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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Leg exercise Clear all
Completed Not applicable Interventional

Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)

NCT01521728
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
Resistance Exercise, Endurance Exercise, Stretching/Range-of-Motion
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Los Angeles, California • Baltimore, Maryland • Charlestown, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy

NCT04799171
View directory record Official record
Conditions
Physical Activity
Interventions
Isometric Contraction Exercise - Young Adults (Age group 18-39), Isometric Contraction Exercise - Middle Age Adults (Age group 40-59), Isometric Contraction Exercise - Old Adults (Age group >60)
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Type 2 Diabetes and Exercise Function in Single Leg Exercises

NCT01793909
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Single Leg Exercise Training
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
30 Years to 70 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Training Improves Balance Control

NCT01547988
View directory record Official record
Conditions
Accidental Falls
Interventions
Balance Training Intervention
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
65 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Results available

Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover

NCT01245283
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
normal activities and clinical care, Concentric Focused Resistance Exercise, Eccentric Focused Resistance Exercise
Other
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2014 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Prevention of Osteoporosis in Breast Cancer Survivors

NCT00567606
View directory record Official record
Conditions
Postmenopausal Osteoporosis
Interventions
Strength/Weight Training & Drug/Supplement, Drug/Supplement only
Other · Combination Product
Lead sponsor
University of Nebraska
Other
Eligibility
35 Years to 75 Years · Female only
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
4
States / cities
Kearney, Nebraska • Lincoln, Nebraska • Omaha, Nebraska + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Sensorimotor Rehabilitation Program in Improving Quality of Life in Patients With Early Stage Breast Cancer

NCT03568526
View directory record Official record
Conditions
Peripheral Neuropathy, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7
Interventions
Educational Intervention, Exercise Intervention, Quality-of-Life Assessment, Questionnaire Administration, Survey Administration
Other · Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Knee Arthroplasty Rehabilitation Outcomes Study

NCT02426190
View directory record Official record
Conditions
Total Knee Arthroplasty, Rehabilitation
Interventions
Anti-gravity treadmill, PENS - neuro-muscular stimulation, Anti-gravity treadmill & PENS - neuro-muscular stimulation, Recumbent or Nu-step bike
Other
Lead sponsor
MedStar National Rehabilitation Network
Other
Eligibility
40 Years and older
Enrollment
386 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 6, 2026, 1:25 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Eccentric Potentiation Activation on Muscle Function

NCT05606276
View directory record Official record
Conditions
Post Activation Potentiation
Interventions
Eccentric Exercise, Cycle ergometer
Other
Lead sponsor
Brennan Thompson
Other
Eligibility
18 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Sep 6, 2026, 1:25 AM EDT
Recruiting Not applicable Interventional

Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

NCT05526417
View directory record Official record
Conditions
Soft Tissue Sarcoma, Stage I Soft Tissue Sarcoma of the Trunk and Extremities, Stage II Soft Tissue Sarcoma of the Trunk and Extremities, Stage III Soft Tissue Sarcoma of the Trunk and Extremities
Interventions
Computed Tomography, Educational Intervention, Magnetic Resonance Imaging, Physical Therapy, Questionnaire Administration, Telemedicine
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Not listed Not applicable Interventional

Exercise Targeting Cognitive Impairment in Parkinson's Disease

NCT02267785
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Skill-Based Exercise, Aerobic Exercise, Social Contact
Other
Lead sponsor
University of Southern California
Other
Eligibility
30 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Heat Therapy, Functional Capacity, and Vascular Health in Older Adults

NCT05706181
View directory record Official record
Conditions
Aging Well, Walking, Difficulty, Hyperemia
Interventions
Home-based leg heat therapy, Home-based sham therapy
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
55 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Results available

The Effect of Exercise on Individuals With Parkinson's Disease

NCT00591344
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Progressive resistance training, Modified Fitness Counts
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
50 Years to 67 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 4, 2015 · Synced Sep 6, 2026, 1:25 AM EDT
Active, not recruiting Not applicable Interventional

Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users

NCT03930199
View directory record Official record
Conditions
Amputation
Interventions
Needs-based intervention (physical, psychological, or both)
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 89 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
3
States / cities
Chicago, Illinois • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Does Style of Pre-sedation Instructions Improve Patient Outcomes in Ambulatory Anesthesia for Oral and Maxillofacial Surgery?

NCT06768021
View directory record Official record
Conditions
Anesthesia Outcomes, Anesthesia Complication, Anesthesia and Procedure Related Time Intervals, Anesthesia Recovery Period, Anesthesia, Intravenous, Anesthesia Induction
Interventions
Guided visualization and standardized pre-sedation instructions, Standardized pre-sedation instructions only
Behavioral
Lead sponsor
Alameda Health System
Other
Eligibility
8 Years to 70 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A System for Lengthening Contraction Training of Muscle

NCT00575107
View directory record Official record
Conditions
Healthy
Interventions
Exercise
Other
Lead sponsor
University of Michigan
Other
Eligibility
65 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 3, 2011 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Aerobic and Strengthening Exercise for Acute Leukemia

NCT00766311
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia
Interventions
Gross Motor Function, Knee extension strength, Hand grip strength, Flexibility, Ankle range of motion, Aerobic capacity, Body composition and vital signs
Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
5 Years to 10 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Portland, Oregon • Philadelphia, Pennsylvania • Memphis, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2012 · Synced Sep 6, 2026, 1:25 AM EDT
Not listed Not applicable Interventional

Comparison of Craniosacral Therapy vs Pelvic Floor Physical Therapy

NCT03213522
View directory record Official record
Conditions
Multiple Sclerosis, Bladder Dysfunction, Urinary Incontinence, Overactive Bladder
Interventions
Pelvic Floor Physical Therapy, Craniosacral Therapy
Procedure
Lead sponsor
CentraState Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Freehold, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Results available

Physical Activity Interventions To Heal Chronic Low Back Pain

NCT04678297
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Physical activity + emotion regulation intervention, Physical activity control intervention
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Storrs Mansfield, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Results available

Reversing Diabetic Peripheral Neuropathy Through Exercise

NCT03686423
View directory record Official record
Conditions
Peripheral Neuropathy, Diabetes
Interventions
Exercise Program
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
40 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Sep 6, 2026, 1:25 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Influences of Blood Flow Restriction on Leg Press

NCT07052227
View directory record Official record
Conditions
Delfi Cuff, Fitcuff, Placebo - Control
Interventions
Delfi blood flow restriction cuff, Fitcuffs, Control
Device · Other
Lead sponsor
Salisbury University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Sep 6, 2026, 1:25 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Immediate and 24-hour Effects of HyperVolt, Body Tempering, and Cupping Compared to Stretching on Hamstring Flexibility

NCT05793242
View directory record Official record
Conditions
Hamstring Contractures, Muscle Tightness
Interventions
Hypervolt, Body Tempering, Dry cupping, Static stretching
Device · Other
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 39 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional Results available

Effect of Mirror Therapy on Lower Extremity Motor Control and Gait in Patients With Stroke

NCT01574079
View directory record Official record
Conditions
Stroke
Interventions
Traditional Physical Therapy, Physical Therapy plus Mirror Therapy
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Sep 6, 2026, 1:25 AM EDT
Completed Not applicable Interventional

To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength

NCT01080703
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Exercise
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Sep 6, 2026, 1:25 AM EDT