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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Loneliness Intervention Clear all
Not listed No phase listed Observational

Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD)

NCT04455646
View directory record Official record
Conditions
Data Collection for Facilitation of Machine Learning Algorithm for Personalized Treatment
Interventions
CBT-based, mobile-delivered, intervention platform
Behavioral
Lead sponsor
Brainsway
Industry
Eligibility
22 Years to 68 Years
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
22
States / cities
San Diego, California • Juno Beach, Florida • Palm Beach, Florida + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Reduce Loneliness in Care Partners of Persons With AD/ADRD

NCT05460494
View directory record Official record
Conditions
Loneliness
Interventions
RELOAD-C
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Manhasset, New York • New Hyde Park, New York • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Results available

Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors

NCT06331403
View directory record Official record
Conditions
Colorectal Cancer, Anal Cancer, Sexual Dysfunction
Interventions
Mind-Body Group Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Recruiting Not applicable Interventional

Characterizing the Impact of Presbyphonia on Social Interaction

NCT06441136
View directory record Official record
Conditions
Presbyphonia
Interventions
PhoRTE Program, University of California Los Angeles (UCLA) Loneliness Scale, Social Disconnectedness Scale, Patient Health Questionnaire 9, Aging Voice Index, The Edmonton Frail Scale, Vocal Effort Scale, Montreal Cognitive Assessment, Voice Handicap Index-10, Voice Problem Impact Scales, Cough Severity Index, Laryngoscopy, Acoustic, perceptual, and aerodynamic assessments
Other · Procedure
Lead sponsor
Matthew R. Hoffman
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ADHOC Mindfulness-Based Research

NCT04580082
View directory record Official record
Conditions
Hiv, Loneliness, Depression, Anxiety
Interventions
Mindfulness lessons
Behavioral
Lead sponsor
Mazonson & Santas Inc.
Industry
Eligibility
50 Years and older
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Larkspur, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 17, 2026, 12:13 AM EDT
Recruiting Not applicable Interventional

Bridge to Belonging: Peer Led Intervention to Reduce Loneliness and Depression Among Older Gay and Bisexual Men

NCT07762066
View directory record Official record
Conditions
HIV
Interventions
B2B Intervention, Control condition
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Connect ME: Improving Social Connectedness

NCT05686681
View directory record Official record
Conditions
Social Connectedness
Interventions
Brief Behavioral Activation for Improving Social Connectedness
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Heartfulness Self-Care Program on Anxiety, Satisfaction With Life, and Loneliness Levels in Students and Staff in High Schools.

NCT05874232
View directory record Official record
Conditions
Anxiety, Satisfaction With Life, Loneliness
Interventions
Self-Care Program through Heartfulness
Behavioral
Lead sponsor
Heartfulness Institute
Other
Eligibility
14 Years to 80 Years
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Sep 17, 2026, 12:13 AM EDT
Recruiting Not applicable Interventional

Increasing Veterans' Social Engagement and Connectedness

NCT06467214
View directory record Official record
Conditions
Social Isolation
Interventions
CONNECTED, VET BEFRIENDING
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Results available

SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning

NCT03034863
View directory record Official record
Conditions
Suicide
Interventions
Safe Actions for Families to Encourage Recovery, Individual Safety Planning Intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2021 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Results available

Suicide Safety Planning Group Treatment: "Project Life Force"

NCT02525575
View directory record Official record
Conditions
Suicide
Interventions
Project Life Force Group Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Alcohol Cessation Among Head and Neck Cancer Survivors

NCT05570851
View directory record Official record
Conditions
Head and Neck Cancer, Alcohol Use, Unspecified
Interventions
Alcohol Cessation Text Messages, Usual Care
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Recruiting Not applicable Interventional

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

NCT06969261
View directory record Official record
Conditions
Perinatal Opioid Use Disorder, Opioid Use Disorder
Interventions
Penny COPILOT
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Smartphone Intervention for Relational and Mental Well Being

NCT04629755
View directory record Official record
Conditions
Depression, Loneliness, Relation, Interpersonal, Covid19
Interventions
Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,765 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Heartfulness Program on Loneliness in High School Students in the US

NCT04602455
View directory record Official record
Conditions
Loneliness
Interventions
Self-Care Program through Heartfulness
Behavioral
Lead sponsor
Heartfulness Institute
Other
Eligibility
14 Years to 19 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2020 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Results available

Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults

NCT04966910
View directory record Official record
Conditions
Depression, Anxiety, Loneliness
Interventions
Stay Connected, Treatment as usual
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders

NCT03552328
View directory record Official record
Conditions
Aged, Loneliness, Depression, Anxiety
Interventions
Lunch with Medical Student, Control
Other
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2019 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Loneliness Epidemic Tailoring Interventions to Reduce Loneliness and Pain

NCT05387447
View directory record Official record
Conditions
Pain, Chronic, Loneliness
Interventions
Conversational Voice Assistant (Enhanced), Conversational Voice Assistant (Standard)
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
60 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
4
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Using Virtual Reality Travel to Reduce Loneliness in Older Adults

NCT07644416
View directory record Official record
Conditions
Loneliness, Older Adults (65 Years and Older), Virtual Reality, Leisure Activities
Interventions
Virtual Reality Travel, Puzzle-Based Attention Control Activity
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
3
States / cities
Bloomington, Indiana • Ellettsville, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Study 1: Social Engage Coaching R61 Phase

NCT05745493
View directory record Official record
Conditions
Social Isolation, Loneliness, Suicide Ideation, Quality of Life
Interventions
Social Engage Coaching (S-ENG)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Computerized Intervention for Interpersonal Stress

NCT04271111
View directory record Official record
Conditions
Hostility
Interventions
Online Treatment for Interpersonal Stress, Physical Health Education Tool
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 8, 2021 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury

NCT05295108
View directory record Official record
Conditions
Spinal Cord Injuries and Disorders (SCI/D)
Interventions
Caring Connections, Attention control
Other
Lead sponsor
Chicago Association for Research and Education in Science
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional

iWellness Study to Evaluate a Mental Health App for Students

NCT05234970
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Wysa, Harvard College App
Other
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Sep 17, 2026, 12:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Learning to PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia

NCT04649164
View directory record Official record
Conditions
Lewy Body Disease, Parkinson Disease Dementia, Dementia With Lewy Bodies
Interventions
Peer mentor support and caregiver intervention, Focus group to provide feedback on educational materials and mentoring program
Behavioral · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years to 90 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Sep 17, 2026, 12:13 AM EDT