indiana • New Orleans, Louisiana • Morrisville, Vermont
Conditions
Osteoarthritis, Overweight or Obesity
Interventions
Eloralintide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
39
States / cities
Mobile, Alabama • Mesa, Arizona • Phoenix, Arizona + 34 more
Conditions
Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
Interventions
GNSC-001, transient immune-modulation, Placebo
Genetic · Drug
Lead sponsor
Genascence Corporation
Industry
Eligibility
40 Years to 75 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
9
States / cities
Mobile, Alabama • La Mesa, California • San Diego, California + 6 more
Terminated No phase listed Observational Accepts healthy volunteers

Prospective Trial of the TriFit™ Web Knee Brace

NCT03633071
Conditions
Satisfaction
Interventions
Web-knee brace
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Not listed Not applicable Interventional

Impact of Sensor Technology in Knee OA

NCT05222503
Conditions
Knee Osteoarthritis
Interventions
Knee Brace + OPUM Digital Knee, Knee Brace
Device
Lead sponsor
OPUM Technologies US LTD
Other
Eligibility
40 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Osteoarthritis
Interventions
Diet, Exercise
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
55 Years and older
Enrollment
454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Knee Arthroplasty
Interventions
Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, RESTORIS Multicompartmental Knee System, Depuy Knee Replacement System, Stryker® Knee Replacement System
Procedure · Device
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Vancouver, Washington
Conditions
Knee Osteoarthristis
Interventions
Dephy Exoboot
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 100 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Knee Osteoarthritis
Interventions
Optimized Tai Chi intervention, Traditional Tai Chi intervention
Behavioral
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
40 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Osteoarthritis
Interventions
Modified Citrus Pectin, Placebo
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Strength Training on Knee Osteoarthritis

NCT00000406
Conditions
Osteoarthritis, Knee
Interventions
Progressive resistance exercise
Procedure
Lead sponsor
Indiana University
Other
Eligibility
60 Years and older
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1977 – 2006
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Osteoarthritis
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
40 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Not listed Not applicable Interventional Accepts healthy volunteers

Veteran Affairs Osteoarthritis Knee Study

NCT04698733
Conditions
Knee Osteoarthritis
Interventions
BEST™ HVPC microcurrent electrical stimulation Pro-Sport Ultra® device
Device
Lead sponsor
Avazzia, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
Interventions
Methylprednisolone 4 milligram Tab, Dexamethasone injection
Drug
Lead sponsor
F. Johannes Plate
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers

Long-Duration Ultrasound for Knee Osteoarthritis

NCT03800927
Conditions
Osteo Arthritis Knee
Interventions
Long duration ultrasound
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Stamford, Connecticut • Dryden, New York
Completed No phase listed Observational Accepts healthy volunteers

Pain Phenotypes in Knee Osteoarthritis

NCT02664896
Conditions
Osteoarthritis, Knee, Pain
Interventions
Knee Osteoarthritis, Healthy Control
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Completed Phase 3 Interventional Results available

Gel-200 Versus Placebo in Osteoarthritis of the Knee

NCT00449696
Conditions
Osteoarthritis of the Knee
Interventions
Gel-200, Placebo
Device
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
40 Years to 80 Years
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Plantation, Florida
Completed No phase listed Observational Accepts healthy volunteers

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003
Conditions
Total Knee Arthroplasty
Interventions
Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
1,694 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
9
States / cities
Aurora, Colorado • Gulf Breeze, Florida • Indianapolis, Indiana + 6 more
Conditions
Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
Interventions
Encore 3DKnee™ system, Encore MJS™ Knee System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fresno, California
Terminated No phase listed Observational Accepts healthy volunteers

Total Knee Arthroplasty Functional Outcomes Study Research Design

NCT02228538
Conditions
Osteoarthritis of the Knee
Interventions
Total knee arthroplasty patients
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
New Orleans, Louisiana
Completed Not applicable Interventional Results available

Telehealth Exercise and Mindfulness for Pain in Osteoarthritis

NCT05524116
Conditions
Knee Osteoarthritis
Interventions
Mindful Exercise program, Exercise
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
50 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Osteoarthritis of Knee, Osteoarthritis, Knee
Interventions
AMZ001 Diclofenac gel, Placebo gel
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
549 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
7
States / cities
Thousand Oaks, California • Hialeah, Florida • Longwood, Florida + 4 more
Conditions
Osteoarthritis, Knee
Interventions
Acellular amniotic membrane derived allograft injection (NuDYN)
Drug
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
21 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Westmont, Illinois
Conditions
Osteoarthritis, Pain
Interventions
Placebo, Fulranumab 1 mg, Fulranumab 3 mg, Opioid
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
36
States / cities
Birmingham, Alabama • Huntsville, Alabama • Cerritos, California + 33 more