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ClinicalTrials.gov public records Last synced Oct 2, 2026, 5:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 84 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: L-thyroxine (L-T4) Clear all
Not yet recruiting Phase 4 Interventional

Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism

NCT07787585
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine Pill, Placebo
Drug
Lead sponsor
Spyridoula Maraka
Other
Eligibility
65 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
3
States / cities
Little Rock, Arkansas • Gainesville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 3 Interventional

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.

NCT00158990
View directory record Official record
Conditions
Major Depression, Bipolar Disorder, Unipolar Depression
Interventions
triiodothyronine, sertraline
Drug
Lead sponsor
Hadassah Medical Organization
Other
Eligibility
18 Years to 70 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 4, 2007 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Developing Oral LT3 Therapy for Heart Failure - HFpEF

NCT04111536
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Low Triiodothyronine Syndrome
Interventions
liothyronine, Placebo
Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 4 Interventional Results available

Neurocognitive and Metabolic Effects of Mild Hypothyroidism

NCT00565864
View directory record Official record
Conditions
Hypothyroidism
Interventions
L-thyroxine (L-T4)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
20 Years to 75 Years
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 22, 2018 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 3 Interventional Results available

Intravenous Thyroxine for Heart-Eligible Organ Donors

NCT04415658
View directory record Official record
Conditions
Brain Death, Heart Failure
Interventions
Thyroxine, Saline
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
14 Years to 55 Years
Enrollment
838 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
14
States / cities
Phoenix, Arizona • San Diego, California • Denver, Colorado + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2024 · Synced Oct 2, 2026, 5:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Thyroid Measures and Mood

NCT00565032
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Not applicable Interventional Results available

Thyroid Hormone Dose Adjustment in Pregnancy

NCT00230802
View directory record Official record
Conditions
Pregnancy, Hypothyroidism
Interventions
Anticipatory dose increase of levothyroxine, levothyroxine
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 23, 2016 · Synced Oct 2, 2026, 5:17 AM EDT
Not yet recruiting Phase 2 Interventional

T4/T3 Therapy in Hypothyroidism

NCT07424183
View directory record Official record
Conditions
Hypothyroidism Primary
Interventions
Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg

NCT00648700
View directory record Official record
Conditions
Healthy
Interventions
Levothyroxine Sodium Tablets 300 μg, Levothroid® Tablets 300 μg
Drug
Lead sponsor
Mylan Pharmaceuticals Inc
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 2, 2026, 5:17 AM EDT
Not listed Not applicable Interventional

Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment

NCT01739972
View directory record Official record
Conditions
Primary Hypothyroidism.
Interventions
Levothyroxine, Desiccated thyroid extract
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Generic vs. Name-Brand Levothyroxine

NCT00403390
View directory record Official record
Conditions
Congenital Hypothyroidism, Hypothyroidism
Interventions
Brand Name Levothyroxine (Synthroid), Generic formulation of Levothyroxine
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 18 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 2, 2026, 5:17 AM EDT
Terminated No phase listed Observational

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

NCT02567877
View directory record Official record
Conditions
Postsurgical Hypothyroidism, Hypothyroidism
Interventions
thyroidectomy, levothyroxine in thyroidectomy patients
Procedure · Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 2, 2026, 5:17 AM EDT
Withdrawn Phase 4 Interventional

Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding

NCT02577367
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine
Drug
Lead sponsor
Jocelyne Karam
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)

NCT06625814
View directory record Official record
Conditions
Healthy
Interventions
Levothyroxine, Enlicitide Decanoate
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
19 Years to 50 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

NCT03098433
View directory record Official record
Conditions
Healthy
Interventions
Liothyronine, Levothyroxine, Placebos
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2021 · Synced Oct 2, 2026, 5:17 AM EDT
Recruiting Phase 2Phase 3 Interventional

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

NCT06345339
View directory record Official record
Conditions
Hypothyroidism
Interventions
Armour Thyroid, Levothyroxine
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 75 Years
Enrollment
2,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
134
States / cities
Birmingham, Alabama • Bonita, California • Burbank, California + 109 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Fasting Study of Levothyroxine Sodium Tablets 300 mcg to Synthroid® Tablets 300 mcg

NCT00648882
View directory record Official record
Conditions
Healthy
Interventions
LEVOTHYROXINE SODIUM TABLETS,, SYNTHROID® 300 mcg Tablets
Drug
Lead sponsor
Mylan Pharmaceuticals Inc
Industry
Eligibility
18 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 2, 2026, 5:17 AM EDT
Terminated Not applicable Interventional Results available

Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors

NCT00488644
View directory record Official record
Conditions
Hypothyroidism, Brain Tumor
Interventions
Levothyroxine, Liothyronine
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy

NCT03115515
View directory record Official record
Conditions
Pregnancy Related, Thyroid
Interventions
levothyroxine
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 2, 2026, 5:17 AM EDT
Recruiting Not applicable Interventional

A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients

NCT03977207
View directory record Official record
Conditions
Thyroid; Functional Disturbance, Hypothyroidism, Hemodialysis
Interventions
Levothyroxine Sodium, Placebos
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 2 Interventional Results available

Energy Metabolism in Thyroidectomized Patients

NCT04782856
View directory record Official record
Conditions
Thyroid Goiter, Hypothyroidism, Thyroid Cancer
Interventions
Levothyroxine, Liothyronine, Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 14, 2024 · Synced Oct 2, 2026, 5:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism

NCT02317926
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine, Levothyroxine Plus Liothyronine, Desiccated Thyroid Extract
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2015
U.S. locations
1
States / cities
Besthesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 6, 2015 · Synced Oct 2, 2026, 5:17 AM EDT
Completed Phase 1 Interventional

Study of T3 on the Incidence of Atrial Fibrillation in Patients Undergoing Cardiac Surgery

NCT00289367
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
triiodothyronine
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 85 Years
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2008 · Synced Oct 2, 2026, 5:17 AM EDT
Active, not recruiting Phase 2 Interventional

Treatment of ARDS With Instilled T3

NCT04115514
View directory record Official record
Conditions
ARDS, Human, Lung, Wet, Thyroid, Pulmonary Edema, Lung Inflammation
Interventions
Liothyronine Sodium (T3+0.9% sodium chloride) modified formulation specifically for airway instillation., Non-intervention
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Edina, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 2, 2026, 5:17 AM EDT