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ClinicalTrials.gov public records Last synced Oct 28, 2026, 2:32 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1417–1440 of 1,505 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Local ablative therapy Clear all
Recruiting Not applicable Interventional

A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System

NCT07227532
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulsed Field Ablation by VARIPULSE Catheter with TRUPULSE Generator
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
22 Years and older
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
23
States / cities
Phoenix, Arizona • Tucson, Arizona • Fountain Valley, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Terminated Phase 2 Interventional Results available

A Phase II Study of Umbilical Cord Blood Transplantation

NCT00676806
View directory record Official record
Conditions
Leukemia, Lymphoma, Multiple Myeloma, Aplastic Anemia
Interventions
Umbilical Cord Blood After Myeloablative Conditioning, Umbilical Cord Blood After Reduced-Intensity Conditioning
Biological
Lead sponsor
Tufts Medical Center
Other
Eligibility
Up to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)

NCT03867084
View directory record Official record
Conditions
Hepatocellular Carcinoma
Interventions
Pembrolizumab, Placebo
Biological · Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
18 Years and older
Enrollment
959 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
24
States / cities
Gilbert, Arizona • Tucson, Arizona • Duarte, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Completed No phase listed Observational

Outcome of Patients With Lung Masses Who Are Treated With Radiofrequency Ablation (RFA)

NCT00641238
View directory record Official record
Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
Radiofrequency ablation
Device
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 28, 2026, 2:32 AM EDT
Completed No phase listed Observational

Parallel Mapping for Ventricular Tachycardia

NCT04477499
View directory record Official record
Conditions
Ventricular Tachycardia (V-Tach), Implantable Cardioverter Defibrillator (ICD), Arrythmia
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Oct 28, 2026, 2:32 AM EDT
Not listed Not applicable Interventional

Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.

NCT00591552
View directory record Official record
Conditions
Lung Cancer
Interventions
Harmonic ACE23P Scalpel, Electrocautery
Device
Lead sponsor
Sentara Cardiovascular Research Institute
Other
Eligibility
20 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2024
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 28, 2026, 2:32 AM EDT
Not yet recruiting Not applicable Interventional

Comparison of Holmium Laser Enucleation of the Prostate and Robotic Water Jet Ablation for Benign Prostatic Hyperplasia

NCT07772232
View directory record Official record
Conditions
Benign Prostate Hypertrophy(BPH), Lower Urinary Track Symptoms
Interventions
Device - HoLEP with MOSES 2.0, RWJA with Hydros Robotic System
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
50 Years to 80 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Suspended Phase 2 Interventional

Radiofrequency Ablation (RFA) Of Tumors Acquired In Childhood

NCT00868647
View directory record Official record
Conditions
Neoplasms, Benign, Neoplasms, Malignant
Interventions
Radiofrequency ablation (RFA)
Procedure
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 1, 2009 · Synced Oct 28, 2026, 2:32 AM EDT
Recruiting No phase listed Observational

A Prospective Cohort Study of Basivertebral Nerve Ablation Using the Stryker OptaBlate BVN System for the Treatment of Vertebrogenic Low Back Pain

NCT07392333
View directory record Official record
Conditions
Verteborgenic Low Back Pain, Back Pain Lower Back
Interventions
Basivertebral nerve ablation
Device
Lead sponsor
Stryker Instruments
Industry
Eligibility
22 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Not applicable Interventional Results available

TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation

NCT03354663
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
TactiCath SE
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
14
States / cities
Little Rock, Arkansas • La Jolla, California • Redwood City, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Oct 28, 2026, 2:32 AM EDT
Completed No phase listed Observational

Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation

NCT04006184
View directory record Official record
Conditions
Varicose Veins, Venous Reflux, Venous Insufficiency
Interventions
Chart review
Other
Lead sponsor
Lake Washington Vascular
Other
Eligibility
18 Years and older
Enrollment
547 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Oct 3, 2019 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 1Phase 2 Interventional Results available

MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas

NCT02311582
View directory record Official record
Conditions
Malignant Glioma
Interventions
MK-3475, MRI-guided laser ablation
Biological · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
2
States / cities
Gainesville, Florida • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 28, 2026, 2:32 AM EDT
Completed No phase listed Observational Results available

CLBP Single-Arm Long-Term Follow-up Study

NCT05207813
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Intracept Procedure
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
25 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Carmel, Indiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 28, 2026, 2:32 AM EDT
Not listed Phase 1 Interventional

Open-label Multicenter Phase 1 Study of TBI 302 as Second-Line Therapy in Patients With Hepatocellular Carcinoma

NCT03908840
View directory record Official record
Conditions
Hepatocellular Carcinoma
Interventions
TBI 302
Biological
Lead sponsor
Evolve Biologics
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Oct 28, 2026, 2:32 AM EDT
Not yet recruiting Not applicable Interventional

A Study to Predict Atrial Fibrillation (AF) Burden in Participants With PAF and PsAF Treated With the VARIPULSE™ PFA Catheter

NCT07788989
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
VARIPULSE Catheter System (PVI), VARIPULSE Catheter System (PVI and PWI)
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
2,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Results available

Use of Dapagliflozin to Reduce Burden of Atrial Fibrillation in Patients Undergoing Catheter Ablation of Symptomatic Atrial Fibrillation

NCT04792190
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
dapagliflozin, Placebo
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Portland, Maine • Detroit, Michigan • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Oct 28, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional

LASIK Using Contoura With Phorcides vs. iDesign

NCT07128316
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Contoura Topolyzer with Phorcides, iDesign
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
21 Years to 50 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Cooled Radiofrequency Ablation vs. Thermal Radiofrequency Ablation

NCT02073292
View directory record Official record
Conditions
Chronic Thoracic Back Pain
Interventions
c-RFA, tRFA
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 1Phase 2 Interventional

Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

NCT00003619
View directory record Official record
Conditions
Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Thrombocytopenia
Interventions
filgrastim, vitamin E, busulfan, cytarabine, etoposide, fludarabine phosphate, isotretinoin, topotecan hydrochloride, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation
Biological · Dietary Supplement · Drug + 1 more
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
19 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 26, 2013 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 1 Interventional

Photodynamic Therapy Using HPPH in Treating Patients With Dysplasia, Cancer in Situ, or Invasive Cancer of the Larynx

NCT00675233
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
HPPH, laser therapy
Drug · Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Oct 28, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Results available

Impact of Renal SympAthetic DenerVation on Chronic HypErtension

NCT01628198
View directory record Official record
Conditions
Uncontrolled Hypertension
Interventions
Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter
Device
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 19, 2018 · Synced Oct 28, 2026, 2:32 AM EDT
Recruiting No phase listed Observational

Standardized Prenatal Clinical Care for LUTO

NCT02315521
View directory record Official record
Conditions
Urethral Obstruction
Interventions
Fetal Intervention for LUTO
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
11 Weeks to 2 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 28, 2026, 2:32 AM EDT
Not listed Not applicable Interventional

Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2018 · Synced Oct 28, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer

NCT00182793
View directory record Official record
Conditions
Breast Cancer
Interventions
trastuzumab, carboplatin, cyclophosphamide, melphalan, thiotepa, adjuvant therapy, autologous-autologous tandem hematopoietic stem cell transplantation, bone marrow ablation with stem cell support, radiation therapy
Biological · Drug · Procedure + 1 more
Lead sponsor
City of Hope Medical Center
Other
Eligibility
Up to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 28, 2026, 2:32 AM EDT