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ClinicalTrials.gov public records Last synced Nov 5, 2026, 3:38 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: L-Leucine Clear all

Conditions: Gastroenteritis Escherichia Coli, Immunisation
Interventions: Placebo, Recombinant Double Mutant Heat-Labile Toxin LT(R192G/L211A) (dmLT) Oral enterotoxigenic Escherichia coli (ETEC) Vaccine; Other · Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 45 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Schizophrenia
Interventions: N-acetylcysteine (NAC), Inactive placebo capsule; Drug
Lead sponsor: VA Greater Los Angeles Healthcare System; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Prematurity, Necrotizing Enterocolitis
Interventions: [5,5,5-2H3]leucine (stable isotope labeled leucine); Biological
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 1 Day to 7 Days
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Osteoarthritis
Interventions: Essential amino acids, Alanine; Dietary Supplement
Lead sponsor: University of Oregon; Other
Eligibility: 60 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Alzheimer Disease
Interventions: LY450139, placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 21 Years to 50 Years · Male only
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Obesity, Menopause, Osteoporosis, Sarcopenia
Interventions: Weight loss with normal protein and leucine intake, Weight loss with protein/leucine supplementation; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 50 Years to 65 Years · Female only
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Solid Tumors, Sarcomas
Interventions: ZL-6201; Drug
Lead sponsor: Zai Lab (Shanghai) Co., Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 6
States / cities: Los Angeles, California • New Haven, Connecticut • Sarasota, Florida + 3 more

Conditions: Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection, Low Anterior Resection Syndrome
Interventions: Patient Activation Booklet and nursing support for patients with LARS; Other
Lead sponsor: Jewish General Hospital; Other
Eligibility: 18 Years to 99 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Carcinoma, Non-small-Cell Lung
Interventions: Amivantamab, Lazertinib, Carboplatin, Pemetrexed, Direct Oral Anticoagulant (DOAC), Low Molecular Weight Heparin (LMWH); Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 520 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 26
States / cities: La Jolla, California • Orange, California • Stanford, California + 21 more

Conditions: Vitamin B6 Deficiency
Interventions: Arm 1 glycine and leucine, Arm 2 Intervention of Serine and methionine infusion; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 20 Years to 40 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis
Interventions: Satralizumab, Placebo; Drug · Other
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 12 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 11
States / cities: Birmingham, Alabama • Newport Beach, California • San Francisco, California + 7 more

Conditions: Branched-chain Amino Acid Metabolism, Insulin Sensitivity
Interventions: Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training, GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery; Other
Lead sponsor: Duke University; Other
Eligibility: 30 Years to 65 Years
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Chronic Obstructive Pulmonary Disease
Interventions: Casein protein hydrolysates, Whey protein hydrolysates, Casein protein hydrolysates + LEU, Whey protein hydrolysates + LEU; Dietary Supplement
Lead sponsor: Texas A&M University; Other
Eligibility: 45 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Hypertrophy, Strength Training Adaptations, Weight-Bearing Strengthening Program
Interventions: Placebo, Leucine, Dileucine; Dietary Supplement
Lead sponsor: Lindenwood University; Other
Eligibility: 18 Years to 39 Years · Male only
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Saint Charles, Missouri

Conditions: Pancreatitis, Graft, Pancreatic Transplant Post-Transplant Dysfunction Rejection
Interventions: 18F-fluciclovine; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: ACL Reconstruction
Interventions: Whey protein isolate, Protein + BAA, Placebo; Dietary Supplement
Lead sponsor: The Methodist Hospital Research Institute; Other
Eligibility: 16 Years to 40 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Muscle Loss, Muscle Anabolism
Interventions: Essential Amino Acids, Endurance exercise; Dietary Supplement · Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 18 Years to 35 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Boston, Massachusetts • Natick, Massachusetts

Conditions: Healthy
Interventions: Dichloroacetate, Genotyping, Leucine, tyrosine; Drug · Genetic · Other
Lead sponsor: University of Florida; Other
Eligibility: 22 Years to 60 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Type 2 Diabetes Mellitus
Interventions: Low Metformin, Metformin, Mid Metformin, High Metformin; Drug
Lead sponsor: NuSirt Biopharma; Industry
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 9
States / cities: Chino, California • Palm Beach, Florida • Tampa, Florida + 5 more

Conditions: Infant, Low Birth Weight, Hyperglycemia
Interventions: alanine, amino acids, glucagon, glucose, glutamine, glycerol, insulin, leucine, lipids, urea; Drug
Lead sponsor: National Center for Research Resources (NCRR); NIH
Eligibility: 4 Days to 6 Days
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1999
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Brain Mapping
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 28 Years
Enrollment: 538 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2017
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Bed Rest
Interventions: Leucine, Exercise, Whey protein; Dietary Supplement · Behavioral
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 60 Years to 80 Years
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Prostate Cancer
Interventions: Sargramostim (GM-CSF, Leukine), Flutamide (Eulexin), PROSTVAC-F/ TRICOM, PROSTVAC-V/TRICOM; Drug · Biological
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years to 110 Years · Male only
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2017
U.S. locations: 3
States / cities: Bethesda, Maryland • New Brunswick, New Jersey • Philadelphia, Pennsylvania

Conditions: Aging
Interventions: Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine, 4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides, 6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline, Water control; Behavioral · Dietary Supplement · Other
Lead sponsor: University of Illinois at Urbana-Champaign; Other
Eligibility: 20 Years to 79 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Urbana, Illinois

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A Double-Blind Placebo-Control Dose Escalating Study to Evaluate the Safety and Immunogenicity of dmLT by Oral, Sublingual and Intradermal Vaccination in Adults Residing in an Endemic Area

N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia

Collaborative Research Group for Necrotizing Enterocolitis

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response.

Calorie Restriction With Leucine Supplementation

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Vitamin B6 Dependence of One-Carbon Metabolism

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes

Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients

Dileucine and Resistance Training Adaptations

18F-Fluciclovine PET/CT in the Assessment of Pancreatic Transplants

Protein Supplementation After ACL Surgery

Essential Amino Acids Supplementation and Muscle Protein Synthesis

Pharmacotoxicology of Trichloroethylene Metabolites

Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients

Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion

Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation

Preserving Muscle Mass and Function in Bedridden Older Adults

Vaccine Therapy With PROSTVAC/TRICOM and Flutamide Versus Flutamide Alone to Treat Prostate Cancer

Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women