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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:46 PM EST

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Showing 145–168 of 1,020 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Laser therapy Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of a 2,910 nm Fractional Ablative Fiber Laser (UltraClear®) for Improvements of Skin Laxity and Lifting of the Lower Face, Submental, and Neck Treatment Areas

NCT07759817
View directory record Official record
Conditions
Skin Laxity (Submental and Neck), Skin Lifting and Tightening
Interventions
2910 nm fiber laser (UltraClear®)
Device
Lead sponsor
FA Corporation
Industry
Eligibility
35 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Prospect, Kentucky • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Nov 15, 2026, 5:46 PM EST
Completed No phase listed Observational

Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients

NCT04128878
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Sotalol, Dofetilide
Drug
Lead sponsor
Samir Saba
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Timeline
2019 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Results available

Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study

NCT03100435
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Er:YAG Laser, Carbon Fiber Curette
Device · Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Nov 15, 2026, 5:46 PM EST
Withdrawn Not applicable Interventional Accepts healthy volunteers

Subject Evaluation of a 1064nm Diode Laser/RF

NCT04090853
View directory record Official record
Conditions
Subcutaneous Fat Disorder
Interventions
Venus Bliss
Device
Lead sponsor
Venus Concept
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Denver, Colorado • Foxborough, Massachusetts • Woodmere, New York
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma

NCT01956942
View directory record Official record
Conditions
Open Angle Glaucoma
Interventions
Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
Device
Lead sponsor
David Belyea
Other
Eligibility
Not listed
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Nov 15, 2026, 5:46 PM EST
Recruiting Not applicable Interventional

Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery

NCT06282770
View directory record Official record
Conditions
Spinal Fusion, Chronic Lower Back Pain
Interventions
Laser Diode Brace, Sham Laser Diode Brace
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Nov 15, 2026, 5:46 PM EST
Completed Phase 1 Interventional

Identification and Treatment of Feeder Vessels in Macular Degeneration

NCT00018070
View directory record Official record
Conditions
Macular Degeneration
Interventions
Angiography, Laser Treatment
Procedure
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Results available

Tripeptide/Hexapeptide Topical and Hybrid Laser Treatment for Acne Scarring

NCT04606134
View directory record Official record
Conditions
Acne Scars - Mixed Atrophic and Hypertrophic
Interventions
Hybrid fractional laser, Alastin Regenerating Skin Nectar with TriHex Technology, Cetaphil face cream
Device · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Nov 15, 2026, 5:46 PM EST
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser

NCT03454672
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel, Laser
Device
Lead sponsor
Novoxel Ltd.
Industry
Eligibility
40 Years to 70 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Nov 15, 2026, 5:46 PM EST
Completed No phase listed Observational

Laser Speckle Imaging for Wound Perfusion Monitoring (WoundImager)

NCT01675583
View directory record Official record
Conditions
Wounds and Injuries
Interventions
Not listed
Lead sponsor
CW Optics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2013 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

A Prospective Evaluation of Contrast Sensitivity and Disability Glare in Refractive Surgery, a Sub-Study of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)

NCT00413868
View directory record Official record
Conditions
Myopia
Interventions
LASIK, PRK, Small target contrast sensitivity and disability glare
Procedure · Behavioral
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2008 · Synced Nov 15, 2026, 5:46 PM EST
Completed Phase 2 Interventional Results available

Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema

NCT02348918
View directory record Official record
Conditions
Diabetic Macular Edema
Interventions
Luminate 1.0mg, Luminate 2.0mg, Luminate 3.0mg, Avastin, Luminate 0.5mg
Drug
Lead sponsor
Allegro Ophthalmics, LLC
Industry
Eligibility
18 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
17
States / cities
Phoenix, Arizona • Beverly Hills, California • Mountain View, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2018 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI

NCT05493280
View directory record Official record
Conditions
Hyperpigmentation
Interventions
MOXI
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Results available

A Pilot Study Evaluating Photobiomodulation Therapy for Diabetic Macular Edema

NCT03866473
View directory record Official record
Conditions
Diabetic Macular Edema
Interventions
Retilux, Sham Light Device
Device
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
20
States / cities
Huntington Beach, California • Oakland, California • Santa Barbara, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2022 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Results available

Randomized Pilot Study of Treatment for BCC Using the Multiplex 595/1064 nm Laser

NCT02270645
View directory record Official record
Conditions
Nodular Basal Cell Carcinoma, Superficial Basal Cell Carcinoma
Interventions
595/1064 multiplex laser
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Nov 15, 2026, 5:46 PM EST
Completed Phase 1 Interventional

1320 nm Nd:YAG Laser for Improving the Appearance of Onychomycosis

NCT01498393
View directory record Official record
Conditions
Fungal Nail Infection
Interventions
Laser treatment
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Nov 15, 2026, 5:46 PM EST
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Laser Treatment for Fresh Surgical Scars and Mature Scars

NCT01030198
View directory record Official record
Conditions
New Surgical Scars, Scars
Interventions
RevLite (Laser Treatment)
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Nov 15, 2026, 5:46 PM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy Evaluation of the Mosaic Ultra Device

NCT06117293
View directory record Official record
Conditions
Skin Texture Disorder, Photoaging, Wrinkle, Scar, Stretch Mark, Acne Vulgaris, Hair Loss
Interventions
Mosaic
Device
Lead sponsor
CynosureLutronic
Industry
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
3
States / cities
Lincolnshire, Illinois • Billerica, Massachusetts • Peabody, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Nov 15, 2026, 5:46 PM EST
Not listed Phase 4 Interventional Accepts healthy volunteers

Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial)

NCT02092532
View directory record Official record
Conditions
Neovascular Polypoidal Choroidal Vasculopathy
Interventions
Rescue Intravitreal Aflibercept Injection, Rescue Therapy with PDT, Laser or Intravitreal Steroids
Drug · Procedure
Lead sponsor
Southeast Retina Center, Georgia
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 15, 2014 · Synced Nov 15, 2026, 5:46 PM EST
Active, not recruiting Not applicable Interventional

Pelvic Floor Physical Therapy to Reduce Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

NCT06209307
View directory record Official record
Conditions
Prostatic Hyperplasia, Stress Urinary Incontinence
Interventions
Pelvic floor physical therapy
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Male only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Nov 15, 2026, 5:46 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of PiQo4 Device for Treatment of Melasma

NCT03565341
View directory record Official record
Conditions
Melasma
Interventions
PiQo4
Device
Lead sponsor
Focus Medical, LLC
Industry
Eligibility
18 Years to 75 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 27, 2019 · Synced Nov 15, 2026, 5:46 PM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Clinical Study of the CO2RE Laser Device Performance for Vaginal Atrophy Treatments

NCT02704741
View directory record Official record
Conditions
Vaginal Atrophy
Interventions
CO2RE
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
35 Years and older · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
4
States / cities
Jacksonville, Florida • Louisville, Kentucky • Wayland, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Nov 15, 2026, 5:46 PM EST
Suspended Not applicable Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser.

NCT04103164
View directory record Official record
Conditions
Port-Wine Stain
Interventions
Cutera excel V™ Laser
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Nov 15, 2026, 5:46 PM EST