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ClinicalTrials.gov public records Last synced Oct 14, 2026, 9:56 PM EDT

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Showing 193–216 of 865 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Knee Osteoarthritis Clear all
Completed Phase 1 Interventional

Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA

NCT02790723
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
sc-rAAV2.5IL-1Ra
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis

NCT02905240
View directory record Official record
Conditions
Osteoarthritis
Interventions
nSTRIDE APS, Saline
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 80 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
27
States / cities
Birmingham, Alabama • Guntersville, Alabama • Tucson, Arizona + 24 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Terminated Not applicable Interventional Results available

Long-Term Effectiveness of Walking Training in Patients With Knee Osteoarthritis

NCT02767570
View directory record Official record
Conditions
Osteoarthritis
Interventions
Gait Training; Altered Foot Progression Angle, Gait Training; Consistent Foot Progression Angle
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee

NCT00755482
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Aquamin F, Placebo (maltodextran)
Drug
Lead sponsor
Marigot Ltd.
Industry
Eligibility
35 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2008 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee

NCT00504127
View directory record Official record
Conditions
Osteoarthritis
Interventions
Naproxcinod 375 mg bid, Naproxcinod 750 mg bid, Naproxen 500 mg bid, placebo
Drug
Lead sponsor
NicOx
Industry
Eligibility
40 Years and older
Enrollment
1,020 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
73
States / cities
Chandler, Arizona • Tempe, Arizona • Tucson, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2011 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 2 Interventional

Muscle Strengthening Device for Knee Osteoarthritis

NCT00007241
View directory record Official record
Conditions
Osteoarthritis
Interventions
Isometric exercise
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
6
States / cities
Trumbull, Connecticut • Moorestown, New Jersey • Rochester, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2007 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 4 Interventional

Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

NCT00194090
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
celecoxib
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
45 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Strength and Function Following Total Hip Arthroplasty

NCT01817010
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Multi-Component Rehabilitation (CMC), Control (CON)
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 14, 2026, 9:56 PM EDT
Withdrawn Not applicable Interventional

Knee Injections for the Clinical Management of Knee OsteoArthritis

NCT04595890
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Arthrex Angel System used to prepare injection of Bone Marrow Concentrate (BMC), Saline injection
Device · Other
Lead sponsor
University of Delaware
Other
Eligibility
40 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 3 Interventional

A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip

NCT02462850
View directory record Official record
Conditions
Pain, Nausea, Vomiting
Interventions
CL-108
Drug
Lead sponsor
Charleston Laboratories, Inc
Industry
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Oct 14, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

NCT04472702
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
cRFA
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
35 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Sacramento, California • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 14, 2026, 9:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
1,694 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
9
States / cities
Aurora, Colorado • Gulf Breeze, Florida • Indianapolis, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 3 Interventional Results available

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

NCT03304379
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Fasinumab, Diclofenac, Celecoxib, Matching placebo
Drug · Other
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
1,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
71
States / cities
Anniston, Alabama • Mobile, Alabama • Chandler, Arizona + 63 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional

ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial

NCT05765266
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
ACP Max™, Depo-Medrol®
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Winston-Salem, North Carolina • Knoxville, Tennessee • Danville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 14, 2026, 9:56 PM EDT
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 14, 2026, 9:56 PM EDT
Completed No phase listed Observational

Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip

NCT00105677
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Degenerative, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years to 79 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Pittsburgh, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 14, 2026, 9:56 PM EDT
Completed No phase listed Observational

How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)

NCT04020471
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
Interventions
Pain Scale/Medication Log
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Early Phase 1 Interventional

Pilot Synovial Fluid Molecular/Stem Cell Response to PRP in Knee Osteoarthritis: Clinical & Imaging Outcome Correlation

NCT02468492
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Platelet Rich Plasma, Normal Saline
Biological · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis

NCT02588872
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Platelet-rich Plasma (PRP), Hyaluronic Acid
Biological
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Not listed Not applicable Interventional

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

NCT03014401
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
35 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
3
States / cities
Santa Monica, California • Stanford, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Total Knee Arthroplasty Biomechanics

NCT03671954
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
4
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of RHH646 for Knee Osteoarthritis

NCT05816395
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
RHH646, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
35 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Lincoln, California • Winter Park, Florida • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 14, 2026, 9:56 PM EDT
Completed No phase listed Observational

Safety and Efficacy of the Journey II BCS Total Knee System

NCT01705067
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TKA with Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
12
States / cities
Los Angeles, California • Fort Wayne, Indiana • Indianapolis, Indiana + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Oct 14, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis

NCT02350387
View directory record Official record
Conditions
Osteoarthritis
Interventions
High Intensity Short Duration Exercise, Low intensity Long Duration Exercise
Procedure
Lead sponsor
Regis University
Other
Eligibility
55 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 26, 2016 · Synced Oct 14, 2026, 9:56 PM EDT