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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low Flow Oxygen Clear all
Recruiting Not applicable Interventional

Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)

NCT05967507
View directory record Official record
Conditions
Airway Management
Interventions
Low-flow nasal supplemental oxygen with a conventional nasal cannula during tracheal intubation with the C-MAC video laryngoscope, High-flow nasal supplemental oxygen (Fisher & Paykel, Auckland, New Zealand) during tracheal intubation with the C-MAC video laryngoscope
Device
Lead sponsor
Thomas Riva
Other
Eligibility
Up to 52 Weeks
Enrollment
1,192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Not listed Not applicable Interventional

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

NCT02460653
View directory record Official record
Conditions
Respiratory Insufficiency, Hypoxia
Interventions
HFNC Flow Rate
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Weeks to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Sep 6, 2026, 2:26 AM EDT
Recruiting Phase 2 Interventional

Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

NCT06336642
View directory record Official record
Conditions
Dyspnea
Interventions
SPOT-ON Early Start, SPOT-ON Delayed Start
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Terminated Not applicable Interventional

Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT04217746
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
Interventions
High Flow Nasal Cannula
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome

NCT02587832
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
HHHFNC, NCPAP
Device
Lead sponsor
Sidra Medicine
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 26, 2015 · Synced Sep 6, 2026, 2:26 AM EDT
Withdrawn Not applicable Interventional

Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center

NCT05754255
View directory record Official record
Conditions
Colonoscopy, Positive-Pressure Respiration
Interventions
Nasal Cannula, Nasal Positive Airway Pressure System
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Physiological Changes With High-Flow Nasal Cannula

NCT03700606
View directory record Official record
Conditions
Respiratory Distress Syndrome in Premature Infant
Interventions
High flow nasal cannula, Nasal CPAP
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
23 Weeks to 28 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Osteopathic Manipulative Treatment and Bio Electro-Magnetic Regulation Therapy on Low Back Pain in Adults.

NCT04704375
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Bio Electro-Magnetic Regulation (BEMER) Therapy, OMT (osteopathic manipulative treatment), Light touch
Device · Procedure
Lead sponsor
Lake Erie College of Osteopathic Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Pain Biomarker Study

NCT03511846
View directory record Official record
Conditions
Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua, Paroxysmal Hemicrania, SUNCT, Short-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing
Interventions
Oral capsaicin, Topical capsaicin, Intranasal capsaicin, Cold Water Irrigation, Medical Air, Low Flow Oxygen, High Flow Oxygen
Drug · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Terminated Phase 3 Interventional Results available

The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea

NCT03745898
View directory record Official record
Conditions
Heart Failure, Central Sleep Apnea
Interventions
Oxygen, Room Air
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
26
States / cities
Tucson, Arizona • Stanford, California • New Haven, Connecticut + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Active, not recruiting Not applicable Interventional

The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial

NCT05523479
View directory record Official record
Conditions
Acute Respiratory Failure, Airway Extubation
Interventions
Traditional online education, Interprofessional education, Clinical protocol, Risk-stratified preventive post-extubation noninvasive ventilation (NIV) or high-flow nasal cannula oxygen (HFNC), Preventive post-extubation high-flow nasal cannula oxygen (HFNC)
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
13,018 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
17
States / cities
Carlisle, Pennsylvania • Hanover, Pennsylvania • Harrisburg, Pennsylvania + 7 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Not listed Phase 2 Interventional Results available

High-Flow Oxygen in Reducing Shortness of Breath Caused by Exercise in Patients With Cancer

NCT02357134
View directory record Official record
Conditions
Dyspnea, Malignant Neoplasm
Interventions
Oxygen Therapy, Quality-of-Life Assessment, Questionnaire Administration, Respiratory Therapy
Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 2 Interventional Results available

High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients

NCT02932332
View directory record Official record
Conditions
Cancer
Interventions
High-flow Oxygen, Low-flow Oxygen, High-flow Air, Low-flow Air
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants

NCT02858154
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
HFNC, Low flow oxygen by nasal cannula
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 12 Months
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Kansas City, Kansas • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19

NCT04426695
View directory record Official record
Conditions
COVID-19
Interventions
REGN10933+REGN10987 combination therapy, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
2,252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
96
States / cities
Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics

NCT04226131
View directory record Official record
Conditions
Rheumatoid Arthritis, Healthy Controls
Interventions
Blood Draw, Disease Activity (DAS-28) Assessment, Skeletal Muscle Mitochondrial Respiratory Capacity, Muscle Biopsy, Body Composition, Cardiopulmonary Exercise Test (CPET), Strength Testing, Questionnaires, Skeletal Muscle Biomechanical Property Assessment
Other
Lead sponsor
Duke University
Other
Eligibility
25 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

High-Flow Oxygen Therapy Following Tracheostomy

NCT03721419
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
High Flow High Humidity device, Low Flow High Humidity device
Device
Lead sponsor
Barnes-Jewish Hospital
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Sep 6, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional

Optimizing High Flow Nasal Cannula Oxygenation in Pediatric Airway Procedures

NCT06947902
View directory record Official record
Conditions
Airway Disorder
Interventions
High flow, Low Flow
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
0 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 6, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD

NCT06578156
View directory record Official record
Conditions
COPD
Interventions
Nasal High Flow Cannula, Nasal Low Flow Cannula
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Treating Sleep Apnea Induced Hypoxemia With Oxygen in Acute Stroke Patients

NCT03300063
View directory record Official record
Conditions
Stroke, Acute
Interventions
Low flow nocturnal oxygen
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Sep 6, 2026, 2:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation

NCT05091723
View directory record Official record
Conditions
Acute Lung Injury (ALI) Due to Coronavirus Disease-2019 (COVID-19)
Interventions
Nezulcitinib (TD-0903) Dose A, Nezulcitinib (TD-0903) Dose B
Drug
Lead sponsor
Theravance Biopharma
Industry
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2021 · Synced Sep 6, 2026, 2:26 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

High Flow Nasal Cannula Rates in Pediatric Asthma

NCT06379607
View directory record Official record
Conditions
Pediatric Asthma
Interventions
"High Flow" High Flow Nasal Cannula, "Low Flow" High Flow Nasal Cannula
Device
Lead sponsor
University of Rochester
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 6, 2026, 2:26 AM EDT
Recruiting Phase 2 Interventional

MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

NCT06930638
View directory record Official record
Conditions
Stroke
Interventions
Ischemic Conditioning, Antioxidant Supplement
Device · Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Sep 6, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain

NCT07367139
View directory record Official record
Conditions
Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
Interventions
Water
Other
Lead sponsor
Milwaukee VA Medical Center
Federal
Eligibility
20 Years to 45 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 6, 2026, 2:26 AM EDT