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ClinicalTrials.gov public records Last synced Oct 24, 2026, 6:41 AM EDT

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Showing 409–432 of 1,003 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Local Anesthesia Clear all
Completed No phase listed Observational

Exploring the Efficacy of Assistive Artificial Intelligence for Ultrasound Guided Regional Anesthesia in Residency Training

NCT06667401
View directory record Official record
Conditions
Regional Anesthesia
Interventions
The ScanNav, a novel artificial intelligence device designed to assist in Ultrasound guided regional anesthesia
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
20 participants
Timeline
2025 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Recruiting Early Phase 1 Interventional

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

NCT05461092
View directory record Official record
Conditions
Delirium, Pain, Back, Spinal Fusion, Thoracolumbar Interfascial Plane Block
Interventions
Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Blood Test, 3D CAM Delirium Severity Scoring, Generalized Anxiety Disorder 7-item (GAD-7) scale, Numerical Rating Score (NRS), PROMIS-Pain Interference, Oswestry Disability Index (ODI), Saint Louis University Mental Status Examination (SLUMs), Delirium Rating Scale-Revised-98 (DRS), Telephone Interview for Cognitive Status - Modified (TICS-M), Opioid Equivalents measured by Morphine Milligram Equivalents (MME), Patient Health Questionnaire depression scale (PHQ-8), Pain Catastrophizing, Fear Avoidance Beliefs Questionnaire (FABQ), Opioid Side Effects and Likeability Questionnaire, Daily Pain Trajectory, Tampa Scale of Kinesiophobia, Quality of Recovery 15
Drug · Diagnostic Test · Other
Lead sponsor
University of Iowa
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional Results available

Addition of Pudendal Blocks to Pelvic Floor Physical Therapy for the Treatment of Pelvic Floor Tension Myalgia

NCT00928564
View directory record Official record
Conditions
Pelvic Floor Muscle Spasm
Interventions
Pudendal block, Placebo
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional

Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT07052721
View directory record Official record
Conditions
Rotator Cuff Tears, Shoulder Injuries, Hallux Valgus, Ankle Arthropathy, Clavicle Fracture
Interventions
Experimental Treatment, Sham Comparator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional

Treatment of Chronic Low Back and Lower Extremity Pain

NCT00681447
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Interlaminar Epidural, Lumbar Interlaminar Epidural injection
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 21, 2015 · Synced Oct 24, 2026, 6:41 AM EDT
Terminated Phase 3 Interventional Results available

A Prospective Controlled Treatment Trial for Post-Traumatic Headaches

NCT03007420
View directory record Official record
Conditions
Post-Traumatic Headaches
Interventions
Occipital Nerve Block (ONB) using lidocaine and dexamethosone, Cervical Medial Branch Block (CMBB) using lidocaine and dexamethosone
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 6:41 AM EDT
Terminated Phase 4 Interventional Results available

Avoiding Neuromuscular Blockers to Reduce Complications

NCT03962725
View directory record Official record
Conditions
Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis, Atelectasis, Bronchospasm
Interventions
Neuromuscular Blocking Agents, Anesthetic Adjuncts
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Early Phase 1 Interventional

Pterygopalatine Fossa Block in Aneurysmal Subarachnoid Hemorrhage

NCT05925478
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
Ptergyopalatine Fossa Block, Bupivacaine 0.25% Injectable Solution
Procedure · Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 4 Interventional

The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache

NCT00574015
View directory record Official record
Conditions
Toothache
Interventions
hydrocodone/acetaminophen, bupivacaine (supraperiosteal nerve block)
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2014 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional

Abdominal Wall Block Study

NCT03074240
View directory record Official record
Conditions
Umbilical Hernia, Obesity
Interventions
TAPB Group, RSB Group, conversion to general anesthesia
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 2 Interventional

Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea

NCT00503802
View directory record Official record
Conditions
Sleep Apnea Syndromes, Nasal Obstruction, Turbinate Hypertrophy
Interventions
Radiofrequency Turbinate Reduction, Sham RF
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 19, 2013 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 4 Interventional Results available

Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine

NCT01709708
View directory record Official record
Conditions
Chronic Migraine
Interventions
Marcaine, Saline
Drug
Lead sponsor
Tian Medical Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Ann Arbor, Michigan • Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2018 · Synced Oct 24, 2026, 6:41 AM EDT
Recruiting Phase 2Phase 3 Interventional

Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

NCT05766891
View directory record Official record
Conditions
Breast Cancer
Interventions
Group 1, Group 2, Group 3
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 24, 2026, 6:41 AM EDT
Completed No phase listed Observational

Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain

NCT04057989
View directory record Official record
Conditions
Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder, Trauma, Brain
Interventions
ketamine
Drug
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter

NCT00686231
View directory record Official record
Conditions
Healthy
Interventions
Nitroglycerin 15mg, Nitroglycerin 30mg, Lidocaine 20mg, Lidocaine 40mg, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 4 Interventional Results available

Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain

NCT00443781
View directory record Official record
Conditions
Low Back Pain
Interventions
functional anesthetic discography, provocative discography
Procedure
Lead sponsor
Medtronic Spine LLC
Industry
Eligibility
21 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
10
States / cities
Huntsville, Alabama • Beverly Hills, California • Escondido, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Oct 24, 2026, 6:41 AM EDT
Withdrawn Not applicable Interventional

Pain Management in Children Undergoing Supracondylar Humerus Fracture Repair

NCT01812863
View directory record Official record
Conditions
Humeral Fractures, Fractures, Closed
Interventions
Supraclavicular nerve block
Procedure
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
2 Years to 10 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair

NCT01500109
View directory record Official record
Conditions
Cleft Palate
Interventions
Oral acetaminophen, Ofirmev®, Opioid only
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
5 Months to 5 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Effectiveness of Bilateral ESPB in Addition to Standard Analgesia at Reducing Opioid Consumption

NCT03954249
View directory record Official record
Conditions
Anesthesia, Block
Interventions
Erecto Spinae nerve block, Multimodal Analgesia
Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Recruiting Phase 2 Interventional

Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

NCT07061847
View directory record Official record
Conditions
Migraine
Interventions
Lidocaine (drug), Lidocaine Procedure
Drug · Procedure
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Not applicable Interventional

Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy

NCT06309693
View directory record Official record
Conditions
Pelvic Organ Prolapse, Post Operative Pain
Interventions
Quadratus Lumborum (QL) Block, Enhanced Recovery After Surgical (ERAS) Protocol
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

New Topical Treatment for Continued Pain After Shingles

NCT00566904
View directory record Official record
Conditions
Postherpetic Neuralgia
Interventions
Epikeia coatings with aspirin, Epikeia coatings with lidocaine, Epikeia coatings alone
Drug · Other
Lead sponsor
Biomedical Development Corporation
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 31, 2011 · Synced Oct 24, 2026, 6:41 AM EDT
Completed Phase 3 Interventional Results available

A Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2 - Protocol B

NCT03319849
View directory record Official record
Conditions
Macular Telangiectasia Type 2
Interventions
NT-501, Sham
Combination Product · Procedure
Lead sponsor
Neurotech Pharmaceuticals
Industry
Eligibility
21 Years to 80 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
22
States / cities
Beverly Hills, California • Colorado Springs, Colorado • Atlanta, Georgia + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Oct 24, 2026, 6:41 AM EDT