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ClinicalTrials.gov public records Last synced Nov 4, 2026, 11:22 PM EST

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Showing 25–48 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low level nicotine cigarette Clear all

Conditions: Smoking, Nicotine Addiction, Surgery
Interventions: ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years and older
Enrollment: 308 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Tobacco Use Disorder
Interventions: Cigarettes with varying nicotine content, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Cigarette Smoking
Interventions: High-ventilated cigarette alone, Low-ventilated cigarette alone, High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price, Low- and high-ventilated cigarette with high-ventilated cigarettes increasing in price, Usual, high- and low-ventilated cigarette with usual cigarettes increasing in price.; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Nicotine Dependence
Interventions: Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes; Behavioral · Drug
Lead sponsor: Rutgers University; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Tobacco Dependence
Interventions: Very low nicotine content cigarettes, standard nicotine content cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking ( Cigarette)
Interventions: Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose, Sugar syrup (Placebo); Drug · Dietary Supplement
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 59 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Bupropion and NRT; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 407 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence
Interventions: Nicotine, JUUL e-cigarette; Drug · Device
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Use, Cigarette Use
Interventions: Emotion-based messages about the harm of VLNC, Continued-harm-framed messages about the harm of VLNC, Myth-refuting messages about the harm of VLNC, Control messages about littering; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 1,153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Tobacco Dependence
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: Promotion factors, Mitigation strategies; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking Cessation
Interventions: Motivational Interviewing (MI), Nicotine Replacement Therapy (NRT), Nicotine Lozenge, Message Framing, saliva sample; Behavioral · Drug · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 50 Years to 80 Years
Enrollment: 807 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 18
States / cities: Los Angeles, California • Walnut Creek, California • La Grange, Georgia + 14 more

Conditions: Cigarette Smoking
Interventions: Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Buffalo, New York • Roanoke, Virginia

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Tobacco Use
Interventions: VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C); Other · Drug
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Tobacco Use
Interventions: SPECTRUM cigarettes, usual brand of Cigarettes; Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years and older
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
Interventions: Brief Intervention with NRT Initiation; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Advertisement content (explicit vs. implicit), Advertisement content (true vs. misleading); Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 29 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Coronary Artery Disease, Myocardial Perfusion
Interventions: Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid); Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 49 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking Cessation
Interventions: Questionnaire, In-Depth Interviews, Breath Test, Nicotine Patches, Advice plus Phone Counseling, Advice plus Counseling Sessions, Self Assessment Questionnaires; Behavioral · Other · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 25 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking, E-cigarette Use
Interventions: Nicotine Content, Illegal cigarette price, E-cigarette price; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Tobacco Use Disorder
Interventions: Varying the nicotine content of cigarettes, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 44 Years · Female only
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Nicotine Use Disorder
Interventions: E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1), E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2), E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2), E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2), E-liquid coolant (High [2.0%] WS-3) for non-menthol (3), E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3), E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3), E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4), E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4), E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4), E-liquid coolant (High [2.0%] WS-23) for non-menthol (5), E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5), E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5), E-liquid coolant (4% WS-23) for non-menthol (6), E-liquid coolant (4% WS-23) for low (0.1%) menthol (6), E-liquid coolant (4% WS-23) for high (2.0%) menthol (6); Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Search by objective public record fields.

The END Perioperative Smoking Pilot Study

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products

Evaluation of Learning-Theory-Based Smoking Cessation Strategies

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

Impact of Sweeteners on the Addictive Threshold of Nicotine

Maintaining Abstinence in Chronic Cigarette Smokers - 1

Do Flavors Increase the Addiction Potential of Nicotine?

Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

Promotion and Mitigation Factors Leading to Illegal Tobacco Purchases

Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites

The Impact of Innovative Tax Proposals on Purchase Patterns

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes

Cardiovascular Effects of Very Low Nicotine Content Cigarettes

Treating Low-Income Smokers in the Hospital Emergency Department

Young Adults' Reactions to Low Nicotine Cigarette Advertising

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

Health Literacy and Smoking Cessation in Low-SES Diverse Smokers - Project HALT II

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0