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ClinicalTrials.gov public records Last synced Sep 19, 2026, 11:44 AM EDT

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Showing 1–24 of 106 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: L-Leucine Clear all
Completed Not applicable Interventional Accepts healthy volunteers

High Quality Protein for Assisting With Weight Loss

NCT03085511
View directory record Official record
Conditions
Obesity
Interventions
Egg breakfast (EB), Weight Loss Counseling, Weight Loss Diet, Cereal Breakfast (CB)
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Sep 19, 2026, 11:44 AM EDT
Recruiting Phase 2 Interventional

Essential Amino Acid Supplementation for Femoral Fragility Fractures

NCT06050668
View directory record Official record
Conditions
Femoral Fracture, Fragility Fracture, Muscle Atrophy
Interventions
Essential Amino Acid Supplementation
Combination Product
Lead sponsor
Michael C Willey
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Iowa City, Iowa • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Leucine on Body Weight

NCT00683826
View directory record Official record
Conditions
Overweight, Obesity
Interventions
L-Leucine 8gr, Liquid meal, L-Leucine 4g
Dietary Supplement · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 4, 2013 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional

EAA Intake to Optimize Protein Anabolism in COPD

NCT01173354
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Free balanced amino acid mixture, Free essential amino acid mixture
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
45 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional

Resveratrol-Leucine Metabolite Synergy in Pre-diabetes

NCT01593605
View directory record Official record
Conditions
Impaired Glucose Tolerance
Interventions
Resveratrol, resveratrol /HMB, Placebo treatment
Dietary Supplement · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 19, 2013 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Research Study to Determine if an Experimental Agent, LLME Can Decrease the Incidence and Severity of Graft-Versus-Host-Disease (GVHD) Following Blood (Hematopoietic) Stem Cell Transplantation

NCT00429416
View directory record Official record
Conditions
Hematologic Malignancies
Interventions
L-leucyl-L-leucine Methyl Ester (LLME), Fludarabine, Cytarabine, Cyclophosphamide, Tacrolimus, Mesna, Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF), Hematopoietic stem cell transplantation (HSCT)
Drug · Biological · Procedure
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2016 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Microbial Protease Supplementation on Postprandial Amino Acid Levels

NCT04821557
View directory record Official record
Conditions
Protein Metabolism
Interventions
Protease + Protein, Placebo + Protein
Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
20 Years to 50 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 4, 2024 · Synced Sep 19, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

NCT03208868
View directory record Official record
Conditions
Cirrhosis, Liver
Interventions
Leucine enriched essential amino acid (EEA/LEU), Balanced amino acid supplement (BAA)
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional

SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI

NCT04603443
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Branched Chain Amino Acids, Protein Control
Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Completed No phase listed Observational

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

NCT01536821
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
9
States / cities
Weston, Florida • Indianapolis, Indiana • Iowa City, Iowa + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2013 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise

NCT04969536
View directory record Official record
Conditions
Healthy
Interventions
Branched Chain Amino Acids, Placebo
Dietary Supplement · Other
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Results available

Study of the Safety and Tolerability of AXA1125 and AXA1957 in Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)

NCT04073368
View directory record Official record
Conditions
NAFLD
Interventions
AXA1957, AXA1125, Placebo
Dietary Supplement
Lead sponsor
Axcella Health, Inc
Industry
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
18
States / cities
Chandler, Arizona • Tucson, Arizona • Huntington Park, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2021 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women

NCT02918981
View directory record Official record
Conditions
Aging
Interventions
Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine, 4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides, 6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline, Water control
Behavioral · Dietary Supplement · Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
20 Years to 79 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)

NCT01734473
View directory record Official record
Conditions
COPD
Interventions
Hydrolyzed casein protein, Hydrolyzed casein protein + carbohydrates, Hydrolyzed casein protein + leucine, Hydrolyzed casein protein + carbohydrates + leucine, 4 levels of hydrolyzed casein protein + carbohydrates
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
45 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides

NCT03952884
View directory record Official record
Conditions
Protein Metabolism
Interventions
Resistance Exercise, No Resistance Exercise, Leucine, Dileucine
Behavioral · Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 2 Interventional Results available

Vaccine Therapy With PROSTVAC/TRICOM and Flutamide Versus Flutamide Alone to Treat Prostate Cancer

NCT00450463
View directory record Official record
Conditions
Prostate Cancer
Interventions
Sargramostim (GM-CSF, Leukine), Flutamide (Eulexin), PROSTVAC-F/ TRICOM, PROSTVAC-V/TRICOM
Drug · Biological
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 110 Years · Male only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2017
U.S. locations
3
States / cities
Bethesda, Maryland • New Brunswick, New Jersey • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 1 Interventional

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB094 in Adults With Parkinson's Disease

NCT03976349
View directory record Official record
Conditions
Parkinson's Disease
Interventions
BIIB094, Placebo
Drug
Lead sponsor
Ionis Pharmaceuticals, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
7
States / cities
Chicago, Illinois • Farmington Hills, Michigan • Cleveland, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

NCT01005862
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
PF-04360365, Placebo
Biological · Drug
Lead sponsor
Pfizer
Industry
Eligibility
21 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Glendale, California • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 25, 2012 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Investigate the Relative Bioavailability of AZD8630 Following a Device and Formulation Transition in Healthy Participants.

NCT06531811
View directory record Official record
Conditions
Healthy Participants
Interventions
AZD8630 (test formulation) via test inhaler, AZD8630 (reference formulation) via Monodose inhaler, Test inhaler, Monodose inhaler
Drug · Device
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 19, 2026, 11:44 AM EDT
Recruiting Phase 2 Interventional

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

NCT06680830
View directory record Official record
Conditions
Parkinson Disease, Parkinson, Idiopathic Parkinson Disease, Early Parkinson Disease (Early PD), Parkinson Disease, Idiopathic
Interventions
NEU-411, Placebo
Drug · Other
Lead sponsor
Neuron23 Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
45
States / cities
Sun City, Arizona • Little Rock, Arkansas • Fresno, California + 40 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Not applicable Interventional Results available

The Role of Serotonin in Hot Flashes After Breast Cancer

NCT00228943
View directory record Official record
Conditions
Breast Cancer
Interventions
Acute tryptophan depletion, Half-strength tryptophan depletion (Control)
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Sep 19, 2026, 11:44 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Leucine, mTOR and Athero

NCT05470218
View directory record Official record
Conditions
Atherosclerosis
Interventions
Meal
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

High Protein Diet and Atherosclerosis

NCT05235464
View directory record Official record
Conditions
Atherosclerosis
Interventions
Standard meal, High animal protein meal, High plant protein meal, High plant protein meal with additional leucine
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
45 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 19, 2026, 11:44 AM EDT
Completed Phase 2 Interventional Results available

N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC)

NCT03759639
View directory record Official record
Conditions
Niemann-Pick Disease, Type C
Interventions
IB1001
Drug
Lead sponsor
IntraBio Inc
Industry
Eligibility
6 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 19, 2026, 11:44 AM EDT