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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: L-Isoleucine Clear all

Conditions: Hereditary Transthyretin-mediated (ATTRv) Amyloidosis, Polyneuropathy
Interventions: Patisiran; Drug
Lead sponsor: Alnylam Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 27
States / cities: Los Angeles, California • San Diego, California • Aurora, Colorado + 22 more

Conditions: Type 2 Diabetes, Healthy Individuals
Interventions: Branched Chained Amino Acids, Cellulose Placebo mix; Dietary Supplement · Other
Lead sponsor: Loma Linda University; Other
Eligibility: 20 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Cirrhosis
Interventions: BCAA Supplement, Physical Activity; Dietary Supplement · Other
Lead sponsor: Loyola University; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Chronic Obstructive Pulmonary Disease
Interventions: acute resistance exercise with oral nutrition supplementation, stable tracer infusion; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 45 Years to 100 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Traumatic Brain Injury
Interventions: Branched Chain Amino Acids, Protein Control; Dietary Supplement
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Breast Cancer
Interventions: Acute tryptophan depletion, Half-strength tryptophan depletion (Control); Dietary Supplement
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Non Alcoholic Steatohepatitis (NASH)
Interventions: AXA1125, Placebo; Drug
Lead sponsor: Axcella Health, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 273 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 57
States / cities: Cullman, Alabama • Tucson, Arizona • Canoga Park, California + 45 more

Conditions: Healthy
Interventions: Branched Chain Amino Acids, Placebo; Dietary Supplement · Other
Lead sponsor: Montana State University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Bozeman, Montana

Conditions: Muscle Atrophy, Quality of Life
Interventions: Essential Amino Acids (EAA), Placebo (Alanine); Drug
Lead sponsor: University of Oregon; Other
Eligibility: 50 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Dietary Intake of Branched Chain Amino Acids
Interventions: Diet high in amino acid levels, Diet low in amino acid levels; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 20 Years to 40 Years · Male only
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: NAFLD
Interventions: AXA1957, AXA1125, Placebo; Dietary Supplement
Lead sponsor: Axcella Health, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 18
States / cities: Chandler, Arizona • Tucson, Arizona • Huntington Park, California + 14 more

Conditions: Obesity, Diabetes
Interventions: Control diet, Low branched-chain amino acids(BCAA) diet, Low protein diet; Dietary Supplement
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 30 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Type 2 Diabetes
Interventions: Oral Supplement, Placebo; Dietary Supplement
Lead sponsor: Texas A&M University; Other
Eligibility: 45 Years to 84 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Metabolic-dysfunction Associated Steatotic Liver Disease
Interventions: Essential Amino Acids Supplementation intervention, Low sugar diet; Drug · Other
Lead sponsor: Michigan State University; Other
Eligibility: 11 Years to 17 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Grand Rapids, Michigan

Conditions: Menopause
Interventions: estrogen patch, Amino acids, Placebo Patch, Placebo pills; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 48 Years to 60 Years · Female only
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Eyelash Growth
Interventions: DIME Beauty Eyelash Boost Serum; Other
Lead sponsor: Dime Beauty Co.; Industry
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: stable amino acid infusion, acute exercise with amino acid infusion, 24-hour post exercise amino acid infusion; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 45 Years and older
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Protein Metabolism
Interventions: Total Amino Acids, Essential Amino Acids, Essential Amino Acids + Hydroxy-methylbutyric acid (HMB), Essential Amino Acids + Leucine, Essential Amino Acids High, Placebo Water; Dietary Supplement
Lead sponsor: Texas A&M University; Other
Eligibility: 60 Years to 80 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Osteoarthritis
Interventions: Essential amino acids, Alanine; Dietary Supplement
Lead sponsor: University of Oregon; Other
Eligibility: 60 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
Interventions: L-Isoleucine, Low-isoleucine diet; Dietary Supplement · Other
Lead sponsor: Jean L. Fry; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Lumbar Spinal Stenosis
Interventions: Essential amino acids, Alanine; Dietary Supplement
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Orange, California

Search by objective public record fields.

A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation

The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients

BCAA Supplemental Study

Oral Supplement and Acute Resistance Exercise

SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI

The Role of Serotonin in Hot Flashes After Breast Cancer

Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis

Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise

Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults

Dietary Intake and Circulating Levels of Branched Chain Amino Acids

Study of the Safety and Tolerability of AXA1125 and AXA1957 in Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)

SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids

Isoleucine Intake and Intermediary Metabolism in Type 2 Diabetes

SMART Diets for MASLD

Estrogen and Serotonin on Changing Brain Chemistry

A Single-Group Study to Evaluate the Effects of an Eyelash Serum on Improving Eyelash Growth

Chronic Obstructive Pulmonary Disorder and Acute Exercise

Prandial Metabolic Phenotype in Adults

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

Isoleucine Addition Treatment Effects in a Controlled Diet Study

Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial