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ClinicalTrials.gov public records Last synced Oct 17, 2026, 1:10 AM EDT

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Showing 697–720 of 865 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Knee Osteoarthritis Clear all
Completed No phase listed Observational Accepts healthy volunteers

Osteoarthritis Initiative (OAI): A Knee Health Study

NCT00080171
View directory record Official record
Conditions
Osteoarthritis, Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
45 Years to 79 Years
Enrollment
4,796 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2015
U.S. locations
5
States / cities
Baltimore, Maryland • Columbus, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2020 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

NCT01373099
View directory record Official record
Conditions
Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 17, 2026, 1:10 AM EDT
Completed No phase listed Observational

A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System

NCT03289000
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
iTotal Posterior Stabilized (PS) Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
2
States / cities
Nashville, Tennessee • Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 4 Interventional Results available

Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)

NCT01780389
View directory record Official record
Conditions
Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain
Interventions
Open-label flexibly dosed milnacipran
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2015 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 4 Interventional Results available

Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab

NCT01144143
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Infliximab, Placebo, Standard of Care: Methylprednisolone acetate
Drug
Lead sponsor
Herbert Lindsley, MD
Other
Eligibility
35 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2018 · Synced Oct 17, 2026, 1:10 AM EDT
Recruiting Not applicable Interventional

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

NCT05596591
View directory record Official record
Conditions
Bone Marrow Edema, Knee Osteoarthritis, Knee Pain Chronic
Interventions
Focused extracorporeal shockwave therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
30 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Cedar Knolls, New Jersey • West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Can Computer-based Telephone Counseling Improve Long-term Adherence to Strength Training in Elders With Knee OA?

NCT01394874
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
TLC
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Oct 17, 2026, 1:10 AM EDT
Active, not recruiting Not applicable Interventional

Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)

NCT03747393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
3
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

A Pilot Observational Clinical Survey: Impacts of Tahitian Noni Juice on the Quality of Life of Patients With Osteoarthritis

NCT01070264
View directory record Official record
Conditions
Osteoarthritis
Interventions
Noni Juice
Dietary Supplement
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
40 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Rockford, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 17, 2010 · Synced Oct 17, 2026, 1:10 AM EDT
Recruiting Not applicable Interventional

MISHA Post-Market Clinical Study

NCT06118892
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
MISHA Knee System
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
4
States / cities
Sonoma, California • Raleigh, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 3 Interventional

A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

NCT05931367
View directory record Official record
Conditions
Obesity, Overweight, Osteo Arthritis Knee
Interventions
Retatrutide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
445 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
13
States / cities
Phoenix, Arizona • San Diego, California • Waterbury, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 2 Interventional

A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee

NCT01366014
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ARRY-371797, p38 inhibitor; oral, Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral, Placebo; oral
Drug
Lead sponsor
Pfizer
Industry
Eligibility
40 Years to 85 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
13
States / cities
Phoenix, Arizona • Fort Lauderdale, Florida • Pinellas Park, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 4 Interventional

Combined Vibrations, Passive Motion and Thermotherapy for Knee Osteoarthritis

NCT00858416
View directory record Official record
Conditions
Osteoarthritis, Knee Pain
Interventions
"Kineticure System" followed by sham, sham followed by "Kineticure System"
Device
Lead sponsor
Kineticure
Industry
Eligibility
45 Years to 80 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 9, 2009 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 2 Interventional

A Long-Term Safety Study of IDEA-033 in Comparison to Oral Naproxen for the Treatment of Osteoarthritis of the Knee

NCT00265304
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ketoprofen
Drug
Lead sponsor
IDEA AG
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
93
States / cities
Birmingham, Alabama • Montgomery, Alabama • Northport, Alabama + 77 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2009 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 4 Interventional

TREAD-20 Extension - Treatment of Knee Pain Due to Osteoarthritis

NCT00830830
View directory record Official record
Conditions
Osteoarthritis
Interventions
Hyalgan (sodium hyaluronate)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
40 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 19, 2009 · Synced Oct 17, 2026, 1:10 AM EDT
Not listed Phase 2 Interventional

Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee

NCT03441607
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
mHACMb, placebo
Drug · Other
Lead sponsor
Applied Biologics, LLC
Industry
Eligibility
30 Years and older
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 17, 2026, 1:10 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)

NCT06463132
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
PEP/Euflexxa, PEP
Combination Product · Drug
Lead sponsor
Rion Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis

NCT02318511
View directory record Official record
Conditions
Osteoarthritis
Interventions
Knee injection, ReNu amniotic allograft, placebo saline, Hyaluronic Acid
Procedure · Other · Device
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
12
States / cities
Birmingham, Alabama • Los Angeles, California • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Mind-body Therapy (Remotely Delivered) for Knee Osteoarthritis

NCT04678999
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Mind-body exercise and education
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Aerobic Exercise Intervention for Knee Osteoarthritis

NCT00049816
View directory record Official record
Conditions
Osteoarthritis
Interventions
Walking exercise, Cycling Exercise
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 17, 2013 · Synced Oct 17, 2026, 1:10 AM EDT
Terminated Not applicable Interventional

Physical Therapy vs Remote Exercise for Knee Pain Due to Osteoarthritis (OA)

NCT06167304
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain
Interventions
Technology-implemented exercise therapy, Traditional Physical Therapy
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 17, 2026, 1:10 AM EDT
Completed No phase listed Observational Results available

A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis

NCT03257371
View directory record Official record
Conditions
Post-traumatic Osteoarthritis
Interventions
Not listed
Lead sponsor
James Stannard
Other
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee

NCT01404052
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 17, 2026, 1:10 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Civamide in OA of the Knee(s)

NCT00077935
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Civamide
Drug
Lead sponsor
Winston Laboratories
Industry
Eligibility
40 Years to 76 Years
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
34
States / cities
Birmingham, Alabama • Tucson, Arizona • Beverly Hills, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2011 · Synced Oct 17, 2026, 1:10 AM EDT