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ClinicalTrials.gov public records Last synced Oct 19, 2026, 5:10 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 52 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Large Language Model Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Physician Reasoning on Diagnostic Cases With Large Language Models

NCT06157944
View directory record Official record
Conditions
Diagnosis
Interventions
GPT-4
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 19, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional

Large Language Models To Improve the Quality of Care of Cardiology Patients

NCT06935253
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy (HCM), Cardiomyopathy, Genetic Disease, Cardiology
Interventions
Large Language Model
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Using AI to Improve Sepsis Quality of Care in the Emergency Department

NCT07581340
View directory record Official record
Conditions
Sepsis
Interventions
Near-real time automated feedback on SEP-1 performance
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Planetary Health and Environmental Justice in Construction Career Education

NCT07315919
View directory record Official record
Conditions
Health Knowledge, Environmental Exposure, Attitude, Practice
Interventions
Community-Centered Design Curriculum with EJT, Traditional Technical Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Not yet recruiting Not applicable Interventional

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

NCT07214831
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Large language model-based chatbot brief alcohol intervention session
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional

Generative AI Patient Education Module for Breast Oncology

NCT07512271
View directory record Official record
Conditions
Breast Cancer, Metastatic Breast Cancer, Carcinoma of the Breast
Interventions
Survey (Participant), OpenEvidence CareConnect, Survey (Provider)
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ambient AI for Reducing Nursing Staff Documentation Time

NCT07456241
View directory record Official record
Conditions
Nursing Documentation Burden
Interventions
Artificial Intelligence
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Active, not recruiting Not applicable Interventional

Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care

NCT07022769
View directory record Official record
Conditions
Any Chronic, Non-traumatic Orthopedic Condition
Interventions
LLM-facilitated cognitive debiasing aid
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial

NCT07107152
View directory record Official record
Conditions
Colorectal Cancer Control and Prevention
Interventions
single GPT generated message, AI Chatbot, Expert-Written Patient Materials
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 75 Years
Enrollment
915 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional

A Megastudy of Single-Session Interventions for Depression

NCT06856668
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Behavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation, Mindful Attention Skills, 5 Habits to Beat Depression, Interactive Cognitive Reappraisal, Expressive Writing (AI-supported), Inner Child Healing Walk, Savoring Strategies, Personalized Intervention Recommender, Dialectical Behavioral Therapy Skills, All about Trout, Reframing Negative Thoughts
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
7,505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Results available

A Randomized Controlled Trial of Ambient Artificial Intelligence Scribe Technologies

NCT06792890
View directory record Official record
Conditions
Physician Workflow, Artificial Intelligence (AI)
Interventions
Use Nabla AI Scribe tool provided, Use AI Scribe tool provided by Vendor B
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Not listed
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional

RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach

NCT06999226
View directory record Official record
Conditions
Scleroderma
Interventions
RENEW-AI
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diagnostic Reasoning With Customized GPT-4 Model

NCT06911645
View directory record Official record
Conditions
Pathologic Processes, Disease
Interventions
Immediate access to customized version of GPT-4, Access to customized version of GPT-4 following use of conventional resources
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support

NCT07037940
View directory record Official record
Conditions
Large Language Models
Interventions
OpenEvidence, GPT-4
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
25 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
2
States / cities
Boston, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Not yet recruiting Not applicable Interventional

Listen Aphasia Pilot Study

NCT07732140
View directory record Official record
Conditions
Aphasia, Malignant Brain Tumor
Interventions
LISTEN (AI-based AAC smartphone app)
Device
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Ambient AI Clinical Trial

NCT07598721
View directory record Official record
Conditions
Artificial Intelligence (AI), Physician Burnout, Physician Work Environment
Interventions
Use of Ambient AI scribe tool on participant's mobile device
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance

NCT05816473
View directory record Official record
Conditions
Gastrointestinal Hemorrhage
Interventions
LLM
Other
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial

NCT07293078
View directory record Official record
Conditions
Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure, Acute Kidney Injury, Delirium Confusional State, Shock
Interventions
Point-of-care large language model decision support (ChatGPT-5)
Other
Lead sponsor
MetroWest Artificial Intelligence Research Workgroup
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physician Reasoning on Management Cases With Large Language Models

NCT06208423
View directory record Official record
Conditions
Clinical Decision-making
Interventions
GPT-4
Other
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 19, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Digital Tools to Support Healthcare Decision Making

NCT07485725
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Project 3, Phase 2: Clinical Trial
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
3
States / cities
Tallahassee, Florida • Champaign, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of a Large Language Model-Based Educational Tool on Visual Field Test Reliability in Glaucoma Patients

NCT07327242
View directory record Official record
Conditions
Glaucoma, Eye Disorders, Visual Fields, Visual Field Tests
Interventions
LLM-based Education
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Language Evaluation With AI for Residents

NCT07222644
View directory record Official record
Conditions
Patient Communication
Interventions
educational LLM-based feedback tool
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 19, 2026, 5:10 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice

NCT07199231
View directory record Official record
Conditions
AI (Artificial Intelligence), Large Language Model, Generative Artificial Intelligence
Interventions
AI clinical reference tool
Other
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 19, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

DHL Survey on Generative AI for MyChart Messaging

NCT06108037
View directory record Official record
Conditions
Communication
Interventions
Generative AI for electronic communication and disclosure
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,454 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2023 · Synced Oct 19, 2026, 5:10 AM EDT